James E Schmitt

faculty photo
Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Attending Neuroradiology, Hospital of the University of Pennsylvania, Philadelphia PA
Attending Neuroradiology, Pennsylvania Hospital, Philadelphia, PA
Attending Neuroradiology, Penn Presbyterian Medical Center, Philadelphia, PA
Active Medical Staff Radiology, Chester County Hospital, West Chester, PA
Department: Radiology

Contact information
Department of Radiology
Division of Neuroradiology
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Education:
A.B. (Psychology)
Stanford University , 1998.
B.S. (Biological Sciences)
Stanford University , 1998.
Ph.D. (Human and Molecular Genetics, Quantitative Track)
Medical College of Virginia, 2008.
M.D.
Medical College of Virginia , 2008.
Post-Graduate Training
Internal Medicine Intern, Yale University, New Haven, CT, 2009-2010.
Radiology Resident , Hospital of the University of Pennsylvania, Philadelphia, PA , 2010-2014.
Research Fellow, Psychiatry-Brain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA , 2013-2016.
Imaging Informatics Fellow, Hospital of the University of Pennsylvania, Philadelphia, PA , 2013-2014.
Chief Resident, Hospital of the University of Pennsylvania, Philadelphia, PA, 2013-2014.
Neuroradiology Fellow, Hospital of the University of Pennsylvania, Philadelphia, PA, 2014-2015.
Permanent link
 
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Description of Itmat Expertise

Neurogenetics
Quantitative neuroimaging
Quantitative genetics
Psychosis
Typical Neurodevelopment

Description of Research Expertise

Neuroradiology, Neurogenetics, Quantitative Genetics

Selected Publications

Schmitt JE, Raznahan A, Clasen LS, Wallace GL, Pritikin JN, Lee NR, Giedd JN, Neale MC : The Dynamic Associations Between Cortical Thickness and General Intelligence are Genetically-Mediated. Cerebral Cortex 29(11): 4743-4752, Dec 2019 Notes: PMID: 30715232 PMCID: PMC6917515 DOI: 10.1093/cercor/bhz007.

Xia K, Schmitt JE, Jha SC, Girault JB, Cornea E, Li G, Shen D, Styner M, Gilmore JH: Genetic Influences on Longitudinal Trajectories of Cortical Thickness and Surface Area During the First Two Years of Life. Cerebral Cortex 32(2): 367-379, Jan 2022 Notes: PMID: 34231837 PMCID: PMC8897991 DOI: 10.1093/cercor/bhab213.

Schmitt JE, Neale MC, Clasen LS, Liu S, Seidlitz J, Pritikin JN, Chu A, Wallace GL, Lee NR, Giedd JN, Raznahan A: A Comprehensive Quantitative Genetic Analysis of Cerebral Surface Area in Youth. Journal of Neuroscience 39(16): 3028-3040, Apr 2019 Notes: PMID: 30833512 PMCID: PMC6468099 DOI: 10.1523/JNEUROSCI.2248-18.2019.

Sun D, Ching CRK, Lin A, Forsyth JK, Kushan L, Vajdi A, Jalbrzikowski M, Hansen L, Villalon-Reina JE, Qu X, Jonas RK, van Amelsvoort T, Bakker G, Kates WR, Antshel KM, Fremont W, Campbell LE, McCabe KL, Daly E, Gudbrandsen M, Murphy CM, Murphy D, Craig M, Vorstman J, Fiksinski A, Koops S, Ruparel K, Roalf DR, Gur RE, Schmitt JE, Simon TJ, Goodrich-Hunsaker NJ, Durdle CA, Bassett AS, Chow EWC, Butcher NJ, Vila-Rodriguez F, Doherty J, Cunningham A, van den Bree MBM, Linden DEJ, Moss H, Owen MJ, Murphy KC, McDonald-McGinn DM, Emanuel B, van Erp TGM, Turner JA, Thompson PM, Bearden CE: Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size. Molecular Psychiatry 25(8): 1822-1834, August 2020 Notes: PMID: 29895892 PMCID: PMC6292748 DOI: 10.1038/s41380-018-0078-5.

Schmitt JE, Raznahan A, Liu S, Neale MC: The Genetics of Cortical Myelination in Young Adults and its Relationships to Cerebral Surface Area, Cortical Thickness, and Intelligence: a Magnetic Resonance Imaging Study of Twins and Families. NeuroImage 206: 116319, February 2020 Notes: PMID: 31678229 PMCID: PMC7871660 DOI: 10.1016/j.neuroimage.2019.116319.

