Kurt R Brunden

faculty photo
Research Professor of Pathology and Laboratory Medicine
Director or Drug Discovery, Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA
Department: Pathology and Laboratory Medicine

Contact information
Center for Neurodegenerative Disease Research
University of Pennsylvania
3600 Spruce St.
3rd Floor Maloney Bldg.
Philadelphia, PA 19104
Office: 215-615-5262
Education:
B.S. (Biology/Health Chemistry)
Western Michigan University, 1980.
Ph.D. (Biochemistry)
Purdue University, 1985.
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Description of Research Expertise

Dr. Brunden oversees research programs directed towards the identification of therapeutic targets and treatments for Alzheimer's, Parkinson's and other neurodegenerative diseases.

Description of Itmat Expertise

Dr. Brunden oversees research programs directed towards the identification of therapeutic targets and treatments for Alzheimer's, Parkinson's and other neurodegenerative diseases.

Selected Publications

La Pietra Valeria, La Regina Giuseppe, Coluccia Antonio, Famiglini Valeria, Pelliccia Sveva, Plotkin Batya, Eldar-Finkelman Hagit, Brancale Andrea, Ballatore Carlo, Crowe Alex, Brunden Kurt R, Marinelli Luciana, Novellino Ettore, Silvestri Romano: Design, Synthesis, and Biological Evaluation of 1-Phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as New Glycogen Synthase Kinase-3β Inhibitors. Journal of medicinal chemistry 56(24): 10066-78, Dec 2013.

Tanik Selcuk A, Schultheiss Christine E, Volpicelli-Daley Laura A, Brunden Kurt R, Lee Virginia M Y: Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy. The Journal of biological chemistry 288(21): 15194-15210, May 2013.

Crowe Alex, James Michael J, Lee Virginia M-Y, Smith Amos B, Trojanowski John Q, Ballatore Carlo, Brunden Kurt R: Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation. The Journal of biological chemistry 288(16): 11024-37, Apr 2013.

Brunden KR, Gardner NM, James MJ, Yao Y, Trojanowski JQ, Lee VM-Y, Paterson I, Ballatore C and Smith AB III: The microtubule-stabilizing agent, dictyostatin, exhibits prolonged brain retention and activity: potential therapeutic implications. ACS Med. Chem. Lett. 4: 886-89, 2013.

Ballatore Carlo, Crowe Alex, Piscitelli Francesco, James Michael, Lou Kevin, Rossidivito Gabrielle, Yao Yuemang, Trojanowski John Q, Lee Virginia M-Y, Brunden Kurt R, Smith Amos B: Aminothienopyridazine inhibitors of tau aggregation: Evaluation of structure-activity relationship leads to selection of candidates with desirable in vivo properties. Bioorganic & medicinal chemistry 20(14): 4451-61, Jul 2012.

Cramer, PE, Cirrito JR, Wesson DW, Lee DCY, Karlo JC, Zinn AE, Casali BT, Restivo JL, Goebel WD, James MJ, Brunden KR, Wilson DA and Landreth GE : ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in mouse models of Alzheimer’s disease. Science In press, 2012.

Soper JH, Sugiyama S, Herbst-Robinson K, James MJ, Wang X, Trojanowski JQ, Smith AB III, Lee VM-Y, Ballatore C and Brunden KR: Brain-penetrant tetrahydronaphthalene thromboxan A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer’s disease. ACS Chem. Neurosci. 3: 928-940, 2012.

Trojanowski JQ, Arnold DE, Karlawish JH, Naylor M, Brunden KR and Lee VM-Y: A model for improving the treatment and care of Alzheimer’s disease patients through interdisciplinary research. Alzheimer’s & Dementia 8: 564-573, 2012.

Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, Hogan AL, Xie SX, Ballatore C, Smith AB III, Lee VMY and Brunden KR : The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, cognitive deficits, neurotoxicity and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J. Neurosci. In press, 2012.

Ballatore Carlo, Soper James H, Piscitelli Francesco, James Michael, Huang Longchuan, Atasoylu Onur, Huryn Donna M, Trojanowski John Q, Lee Virginia M-Y, Brunden Kurt R, Smith Amos B: Cyclopentane-1,3-dione: A Novel Isostere for the Carboxylic Acid Functional Group. Application to the Design of Potent Thromboxane (A2) Receptor Antagonists. Journal of medicinal chemistry 54(19): 6969-83, Oct 2011.

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Last updated: 01/17/2014
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