Matthew J. Lazzara

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Assistant Professor of Chemical & Biomolecular Engineering
Assistant Professor of Medicine, University of Pennsylvania
Department: Chemical & Biomolecular Engineering

Contact information
Department of Chemical Engineering and Biomolecular Engineering
311A Towne Bldg.
220 S. 33rd Steet
Philadelphia, PA 19104
Office: 215-746-2264
Fax: 215-573-2093
Graduate Group Affiliations
Education:
B.S. (Chemical Engineering)
University of Florida, 1997.
PhD (Chemical Enigineering)
Massachusetts Institute of Technology, 2003.
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Description of Itmat Expertise

Cell signaling, receptor-ligand interactions, targeted therapeutics, cancer biology, computational modeling, systems biology

Selected Publications

Lazzara MJ, Lauffenburger DA: Differential EGFR signaling in lung cancers with kinase-inhibitor-sensitizing mutations, IChe National Meeting, Salt Lake City, UT. Nov 2007.

Lazzara MJ, Lauffenburger DA: Predicting enhanced response to EGFR kinase inhibitors in cancer, Biomedical Engineering Society National Meeting, Los Angeles, CA. Sept 2007.

Lazzara MJ, Deen WM: Model of albumin reabsortption in the proximal tubule. Am J Physiol Renal Physiol 292: F430-F439, 2007.

Hendriks BH, Griffiths GJ, Benson R, Kenyon D, Lazzara MJ, Swinton J, Beck S, Hickinson M, Beusmans JM, Lauffenburger DA, DeGraaf D: Decreased internalization of ErbB1 mutants in lung cancer is linked with a mechanism conferring sensitivity to gefitinib. Syst Biol 153: 457-466, 2006.

Bolton GR, Boesch AW, Lazzara MJ: The effects of flow rate on membrane capacity: Development and application of adsorptive membrane fouling models. J Memb Sci 279: 625-634, 2006.

Lazzara MJ, Jasper PJ, Sorger PK, Lauffenburger DA: Altered EGFR trafficking and signaling in Iressa-sensitive human cell lines, AIChe National Meeting, Cincinnati, OH. Nov 2005.

Jasper PJ, Lazzara MJ, Sorger PK, Luaffenburger DA: Altered EGFR trafficking and signaling in Iressa-sensitive human cell lines, International Conference on Systems Biology (ICSB), Boston, MA. Oct 2005.

James A, Lazzara MJ, Lauffenburger DA, Beusmans J: Modulation of heregulin-induced signaling by an ErbB1 kinase inhibitor, International Conference on Systems Biology, Boston, MA. Oct 2005.

Lazzara MJ, Jasper PJ, Sorger PK, Lauffenburger DA: Altered EGFR trafficking and signaling in Iressa-sensitive human cell lines, Biomedical Engineering Society (BMES) National Meeting, Baltimore, MD. Oct 2005.

Bolton GR, LaCasse D, Lazzara MJ, Kuriyel R: The fiber-coating model of biopharmaceutical depth filtration. AIChe J 51: 2978-2987, 2005.

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Last updated: 06/16/2008
The Trustees of the University of Pennsylvania