Villalón-Reina JE, Martínez K, Qu X, Ching CRK, Nir TM, Kothapalli D, Corbin C, Sun D, Lin A, Forsyth JK, Kushan L, Vajdi A, Jalbrzikowski M, Hansen L, Jonas RK, van Amelsvoort T, Bakker G, Kates WR, Antshel KM, Fremont W, Campbell LE, McCabe KL, Daly E, Gudbrandsen M, Murphy CM, Murphy D, Craig M, Emanuel B, McDonald-McGinn DM, Vorstman JAS, Fiksinski AM, Koops S, Ruparel K, Roalf D, Gur RE, Eric Schmitt J, Simon TJ, Goodrich-Hunsaker NJ, Durdle CA, Doherty JL, Cunningham AC, van den Bree M, Linden DEJ, Owen M, Moss H, Kelly S, Donohoe G, Murphy KC, Arango C, Jahanshad N, Thompson PM, Bearden CE: Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study. Molecular Psychiatry 25(11): 2818-2831, November 2020 Notes: originally published online 7/2019.

Rosen AF, Roalf DA, Ruparel K, Blake J, Seelaus K, villa P, Cook PA, Davatzikos C, Elliot MA, Garcia de La Garza A, Gennatas ED, Quarmley M, Schmitt JE, Shinohara, Tisdall MD, Craddock C, Gur RE, Gur RC, Satterthwaite TD: Quantitative assessment of structural image quality. NeuroImage 169(1): 407-418, 2018 Notes: PMID: 29278774 PMCID: PMC5856621 DOI: 10.1016/j.neuroimage.2017.12.059.

Schmitt JE, Raznahan A, Liu S, Neale MC: The Heritability of Cortical Folding: Evidence from the Human Connectome Project. Cerebral Cortex 31(1): 702-715, January 2021 Notes: PMID: 32959043 PMCID: PMC7727360 DOI: 10.1093/cercor/bhaa254.

Schmitt JE, Giedd JN, Raznahan A, Neale MC.: The Genetic Contributions to Maturational Coupling in the Human Cerebrum; A Longitudinal Pediatric Twin Imaging Study Cerebral Cortex Page: 3184-3191, 2018 Notes: PMID: 28968785 PMCID: PMC6095207 DOI: 10.1093/cercor/bhx190.

Schabdach JM, Schmitt JE, Sotardi S, Vossough A, Andronikou S, Roberts TP, Huang H, Padmanabhan V, Ortiz-Rosa A, Gardner M, Covitz S, Bedford SA, Mandal AS, Chaiyachati BH, White SR, Bullmore E, Bethlehem RAI, Shinohara RT, Billot B, Iglesias JE, Ghosh S, Gur RE, Satterthwaite TD, Roalf D, Seidlitz J, Alexander-Bloch A: Brain Growth Charts for Quantitative Analysis of Pediatric Clinical Brain MRI Scans with Limited Imaging Pathology. Radiology 309(1): e230096, Oct 2023 Notes: PMID: 37906015 PMCID: PMC10623207 (available on 2024-10-01) DOI: 10.1148/radiol.230096.

Ching CRK, Gutman BA, Sun D, Villalon Reina J, Ragothaman A, Isaev D, Zavaliangos-Petropulu A, Lin A, Jonas RK, Kushan L, Pacheco-Hansen L, Vajdi A, Forsyth JK, Jalbrzikowski M, Bakker G, van Amelsvoort T, Antshel KM, Fremont W, Kates WR, Campbell LE, McCabe KL, Craig MC, Daly E, Gudbrandsen M, Murphy CM, Murphy DG , Murphy KC, Fiksinski A, Koops S, Vorstman J, Crowley TB, Emanuel BS, Gur RE, McDonald-McGinn DM, Roalf D, Ruparel K, Schmitt JE, Zackai EH, Durdle CA, Goodrich-Hunsaker NJ, Simon TJ, Bassett AS, Butcher NJ, Chow EWC, Vila-Rodriguez F, Cunningham A, Doherty J , Linden DE, Moss H, Owen MJ, van den Bree M, Crossley NA, Repetto GM, Thompson PM, Bearden CE: Mapping Subcortical Brain Alterations in 22q11.2 Deletion Syndrome: Effects of Deletion Size and Convergence With Idiopathic Neuropsychiatric Illness. American Journal of Psychiatry 177(7): 589-600, Jul 2020 Notes: PMID: 32046535 PMCID: PMC7419015 DOI: 10.1176/appi.ajp.2019.19060583.

