Robert H Mach

faculty photo
Britton Chance Professor of Radiology
Director, Radiochemistry Research, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
Department: Radiology

Contact information
Department of Radiology
Chemistry Building
231 S. 34th Street
Philadelphia, PA 19104
Office: 215-746-8233
Graduate Group Affiliations
B.A. (Chemistry)
State University of New York, College at Potsdam, 1978.
Ph.D. (Medical Chemistry)
State University of New York at Buffalo, Buffalo, NY, 1985.
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Description of Itmat Expertise

Tumor proliferation and quiescence, positron emission tomography, neurodegenerative disorders, addiction research

Selected Publications

Malik Maninder, Rangel-Barajas Claudia, Mach Robert H, Luedtke Robert R: The effect of the sigma-1 receptor selective compound LS-1-137 on the DOI-induced head twitch response in mice. Pharmacology, biochemistry, and behavior 148: 136-44, Sep 2016.

Makvandi Mehran, Xu Kuiying, Lieberman Brian P, Anderson Redmond-Craig, Effron Samuel Sander, Winters Harrison D, Zeng Chenbo, McDonald Elizabeth S, Pryma Daniel A, Greenberg Roger A, Mach Robert H: A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy. Cancer research 76(15): 4516-24, Aug 2016.

Ohman Kerri A, Hashim Yassar M, Vangveravong Suwanna, Nywening Timothy M, Cullinan Darren R, Goedegebuure S Peter, Liu Jingxia, Van Tine Brian A, Tiriac Herve, Tuveson David A, DeNardo David G, Spitzer Dirk, Mach Robert H, Hawkins William G: Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic. Oncotarget May 2016.

Zeng Chenbo, Garg Neha, Mach Robert H: The PGRMC1 Protein Level Correlates with the Binding Activity of a Sigma-2 Fluorescent Probe (SW120) in Rat Brain Cells. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 18(2): 172-9, Apr 2016.

McDonald Elizabeth S, Mankoff David A, Mach Robert H: Novel Strategies for Breast Cancer Imaging: New Imaging Agents to Guide Treatment. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 57 Suppl 1: 69S-74S, Feb 2016.

Makvandi Mehran, Lieberman Brian P, LeGeyt Ben, Hou Catherine, Mankoff David A, Mach Robert H, Pryma Daniel A: The pre-clinical characterization of an alpha-emitting sigma-2 receptor targeted radiotherapeutic. Nuclear medicine and biology 43(1): 35-41, Jan 2016.

Ikome Hermia N, Ntie-Kang Fidele, Ngemenya Moses N, Tu Zhude, Mach Robert H, Efange Simon M N: 4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies. Chemistry Central journal 10(1): 53, 2016.

Edmonds Christine E, Makvandi Mehran, Lieberman Brian P, Xu Kuiying, Zeng Chenbo, Li Shihong, Hou Catherine, Lee Hsiaoju, Greenberg Roger A, Mankoff David A, Mach Robert H: [(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer. American journal of nuclear medicine and molecular imaging 6(1): 94-101, 2016.

Thukkani Arun K, Shoghi Kooresh I, Zhou Dong, Xu Jinbin, Chu Wenhua, Novak Eric, Chen Delphine L, Gropler Robert J, Mach Robert H: PET imaging of in vivo caspase-3/7 activity following myocardial ischemia-reperfusion injury with the radiolabeled isatin sulfonamide analogue [(18)F]WC-4-116. American journal of nuclear medicine and molecular imaging 6(2): 110-9, 2016.

Makvandi Mehran, Tilahun Estifanos D, Lieberman Brian P, Anderson Redmond-Craig, Zeng Chenbo, Xu Kuiying, Hou Catherine, McDonald Elizabeth S, Pryma Daniel A, Mach Robert H: The sigma-2 receptor as a therapeutic target for drug delivery in triple negative breast cancer. Biochemical and biophysical research communications 467(4): 1070-5, Nov 2015.

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Last updated: 08/25/2016
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