Bin Chen

faculty photo
Member, ITMAT
Department: Radiation Oncology

Contact information
Philadelphia College of Pharmacy
University of the Sciences in Philadelphia
600 South 43rd Street
Philadelphia, PA 19104
Education:
BS (Pharmacy)
Nanjing University of Chinese Medicine, 1992.
MS (Pharmacology)
Nanjing University of Chinese Medicine, 1995.
Ph.D. (Pharmaceutical Sciences)
Catholic University Leuven, 2002.
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Description of Research Expertise

tumor vascular targeting, photodynamic therapy, tumor imaging, cancer pharmacology

Description of Itmat Expertise

Dr. Chen focuses on the mechanisms of photodynamic therapy in cancer treatments, particularly related to photodynamic tumor vascular targeting. He is currently investigating the mechanism of photodynamic vascular targeting for the treatment of prostate cancer and its interaction with chemotherapy or antibody therapy.

Selected Publications

Li Zhuzhu, Agharkar Priyanka, Chen Bin: Therapeutic enhancement of vascular-targeted photodynamic therapy by inhibiting proteasomal function. Cancer letters 339(1): 128-34, Oct 2013.

Fateye Babasola, Li Weihua, Wang Chenguang, Chen Bin: Combination of phosphatidylinositol 3-kinases pathway inhibitor and photodynamic therapy in endothelial and tumor cells. Photochemistry and photobiology 88(5): 1265-72, Sep-Oct 2012.

Dhupkar Pooja, Dowling Melissa, Cengel Keith, Chen Bin: Effects of anti-EGFR antibody cetuximab on androgen-independent prostate cancer cells. Anticancer research 30(6): 1905-10, Jun 2010.

Chen Bin, Crane Curtis, He Chong, Gondek David, Agharkar Priyanka, Savellano Mark D, Hoopes P Jack, Pogue Brian W: Disparity between prostate tumor interior versus peripheral vasculature in response to verteporfin-mediated vascular-targeting therapy. International journal of cancer. Journal international du cancer 123(3): 695-701, Aug 2008.

He, C., Agharkar, P., Chen, B.: Intravital microscopic analysis of vascular perfusion and macromolecule extravasation after photodynamic vascular targeting therapy. Pharm Res 25(8): 1873-80, 2008.

Zhou Xiaodong, Chen Bin, Hoopes P Jack, Hasan Tayyaba, Pogue Brian W: Peptide-induced inflammatory increase in vascular permeability improves photosensitizer delivery and intersubject photodynamic treatment efficacy. Radiation research 168(3): 299-307, Sep 2007.

Zhou Xiaodong, Chen Bin, Hoopes P Jack, Hasan Tayyaba, Pogue Brian W: Tumor vascular area correlates with photosensitizer uptake: analysis of verteporfin microvascular delivery in the Dunning rat prostate tumor. Photochemistry and photobiology 82(5): 1348-57, Sep-Oct 2006.

Gibbs Summer L, Chen Bin, O'Hara Julia A, Hoopes P Jack, Hasan Tayyaba, Pogue Brian W: Protoporphyrin IX level correlates with number of mitochondria, but increase in production correlates with tumor cell size. Photochemistry and photobiology 82(5): 1334-41, Sep-Oct 2006.

Zhou Xiaodong, Pogue Brian W, Chen Bin, Demidenko Eugene, Joshi Rohan, Hoopes Jack, Hasan Tayyaba: Pretreatment photosensitizer dosimetry reduces variation in tumor response. International journal of radiation oncology, biology, physics 64(4): 1211-20, Mar 2006.

Chen Bin, Pogue Brian W, Luna Jorge M, Hardman Rulon L, Hoopes P Jack, Hasan Tayyaba: Tumor vascular permeabilization by vascular-targeting photosensitization: effects, mechanism, and therapeutic implications. Clinical cancer research : an official journal of the American Association for Cancer Research 12(3 Pt 1): 917-23, Feb 2006.

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Last updated: 07/24/2014
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