John T. Seykora

faculty photo
Associate Professor of Dermatology
Member, Abramson Cancer Center, Hospital of the University of Pennsylvania
Department: Dermatology

Contact information
Department of Dermatology
421 Curie Blvd
Room 1011 BRB II/III
Philadelphia, PA 19104-6142
Office: 2158980170
Fax: 2155732143
Graduate Group Affiliations
Education:
B.A. (Biology with Honors)
University of Chicago, 1986.
M.S. (Biochemistry)
University of Chicago, 1986.
Ph.D. (Cell Biology)
Rockefeller University, 1992.
M.D. (Medicine)
Cornell University Medical College, 1993.
Permanent link
 

Description of Research Expertise

1. Keratinocyte growth and differentiation-mechanisms of growth control
2. Skin cancer-squamous cell carcinoma
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.

Description of Itmat Expertise

Cellular mechanisms that regulate keratinocyte growth.

In vivo models of skin cancer

Topical therapies for skin cancer

Selected Publications

Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett CM, Kallish S, Seykora JT, Liu F, Gaillard D, Katz JP, Kestner KH, Levin B, Mansfield C, Douglas JE, Cowart BJ, Tordoff M, Liu F, Zhu X, Barlow LA, Rubin AI, McGrath JA, Morrisey EE, Chu EY, Millar SE. : WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun. June 7, 2017; 8; 15397. doi: 10.1028/ncomms15397. PubMed PMID: 28589954; PubMed Central PMCID: PMCID: PMC5467248. June 2017.

Ma S, Imadojemu S, Beer K and Seykora JT. : Inflammatory features of frontal fibrosing alopecia. Journal of Cutaneous Pathology Epub: https://doi.org/10.1111/cup.12955 2017.

Ellebrecht, C.T., Bhoj, V.G., Nace, A., Choi, E.J., Mao, X, Cho, M.J.< Di Zenzo, G., Lanzavecchia, A., Seykora, J.T., Cotsarelis, G., Milone, M.C., Payne, A.S.: Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease. Science 353(6295): 179-84, July 2016 Notes: doi: 10.1126/science.aaf6756. Epub 2016 Jun 30.

Gui, J., Gober, M., yang, X, katlinski, K.V., Marshall, C.M., Sharma, M., Werth, V.P., Baker, D.P., Rui, H., Seykora, J.T., Fuchs, S.Y.: Therapeutic elimination of the type I interferon receptor for treating psoriatic sk inflammation. Journal of Investigative Dermatology, 2016 Jun 28 June 2016 Notes: pii: S0022-202X(16)32075-9. doi: 10.1016/j.jid.2016.06.608. (Epub ahead of print.

Oh, J.W., Kloepper, J., Langan, E.A., Kim, Y., Yeo, J., Kim, M.J.< Hsi, T.C., Rose, C., Yoon, G.S., Lee, S.J., Seykora, J.T., Kim, J.C., Sung, Y.K., Kim, M., Paus, R., Plikus, M.V.: A guide to studying human hair follicle cycling in vivo. Journal of Investigative Dermatology 36(1): 134-44, January 2016 Notes: Erratum in: J. Invest. Dermatol. 2016 Apr; 136(4):883.

Taylor, L.A., ODay, C., Dentchev, T., Hood, K., Chu, E.Y., Ridky, T.W., Seykora, J.T.: p15 expression differentiates nevus from melanoma. American Journal of Pathology In Press, 2016.

McNeal, A.S., Liu, K., Nakhate, V., Natale, C.A., Duperret, E.K., Capell, B.C., Dentchev, T., Berger, S.L., Herlyn, M., Seykora, J.T., Ridky, T.W.: CDKN2B loss promotes progression from benign melanocytic nevus to melanoma. Cancer Discov 5(10): 1072-85, October 2015 Notes: doi: 10.1158/2159-8290.CD-15-0196. Epub 2015 Jul 16.

Seykora, J.T., Dentchev, T., Margolis, D.: Fillagrin 2 barrier protein varies inversely with inflammation. Experimental Dermatology May 2015 Notes: May 8 doi:10.1111/exd.12749.

Ortiz, M.L., Kumar V., Martner, A., Mony S., Donthireddy, L., Condamine, T., Seykora, J., Knight, S.C., Malietzis, G., Lee, G.H., Moorghen, M., Lenox, B., Luetteke, N., Celis, E., Gabrilovich, D.: Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells. Journal of Experimental Medicine 2015 Mar 9 212(3): 351-67, March 2015 Notes: doi: 10.1084/jem.20140835. Epub 2015 Feb 9.

Sanzari, J.K., Diffendender, E.S., Hagan, S., Billings, P.C., Gridley, D.S., Seykora, J.T., Kennedy, A.R., Cengel, K.A.: Dermatopathology effects of simulated solar particle event radiation exposure in the porcine model. Life Sciences in Space Research 6: 21-28, 2015.

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Last updated: 09/12/2017
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