David B. Roth
Emeritus Professor of Pathology and Laboratory Medicine
Chair, Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania
Member, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania
Member, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania
Founding Director, Precision Medicine Program, Penn Medicine
Professor of Pathobiology, University of Pennsylvania School of Veterinary Medicine
Department: Pathology and Laboratory Medicine
Contact information
6.036 Gates Building
3400 Spruce Street
Philadelphia, PA 19104-4283
3400 Spruce Street
Philadelphia, PA 19104-4283
Office: 215-615-6510
Fax: 215-662-4063
Fax: 215-662-4063
Links
Online interview: "An interview with Dr. David Roth – Penn Medicine – Tackling the challenges of leveraging genomic data across both research and clinical settings at Penn Medicine", The Journal of Precision Medicine, March 2016
"Former Penn professor and 1952 Penn Medicine grad who revolutionized cancer research has died", article in The Daily Pennsylvanian reporting on the death of Peter C. Nowell, MD
Roth Lab Website
Penn Center for Precision Medicine
WHYY interview for The Pulse: POTUS: Precision Medicine Initiative will bring us closer to a cancer cure — NewsWorks
News Coverage: "Penn Cancer Center Looks to Expanded Gene Testing" Philadelphia Inquirer, August 9, 2013.
Online interview: "An interview with Dr. David Roth – Penn Medicine – Tackling the challenges of leveraging genomic data across both research and clinical settings at Penn Medicine", The Journal of Precision Medicine, March 2016
"Former Penn professor and 1952 Penn Medicine grad who revolutionized cancer research has died", article in The Daily Pennsylvanian reporting on the death of Peter C. Nowell, MD
Roth Lab Website
Penn Center for Precision Medicine
WHYY interview for The Pulse: POTUS: Precision Medicine Initiative will bring us closer to a cancer cure — NewsWorks
News Coverage: "Penn Cancer Center Looks to Expanded Gene Testing" Philadelphia Inquirer, August 9, 2013.
Education:
BA (Biochemistry)
Rice University, Houston TX, 1981.
MD (with High Honors)
Baylor College of Medicine, Houston TX, 1986.
PhD (Biochemistry)
Baylor College of Medicine, Houston TX, 1988.
BA (Biochemistry)
Rice University, Houston TX, 1981.
MD (with High Honors)
Baylor College of Medicine, Houston TX, 1986.
PhD (Biochemistry)
Baylor College of Medicine, Houston TX, 1988.
Post-Graduate Training
Postdoctoral Fellow, Biochemistry, Baylor College of Medicine, Houston TX, 1986-1986.
Resident, Anatomic Pathology, National Cancer Institute, Bethesda MD, 1988-1991.
Postdoctoral Fellow, Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda MD, 1990-1993.
Permanent linkPostdoctoral Fellow, Biochemistry, Baylor College of Medicine, Houston TX, 1986-1986.
Resident, Anatomic Pathology, National Cancer Institute, Bethesda MD, 1988-1991.
Postdoctoral Fellow, Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda MD, 1990-1993.
Description of Itmat Expertise
Identifying actionable mutations in canine hemangiosarcoma to enable clinical trials and to potentially apply this knowledge to human angiosarcoma.Description of Other Expertise
Director, Penn Center for Precision MedicinePanelist, Panel Discussion at Penn Medicine Advances: "Pathways Leading to Cures", Merion, PA, November, 2013
Selected Publications
Luskin MR, Carroll M, Lieberman D, Morrissette JJD, Zhao J, Crisalli L, Roth DB, Luger SM, Porter DL, Reshef D: Clinical utility of next-generation sequencing for oncogenic mutations in patients with acute myeloid leukemia undergoing allogenic stem cell transplantation. Biology of Blood and Marrow Transplantation 22: 1961-67, Sept 2016.Hiemenz MC, Kadauke S, Lieberman DB, Roth DB, Zhao J, Watt CD, Daber RD, Morrissette JJ: Building a Robust Tumor Profiling Program: Synergy between Next-Generation Sequencing and Targeted Single-Gene Testing. PLoS One 11(4): e0152851, Apr 2016 Notes: doi: 10.1371/journal.pone.0152851. eCollection 2016.
Roth D: Young but Powerful: Penn Medicine’s Center for Personalized Diagnostics is on a mission to improve patient care using the power of genomics. The Pathologist(0316), 402, March 2016 Notes: https://thepathologist.com/issues/0316/young-but-powerful/
Lescale C, Abramowski V, Bedora-Faure M, Murigneux V, Vera G, Roth DB, Revy P, de Villartay JP, Deriano L: RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair. Nat Commun 7(10529), Feb 2016.
Wei S, Lieberman D, Morrissette JJ, Baloch ZW, Roth DB, McGrath C: Using "residual" FNA rinse and body fluid specimens for next-generation sequencing: An institutional experience. Cancer Cytopathol Dec 2015.
Martina Mijušković, Yi-Fan Chou Vered Gigi, Cory R. Lindsay, Olga Shestova, Susanna M. Lewis, David B. Roth: Off target V(D)J recombination drives lymphomagenesis and is escalated by loss of the Rag2 C-terminus. Cell Reports 12: 1842-1852, Sept 2015 Notes: 10.1016/j.celrep.2015.08.034
Corrigan-Curay Jacqueline, O'Reilly Marina, Kohn Donald B, Cannon Paula M, Bao Gang, Bushman Frederic D, Carroll Dana, Cathomen Toni, Joung J Keith, Roth David, Sadelain Michel, Scharenberg Andrew M, von Kalle Christof, Zhang Feng, Jambou Robert, Rosenthal Eugene, Hassani Morad, Singh Aparna, Porteus Matthew H: Genome Editing Technologies: Defining a Path to Clinic. Molecular therapy: the journal of the American Society of Gene Therapy 23(5): 796-806, May 2015.
Wilson Melissa A, Morrissette Jennifer J D, McGettigan Suzanne, Roth David, Elder David, Schuchter Lynn M, Daber Robert D: What you are missing could matter: a rare, complex BRAF mutation affecting codons 599, 600, and 601 uncovered by next generation sequencing. Cancer genetics Jun 2014.
Gigi V, Lewis S, Shestova O, Mijušković M, Deriano L, Meng W, Luning Prak ET, Roth DB: RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of 'alternative NHEJ' Nucleic Acids Research 42(10): 6352-64, April 2014 Notes: doi: 10.1093/nar/gku25.