Jennifer Wei Zou
Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Faculty Professionalism Committee, Department of Radiation Oncology, PCAM
Member in Senior Governance Committee, Department of Radiation Oncology, PCAM
Medical Physics Residency Director, University of Pennsylvania
Department: Radiation Oncology
Contact information
Perelman Center for Advanced Medicine
3400 Civic Center Blvd
Radiation Oncology, TRC-2 West
Philadelphia, PA 19104
3400 Civic Center Blvd
Radiation Oncology, TRC-2 West
Philadelphia, PA 19104
Email:
wei.zou@uphs.upenn.edu
wei.zou@uphs.upenn.edu
Education:
BS (Physics)
Nanjing University, 1993.
PhD (Theoretical and Applied Mechanics)
Cornell University, 2001.
MS (Medical Physics)
University of Pennsylvania, 2010.
BS (Physics)
Nanjing University, 1993.
PhD (Theoretical and Applied Mechanics)
Cornell University, 2001.
MS (Medical Physics)
University of Pennsylvania, 2010.
Post-Graduate Training
Fellow in Medical Physics, University of Pennsylvania, 2008-2010.
Intern in Medical Physics, Vassar Brothers Hospital, 2009-2010.
Resident in Medical Physics, University of Pennsylvania, 2010-2012.
Permanent linkFellow in Medical Physics, University of Pennsylvania, 2008-2010.
Intern in Medical Physics, Vassar Brothers Hospital, 2009-2010.
Resident in Medical Physics, University of Pennsylvania, 2010-2012.
Description of Itmat Expertise
I am interested in translational research on tumor and organ radiotherapy responses with functional imaging and biological modelling.Selected Publications
Tan H S, Teo B K, Lei D, Friberg A, Koumenis C, Diffenderfer E S and Zou W: Modeling ultra-high dose rate electron and proton FLASH effect with the physicochemical approach. Physics in Medicine & Biology July 2023.Zou W, Zhang R, Schueler E, Taylor P A, Mascia A E, Diffenderfer E S, Zhao T, Ayan A S, Sharma M, Yu S-J, Lu W, Bosch W R, Tsien C, Surucu M, Pollard-Larkin J M, Schuemann J, Moros E G, Bazalova-Carter M, Gladstone D J, Li H, Simone C B, Petersson K, Kry S F, Maity A, Loo B W, Dong L, Maxim P G, Xiao Y and Buchsbaum J C: Framework for Quality Assurance of Ultra-High Dose Rate Clinical Trials Investigating FLASH Effects and Current Technology Gaps. Int. J. of Rad. Onc. Bio. Phy. Apr 2023.
Zhang D, Li A M, Hu G, Huang M, Yang F, Zhang L, Wellen K E, Xu X, Conn C S, Zou W, Kahn M, Rhoades S D, Weljie A M, Fuchs S Y, Amankulor N, Yoshor D, Ye J, Koumenis C, Gong Y and Fan Y: PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy. Cell Metabolism 35(2), Feb 2023.
Kim M, Zou W: Ultra-high dose rate FLASH radiation therapy for cancer. Medical Physics 2023.
Yegya-Raman N, Kegelman T P, Ho Lee S, Kallan M J, Kim K N, Natarajan J, Deek M P, Zou W, O’Reilly S E, Zhang Z, Levin W, Cengel K, Kao G, Cohen R B, Sun L L, Langer C J, Aggarwal C, Singh A P, O’Quinn R, Ky B, Apte A, Deasy J, Xiao Y, Berman A T, Jabbour S K and Feigenberg S J: Death without progression as an endpoint to describe cardiac radiation effects in locally advanced non-small cell lung cancer Clinical and Translational Radiation Oncology 39(100581), 2023.
Vallabhaneni S, Wang Y, Zhang Y, Smith A, Zou W, Feigenberg S, Plastaras, J, Freedman G, Witschey WR, Ky B, Han Y: Cardiovascular Magnetic Resonance in Early Detection of Radiation Associated Cardiotoxicity with Chest Radiation. Frontiers in Cardiovascular Medicine May 2022.
Pakela J, Dong L, Rucinski A, Knopf AC, Zou W: Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future. Frontiers in Oncology Mar 2022.
Zou W, Kim H, Diffenderfer E S, Carlson D J, Koch C J, Xiao Y, Teo B K, Kim M M, Metz J M, Fan Y, Maity A, Koumenis C, Busch T M, Wiersma R, Cengel K A and Dong L: A phenomenological model of proton FLASH oxygen depletion effects depending on tissue vasculature and oxygen supply. Frontiers in Oncology 12, 2022.
Zou W and Mihailidis DN: Modelling Radiotherapy Side Effects. Med. Phys. Jul 2021 Notes: https://doi.org/10.1002/mp.15004.
Yang F, He Z, Duan H, Zhang D, Li J, Yang H, Dorsey J F, Zou W, Ali Nabavizadeh S, Bagley S J, Abdullah K, Brem S, Zhang L, Xu X, Byrne K T, Vonderheide R H, Gong Y and Fan Y: Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Nature Communications 12(1), June 2021 Notes: https://doi.org/10.1038/s41467-021-23832-3.