Robert Babak Faryabi

faculty photo
Assistant Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
Room 553 BRB II/III, 421 Curie Boulevard
Philadelphia, PA 19104-6160
Philadelphia, PA 19104
Office: (215)573-8220
Education:
BSc (Electrical Engineering)
Sharif University of Technology, Tehran, Iran, 1995.
MSc (Electrical Engineering)
Sharif University of Technology, Tehran, Iran, 1997.
PhD (Computational Biology)
Texas A&M University, College Station, TX, 2009.
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Description of Itmat Expertise

Cancer Epigenetics
Computational Biology
Genomics
Machine Learning

Description of Research Expertise

We are a computational biology lab with focus on cancer epigenomics. Our research spans the areas of cancer biology, computational biology and machine learning. The overarching goal of our lab is to explore how oncogenic cell signaling pathways dysregulate enhancers' landscape of a tumor and understand their function in cancer.

The lab is specifically interested in lymphoma and leukemia which are the cancers of hematopoietic system. In addition to genetic alterations, abnormalities at epigenetic levels may give rise to these malignancies. We use genomics to identify the genetic variations in these tumor types and further elucidate how these genetic events alter a tumor's epigenome using population and single-cell epigenomics techniques.

As a member of Center for Personalized Diagnostics, we are also developing computational oncology frameworks to enrich clinical significance of diagnostic tumor genomics. Our goal is to advance the paradigm of personalized medicine by leveraging big data analytics to drive correlation between the a tumor genome and clinical covariates.

To learn more about our research interests and specifics of our projects check our lab's website

Selected Publications

Ryan RJH*, Petrovic J*, Rausch DM, Zhou Y, Lareau C, Kluk MJ, Christie AL, Lee W, Guo B, Donohue LKH, Gillespie S, Nardi V, Hochberg EP, Blacklow SC, Weinstock DM, Faryabi RB, Bernstein BE+, Aster JC+, Pear WS+: A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. Cell Reports 21(3): 784 - 797, October 2017.

Rolland DC, Basrur V, Jeon Y-K, McNeil-Schwalm C, Fermin D, Conlon K, Zhou Y, Ng SY, Tsou C-C, Brown NA, Thomas DG, Bailey NG, Omenn GS, Nesvizhskii AI, Root DE, Weinstock DM, Faryabi RB, Lim MS, Elenitoba-Johnson KSJ: Functional Proteogenomics Reveals Biomarkers and Therapeutic Targets in Lymphomas. Proceedings of the National Academy of Sciences 11(24): 6581-6586, May 2017.

Barlow JH*, Faryabi RB*, Callen E, Wong N, Malhowski A, Chen H-T, Gutierrez-Cruz G, Sun H-W, McKinnon P, Wright G, Casellas R, Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A : Identification of Early Replicating Fragile Sites that Contribute to Genome Instability. Cell 152(3): 620-32, January 2013 *co-first author.

Santos MA, Faryabi RB, Ergen AV, Day AM, Malhowski A, Canela A, Onozawa M, Lee J-E, Callen E, Gutierrez-Martinez P, Chen H-T, Wong N, Finkel N, Deshpande A, Sharrow S, Rossi DJ, Ito K, Ge K, Aplan PD, Armstrong SA, Nussenzweig A: DNA-damage-induced Differentiation of Leukaemic Cells as an Anti-cancer Barrier. Nature 514(7520): 107-11, October 2014.

Callen E, Faryabi RB, Luckey M, Hao B, Daniel JA, Yang W, Sun H-W, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park J-H, Nussenzweig A: The DNA Damage- and Transcription-associated Protein Paxip1 Controls Thymocyte Development and Emigration. Immunity 37(6): 971-85, December 2012.

Faryabi RB, Vahedi G, Datta A, Chamberland J-F, Dougherty ER: Recent Advances in the Control of Markovian Gene Regulatory Networks. Current Genomics 10(7): 540-547, November 2009.

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Last updated: 12/11/2017
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