Kurt R Brunden

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Research Professor of Pathology and Laboratory Medicine
Director or Drug Discovery, Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA
Department: Pathology and Laboratory Medicine

Contact information
Center for Neurodegenerative Disease Research
University of Pennsylvania
3600 Spruce St.
3rd Floor Maloney Bldg.
Philadelphia, PA 19104
Office: 215-615-5262
Education:
B.S. (Biology/Health Chemistry)
Western Michigan University, 1980.
Ph.D. (Biochemistry)
Purdue University, 1985.
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Description of Research Expertise

Dr. Brunden oversees research programs directed towards the identification of therapeutic targets and treatments for Alzheimer's, Parkinson's and other neurodegenerative diseases.

Description of Itmat Expertise

Dr. Brunden oversees research programs directed towards the identification of therapeutic targets and treatments for Alzheimer's, Parkinson's and other neurodegenerative diseases.

Selected Publications

Cornec A-S, James M, Kovalevich J, Trojanowski JQ, Lee VM-Y, Smith AB III, Ballatore C and Brunden KR: Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine. Bioorg. Med. Chem. Lett. in press, 2015.

Sankaranaraynan S, Barten D, Vana L, Devidze N, Yang L, Cadelina G, Hoque N, DeCarr L, Kennan S, Lin A, Cao Y, Snyder B, Zhang B, Nitla M, Hirschfeld G, Barrezueta N, Polson C, Wes P, Rangan V, Cacace A, Albright CF, Meredith J, Trojanowski JQ, Lee V-MY, Brunden KR* and Ahlijanian M* (*Co-corresponding authors): Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. PlosONE 10: e0125614, 2015.

Peeraer E, Bottelbergs A, Van Kolen K, Stancu IC, Vasconcelos B, Mahieu M, Duytschaever H, Ver Donck L, Torremans A, Sluydts E, Van Acker N, Kemp JA, Mercken, M, Brunden KR, Trojanowski JQ, Dewachter I; Lee VM and Moechers D: Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice. Neurobiol. Dis. 73: 83-95, 2015.

65. Lou K, Yao Y, Hoye A, James M, Cornec A, Hyde E, Gay B, Lee VM-Y, Trojanowski JQ, Smith AB III, Brunden KR* and Ballatore C* (*Co-corresponding authors): Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer’s disease and related tauopathies. J. Med. Chem. 57: 6116-27, 2014.

66. Wang X, Liu L, Huang L, Herbst-Robinson K, Cornec A, James M, Sugiyama S, Bassetto M, Brancale A, Trojanowski JQ, Lee VM-Y, Smith AB III, Brunden KR* and Ballatore C* (*Co-corresponding authors): Potent, long-acting cyclopentane-1,3-dione thromboxane (A2) receptor antagonists. ACS Med. Chem. Lett. 5: 1015-20, 2014.

Ballatore C, Gay B, Huang L, Herbst-Robinson K, James M, Trojanowski JQ, Lee VM-Y, Brunden KR and Smith AB III : Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group. Bioorg. Med. Chem. Lett. 24: 4171-75, 2014.

La Pietra Valeria, La Regina Giuseppe, Coluccia Antonio, Famiglini Valeria, Pelliccia Sveva, Plotkin Batya, Eldar-Finkelman Hagit, Brancale Andrea, Ballatore Carlo, Crowe Alex, Brunden Kurt R, Marinelli Luciana, Novellino Ettore, Silvestri Romano: Design, Synthesis, and Biological Evaluation of 1-Phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as New Glycogen Synthase Kinase-3β Inhibitors. Journal of medicinal chemistry 56(24): 10066-78, Dec 2013.

Tanik Selcuk A, Schultheiss Christine E, Volpicelli-Daley Laura A, Brunden Kurt R, Lee Virginia M Y: Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy. The Journal of biological chemistry 288(21): 15194-15210, May 2013.

Crowe Alex, James Michael J, Lee Virginia M-Y, Smith Amos B, Trojanowski John Q, Ballatore Carlo, Brunden Kurt R: Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation. The Journal of biological chemistry 288(16): 11024-37, Apr 2013.

Brunden KR, Gardner NM, James MJ, Yao Y, Trojanowski JQ, Lee VM-Y, Paterson I, Ballatore C and Smith AB III: The microtubule-stabilizing agent, dictyostatin, exhibits prolonged brain retention and activity: potential therapeutic implications. ACS Med. Chem. Lett. 4: 886-89, 2013.

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Last updated: 06/05/2015
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