John T. Seykora

faculty photo
Associate Professor of Dermatology
Department: Dermatology

Contact information
Room 1011 BRB II/III
421 Curie Blvd
6142
Philadelphia, PA 19104
Office: 2158980170
Fax: 2155732143
Graduate Group Affiliations
Education:
M.S. (Biochemistry)
University of Chicago, 1986.
B.A. (Biology with Honors)
University of Chicago, 1986.
Ph.D. (Cell Biology)
Rockefeller University, 1992.
M.D. (Medicine)
Cornell University Medical College, 1993.
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Description of Research Expertise

1. Keratinocyte growth and differentiation-mechanisms of growth control
2. Skin cancer-squamous cell carcinoma
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.

Description of Itmat Expertise

Cellular mechanisms that regulate keratinocyte growth.

In vivo models of skin cancer

Topical therapies for skin cancer

Selected Publications

Billings, PC, Sanzari, JK, Kennedy, AR, Cengel, KA and Seykora, JT: Quantitation of skin pigmentation using open source image analysis software. Pending revisions Experimental Dermatology 2014.

Wong, WJ, Richardson, T, Seykora, JT, Cotsarelis, G and Simon, MC: Hypoxia inducible factors regulate filaggrin expression and epidermal barrier function. Pending revisions, JID 2014.

Gober MD, Bashir HM, Seykora JT: Reconstructing skin cancers using animal models. Cancer Metastasis Rev. 32: 123-128, 2013

Sanzari, JK, Billings, PC, Diffenderfer, ES, Gridley, DS, Seykora, JT, Kennedy, AR and Cengel, KA: Acute Biological Effects of Solar Particle Radiation on Skin Using a Porcine Model. Radiat Res. Feb 2013.

Kouno M, Lin C, Schechter N, Siegel D, Yang X, Seykora JT, and Stanley, J : Targeted delivery of tumor necrosis factor-related apoptosis-inducing ligand to keratinocytes with a pemphigus monoclonal antibody. J Invest Dermatol 133: 2212-20 2013.

Chehoud, C., Rafail, S., Tyldsley, A., Seykora, J., Lambris, J. and Grice, E. : Complement modulates the cutaneous microbiome and inflammatory milieu. PNAS 110: 15061-6, 2013.

Ratushny, V., Gober, M., Hick, R., Ridky, T., and Seykora, J.: “From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma.” J Clin Invest. 122(2): 464–472, 2012.

Teta, M., Choi, YS, Okegbe, T., Wong, G., Tam, O., Chong, M., Seykora, J., Nagy, A., Littman, D., Andl, T., and Millar, S.: “Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin.” Development 139: 1405-16, 2012.

Wanat KA, Holler PD, Dentchev T, Simbirl K, Robertson E, Seykora JT, Rosenbach M: Viral-Associated Trichodysplasia: characterization of a novel polyoma virus infection with therapeutic insights. Archives of Dermatology 148: 219-23, 2012.

Chu, E Y, Wanat, K A, Miller, C J, Amaravadi, R K, Fecher, L A, Brose, M S, McGettigan, S, Giles, L R, Schuchter, L M, Seykora, J T, Rosenbach, M: Diverse cutaneous side effects associated with BRAF inhibitor therapy: A clinicopathologic study. J Am Acad Dermatol 67: 1265-72 2012.

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Last updated: 07/24/2014
The Trustees of the University of Pennsylvania