Amy S. Clark
Assistant Professor of Medicine (Hematology-Oncology) at the Hospital of the University of Pennsylvania
Attending, Hospital of the University of Pennsylvania
Physician Lead, Breast Cancer Clinical Research Unit, University of Pennsylvania, Abramson Cancer Center
Department: Medicine
Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-154
3400 Civic Center Boulevard
Philadelphia, PA 19104
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-154
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-662-7096
Fax: 215-615-3349
Fax: 215-615-3349
Email:
amy.clark@uphs.upenn.edu
amy.clark@uphs.upenn.edu
Education:
BS (Biology)
Haverford College, 1999.
MD (Medicine)
Milton S. Hershey Penn State College of Medicine, 2006.
MSCE (Clinical Epidemiology)
University of Pennsylvania, 2012.
BS (Biology)
Haverford College, 1999.
MD (Medicine)
Milton S. Hershey Penn State College of Medicine, 2006.
MSCE (Clinical Epidemiology)
University of Pennsylvania, 2012.
Post-Graduate Training
Intern, Internal Medicine, Boston Medical Center, 2006-2007.
Resident, Internal Medicine, Boston Medical Center, 2007-2009.
Fellow, Hematology/Oncology, Hospital of the University Pennsylvania, 2009-2012.
Permanent linkIntern, Internal Medicine, Boston Medical Center, 2006-2007.
Resident, Internal Medicine, Boston Medical Center, 2007-2009.
Fellow, Hematology/Oncology, Hospital of the University Pennsylvania, 2009-2012.
Description of Itmat Expertise
breast cancerDescription of Research Expertise
My research focuses on clinical trials and drug development for those with early stage and metastatic breast cancer. I also seek to develop novel predictive biomarkers specifically using molecular imaging as companions to early phase trials.Selected Publications
Slavkova KP, McDonald ES, Cohen EA, Pantalone L, Bayne L, Nivar I, Sanchez P, Mankowski WC, Brown M, Clark AS, Rohn K, Chodosh LA, Kontos D, DeMichele A: Evaluating the association between radiomic features on breast MRI and dormant tumor cell presence in the SURMOUNT Trial. Annual Meeting of the American Society of Clinical Oncology June 2024.Giridhar, K., Clark, A: Molecular profiling of serial liquid biopsy specimens utilizing cell free DNA (cfDNA) and circulating tumor cells (CTCs) in TBCRC041: A phase II study of alisertib in endocrine resistant metastatic breast cancer (MBC). Annual Meeting of the American Society of Clinical Oncology June 2024.
Lynce, F., Stevens, L. E., Li, Z., Brock, J. E., Gulvady, A., Huang, Y., Nakhlis, F., Patel, A., Force, J. M., Haddad, T. C., Ueno, N., Stearns, V., Wolff, A. C., Clark, A. S., Bellon, J. R., Richardson, E. T., Balko, J. M., Krop, I. E., Winer, E. P., Lange, P., Hwang E. S., King, T. A., Tolaney, S. M., Thompson, A., Gupta, G. P., Mittendorf, E. A., Regan, M. M., Overmoyer, B., Polyak, K: TBCRC 039: A phase II study of preoperative ruxolitinib with or without paclitaxel for triple-negative inflammatory breast cancer. Breast Cancer Research January 2024.
Albain K, Yau C, Petricoin E, Wolf D, Lang J, Chien A, Haddad T, Forero-Torres A, Wallace A, Kaplan H, Pusztai L, Euhus D, Nanda R, Elias A, Clark A, Godellas C, Boughey J, Isaacs C, Tripathy D, Lu J, Yung R, Gallagher R, Wulfkuhle J, Swigart LB, Krings G, Chen YY, Potter D, Stringer-Reasor E, Blair S, Asare S, Wilson A, Hirst G, Singhrao R, Buxton M, Clennell J, Sanil A, Berry S, Asare A, Matthews J, DeMichele A, Hylton N, Melisko M, Perlmutter J, Rugo H, Symmans W, Van't Veer L, Yee D, Berry D, Esserman L: Neoadjuvant trebananib plus paclitaxel-based chemotherapy for stage II/III breast cancer in the adaptively randomized I-SPY2 trial — Efficacy and biomarker discovery. Clinical Cancer Research January 2024 Notes: Under Review
Zhang, H., Clark, A.S., : A quantitative bias analysis approach to informative presence bias in electronic health records. Epidemiology 2023; In Press.
Fraietta J, Fengjuan Z, Clark A, Taunk N, Xu H N, Gonzalves D, Ahmad Z, Minn A, Huang A, Nayak A, Tchou J: A high pre-existing TCR repertoire diversity may predict response to preoperative radiotherapy and pembrolizumab in early-stage breast cancer –NCT04454528 preliminary results. Society of Surgical Oncology 2023, in press.
Kyalwazi B, Yau C, Campbell MJ, Yoshimatsu TF, Chein AJ, Wallace AM, Forero-Torres A, Pusztai L, Ellis ED, Albain KS, Blaes AH, Haley BB, Boughey JC, Elias AD, Clark AS, Isaacs CJ, Nanda R, Han HS, Yung RL, Tripathy D, Edminston KK, Viscusi RK, Northfelt DW, Khan QJ, Asare SM, Wilson A, Hirst GL, Lu R, Symmans WF, Yee D, DeMichele A, Van't Veer LJ, Esserman LJ, Olopade OI: Race, Gene Expression Signatures, and Clinical Outcomes of Patients With High-Risk Early Breast Cancer. JAMA Network Open Dec 2023.
Amy S. Clark.: "NRG-BR009: Phase III Trial Evaluating Addition of Adjuvant Chemotherapy to Ovarian Function Suppression + Endocrine Therapy in Premenopausal Women with pN0-1, HR+/HER2- Breast Cancer and Oncotype Recurrence Score ≤25 (OFSET)". San Antonio Breast Cancer Symposium BR009 Spotlight, San Antonio, TX. Dec 2023 Notes: "Oral Presentation"
Ulaner GA, Fowler AM, Clark AS, Linden H: Estrogen Receptor-Targeted and Progesterone Receptor-Targeted PET for Patients with Breast Cancer. PET Clin 18(4): 531-542, Oct 2023.
Amy Sanders Clark, Fengmin Zhao, Paula Klein, Alberto J. Montero, Carla Isadora Falkson, Elisa Krill-Jackson.: "BRACELET-1 (PrE0113): Inducing an inflammatory phenotype in metastatic HR+/HER2- breast cancer with the oncolytic reovirus pelareorep in combination with paclitaxel and avelumab". The Dr. Bernard Fisher Memorial Annual Clinical Science Symposium, ASCO Annual Meeting, Chicago, IL. Jun 2023 Notes: "Oral Presentation"