Mei-Lun Wang

faculty photo
Adjunct Assistant Professor of Pediatrics
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
34th Street and Civic Center Boulevard
902-E Abramson Research Building
Philadelphia, PA 19104
Office: 267-426-7223
Fax: 267-426-7814
Education:
BA (Interdisciplinary Studies)
Cornell University, 1991.
MD (Medicine)
University of Pennsylvania School of Medicine, 1995.
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Description of Itmat Expertise

My laboratory is interested in the mechanisms by which esophageal epithelial cells act as innate immune effector cells in the context of GERD and eosinophilic esophagitis.

Selected Publications

Muir AB, Lim DM, Benitez AJ, Chandramouleeswaran PM, Lee AJ, Ruchelli ED, Spergel JM, and Wang ML.: Esophageal Epithelial-Mesenchymal Cross-Talk Leads to Features of Epithelial to Mesenchymal Transition In Vitro. Experimental Cell Research 319(6): 850-9, Apr 2013 Notes: *Featured article in Global Medical Discovery [ISSN 1929-8536] October, 2013.

Jyonouchi S, Smith C, Saretta F, Abraham V, Ruymann K, Modayur PC, Wang ML, Spergel JM, and Cianferoni A.: Invariant Natural Killer T Cells in Children with Eosinophilic Esophagitis. Clinical Exp Allergy In press 2013.

Siracusa MD, Saenz SA, Tait Wojno ED, Kim BS, Osborne LC, Ziegler C, Benitez AJ, Ruymann KR, Farber DL, Sleiman PM, Hakonarson H, Cianferoni A, Wang ML, Spergel JM, Comeau MR, and Artis D: TSLP-mediated extramedullary hematopoiesis promotes allergic inflammation. Immunity In press, In press 2013.

Noti M, Tait-Wojno ED, Kim BS, Siracusa MC, Giacomin PR, Nair MG, Benitez AJ, Ruymann KR, Muir AB, Hill DA, Chikwava KR, Moghaddam AE, Sattentau QJ, Alex A, Zhou C, Yearley JH, Menard-Katcher P, Kubo M, Obata-Ninomiya K, Karasuyama H, Comeau MR, Brown-Whitehorn T, de Waal Malefyt R, Sleiman, PM, Hakonarson H, Cianferoni A, Falk GW, Wang ML, Spergel JM, and Artis D.: TSLP-Elicited Basophil Responses Can Mediate the Pathogenesis of Eosinophilic Esophagitis. Nature Medicine 19(8): 1005-13, 2013.

Spergel JM, Brown-Whitehorn TF, Cianferoni A, Shuker M, Wang ML, Verma R, and Liacouras CA: Identification of Causative Foods in Children with Eosinophilic Esophagitis Treated with an Elimination Diet. Journal of Allergy and Clinical Immunology 130(2): 461-7, August 2012.

Lim DM and Wang ML: Toll-Like Receptor 3 Signaling Enables Human Esophageal Epithelial Cells to Sense Endogenous Danger Signals Released by Necrotic Cells. American Journal of Physiology: Gastrointestinal & Liver Physiology 301(1): G91-9, July 2011.

Tetreault MP, Wang ML, Yang Y, Travis J, Yu QC, Klein-Szanto AJ, and Katz JP.: Klf4 Overexpression Activates Epithelial Cytokines and Inflammation-Mediated Esophageal Squamous Cell Cancer in Mice. Gastroenterology 139(6): 2124-2134, December 2010.

Lim DM, Narasimhan S, Michaylira CZ, and Wang ML: TLR3-Mediated NF-kB Signaling in Human Esophageal Epithelial Cells. American Journal of Physiology: Gastrointestinal and Liver Physiology. 297: G1172-1180, December 2009.

Wang ML, Keilbaugh SA, Cash-Mason T, He XC, Li L, and Wu GD.: Immune-Mediated Signaling in Intestinal Goblet Cells via PI3-Kinase and AKT-Dependent Pathways. American Journal of Physiology: Gastrointestinal and Liver Physiology. 295(G1122-G1130), October 2008.

Barnes SL, Vidrich A, Wang ML, Wu GD, Cominelli F, Rivera-Nieves J, Bamias G, and Cohn SM.: Resistin-Like Molecule Beta (RELMĪ²/FIZZ2) is Highly Expressed in the Ileum of SAMP1/YitFc Mice and is Associated with Initiation of Ileitis. Journal of Immunology 179(10): 7012-20, November 2007.

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Last updated: 11/14/2014
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