Jha SC, Xia K, Schmitt JE, Ahn M, Girault JB, Murphy VA, Li G, Wang L, Shen D, Zou F, Zhu H, Styner M, Knickmeyer RC, Gilmore JH: Genetic influences on neonatal cortical thickness and surface area. Human Brain Mapping 39(12): 4998-5013, 2018 Notes: PMID: 30144223 PMCID: PMC6218288 DOI: 10.1002/hbm.24340.

Forsyth JK, Mennigen E, Lin A, Sun D, Vajdi A, Kushan-Wells L, Ching CRK, Villalon-Reina JE, Thompson PM, Jonas RJ, Pacheco-Hansen L, Bakker G, van Amelsvoort T, Antshel KM, Fremont W, Kates WR, Campbell LE, McCabe KL, Craig MC, Daly E, Gudbrandsen M, Murphy CM, Murphy DG, Murphy KC, Fiksinski A, Koops S, Vorstman J, Crowley TB, Emanuel BS, Gur RE, McDonald-McGinn DM, Roalf DR, Ruparel K, Schmitt JE, Zackai EH, Durdle CA, Goodrich-Hunsaker NJ, Simon TJ, Bassett AS, Butcher NJ, Chow EWC, Vila-Rodriguez F, Cunningham A, Doherty JL, Linden DE, Moss H, Owen MJ, van den Bree M, Crossley NA, Repetto GM, Bearden CE: Prioritizing Genetic Contributors to Cortical Alterations in 22q11.2 Deletion Syndrome Using Imaging Transcriptomics. Cerebral Cortex 31(7): 3258-3298, Jun 2021 Notes: PMID: 33638978 PMCID: PMC8196250 DOI: 10.1093/cercor/bhab008.

Schmitt JE, Vandekar S, Yi J, Ruparel K, Roalf DR, Whinna D, Souders MC, Satterwaite TD, Prabhakaran K, McDonald-McGinn DM, Zakhai EH, Gur RC, Emanuel BS, Gur RE.: Aberrant Cortical Morphometry in the 22q11.2 Deletion Syndrome Biological Psychiatry 78(2): 135-143, Nov 2014 Notes: PMID: 25555483 PMCID: PMC4446247 DOI: 10.1016/j.biopsych.2014.10.025.

Schmitt JE, Neale MC, Fassassi B, Perez J, Lenroot R, Wells E, Giedd JN. : The dynamic role of genetics on cortical patterning during childhood and adolescence. Proceedings of the National Academy of Sciences of the USA 111(18): 6774-6779, April 2014 Notes: PMID: 24753564 PMCID: PMC4020057 DOI: 10.1073/pnas.1311630111.

Eyler LT, Prom-Wormley E, Fennema-Notestine C, Fischl B, Franz CE, Lyons MJ, Makris N, Neale MC, Pacheco J, Perry ME, Panizzon MS, Schmitt JE, Seidman LJ, Thermenos H, TsuangMT, Dale AM, Kremen WS.: Genetic patterns of correlation among subcortical volumes in humans: Results from a magnetic resonance imaging twins study Human Brain Mapping 32(4): 641-653, Apr 2011 Notes: PMID: 20572207 PMCID: PMC3403693 DOI: 10.1002/hbm.21054.

Rimol LM, Kremen W, Hagler D, Fennema-Notestine C, Eyler LT, Panizzon M, Neale MC, Schmitt JE, Lyons MJ, Franz CE, Fischl B, Seidman LJ, Makris N, Perry M, Pecheco J, Dale A. : Heritability of cortical thickness in a large adult twin sample: The VETSA Project Human Brain Mapping (HBM) 2007 Notes: Poster Presentation.

Schmitt JE, Lenroot RK, Wallace GL, Ordaz S, Taylor KN, Kabani N, Greenstein D, Lerch JP, Kendler KS, Neale MC, Giedd JN: Identification of genetically mediated cortical networks: a multivariate study of pediatric twins and siblings. Cerebral Cortex 18(8): 1737-1747, Jan 2008 Notes: PMID: 18234689 PMCID: PMC2790393 DOI: 10.1093/cercor/bhm211.

Kendler KS, Schmitt JE, Aggen SA, Prescott CA: Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use across the life cycle Archives of General Psychiatry 65(6): 674-682, June 2008 Notes: PMID: 18519825 PMCID: PMC2844891 DOI: 10.1001/archpsyc.65.6.674.

Schmitt JE, Lenroot RK, Ordaz SE, Wallace GL, Lerch JP, Evans AC, Prom EC, Kendler KS, Neale MC, Giedd JN: Variance decomposition of MRI-based covariance maps using genetically informative samples and structural equation modeling. NeuroImage 47(1): 56-64, Aug 2009 Notes: PMID: 18672072 PMCID: PMC2996833 DOI: 10.1016/j.neuroimage.2008.06.039.

Dinglasan LA, Oh J, Schmitt JE, Trerotola SO, Stavropoulos, SW: Complicated inferior vena cava filter retrievals: associated factors identified at preretrieval CT. Radiology 266(1): 347-354, Jan 2013 Notes: PMID: 23047840 DOI: 10.1148/radiol.12120372.

Gilmore JH, Schmitt JE, Knickmeyer RC, Smith JK, Lin W, Styner M, Gerig G, Neale MC: Genetic and environmental contributions to neonatal brain structure: A twin study. Human Brain Mapping 31(8): 1174-1182, Aug 2010.

Schmitt JE, Wallace GL, Rosenthal MA, Ordaz, S.J., Malloy EA, Clasen LS, Blumenthal JD, Rose AB, Kendler KS, Neale MC, Giedd, JN: Multivariate analyses of neuroanatomy in a genetically informative pediatric sample. NeuroImage 35(1): 70-82, March 2007 Notes: PMID: 17208460 DOI: 10.1016/j.neuroimage.2006.04.232.

Eliez S, Barnea-Goraly N, Schmitt JE, Liu Y, Reiss AL: Increased basal ganglia volumes in velo-cardio-facial syndrome (deletion 22q11.2). Biological Psychiatry 1(52): 68-70, July 2002 Notes: PMID: 12079732 DOI: 10.1016/s0006-3223(02)01361-6.

Galaburda A, Schmitt JE, Atlas SW, Eliez S, Bellugi U, Reiss AL.: Dorsal Forebrain Anomaly in Williams Syndrome Archives of Neurology 58(11): 1865-1869, Nov 2001 Notes: PMID: 11708996 DOI: 10.1001/archneur.58.11.1865.

Eliez S, Schmitt JE, White CD, Wellis VG, Reiss AL: A Quantitative MRI study of Posterior Fossa Development in Velo-cardio-facial Syndrome. Biological Psychiatry 49(6): 540-546, March 2001 Notes: PMID: 11257239 DOI: 10.1016/s0006-3223(00)01005-2.

Pinter J, Eliez S, Schmitt JE, Capone G, Reiss AL: Neuroanatomy of Down Syndrome: A High-Resolution MRI Study. American Journal of Psychiatry 158: 1659-1665, Oct 2001 Notes: PMID: 11578999 DOI: 10.1176/appi.ajp.158.10.1659.

Eliez S, Schmitt JE, White CD, Reiss AL: Children and Adolescents with Velo-Cardio-Facial Syndrome: a Volumetric MRI Study. American Journal of Psychiatry 157(3): 409-415, March 2000 Notes: PMID: 10698817 DOI: 10.1176/appi.ajp.157.3.409.

Fennema-Notestine C, Eyler LT, Schmitt JE, Lyons MJ, Franz CE, Eisen SA, Fischl B, Seidman LJ, Makris N, Neale M, Thermenos H, Perry M, Pacheco J, Grant M, Tsuang MT, Dale A, Kremen WS. : Genetic and Environmental Influences on Brain Structures in 320 Adult Twins: The VETSA Project. Human Brain Mapping (HBM) 2007 Notes: Poster Presentation.

Yushkevich PA, Pashchinskiy A, Oguz I, Mohan S, Schmitt JE, Stein JM, Zukić D, Vicory J, McCormick M, Yushkevich N, Schwartz N, Gao Y, Gerig G: User-Guided Segmentation of Multi-modality Medical Imaging Datasets with ITK-SNAP. Neuroinformatics 17(1): 83-102, Jan 2019 Notes: PMID: 29946897 PMCID: PMC6310114 DOI: 10.1007/s12021-018-9385-x.

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Last updated: 04/04/2024
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