My current research interests are in the translation of various gene transfer technologies into large animal models, up to and including non-human primates.
From a clinical standpoint, I am interested in gastrointestinal surgical problems. In particular, my interests in complex pancreatic, liver and biliary tract disease mesh well with the mission of the University of Pennsylvania Medical center as a quaternary referral center.
The renaissance of interest in surgical procedures for the treatment of morbid obesity has created an opportunity for me to assist in the management of these complex patients. A second application is in the use of partial ileal bypass for the treatment of hypercholesterolemia. In both cases, surgery has proven capable of improving the metabolism of affected patients.
The proliferation of bariatric surgery has also spawned a group of people who have not done well with their surgery, often for obscure reasons. I have developed expertise in evaluation and management with revisional surgery in such patients.
McCullough BA, Yudkoff M, Batshaw ML, Wilson JM, Raper SE, Tuchman M: Genotype spectrum of ornithine transcarbamylase deficiency: correlation with the clinical and biochemical phenotype. American Journal of Medical Genetics 93(4): 313-9, Aug 14 2000.
Chirmule N, Raper SE, Burkly L, Thomas D, Tazelaar J, Hughes JV, Wilson JM: Readministration of adenoviral vector in non-human primate lungs by blockade of CD-40-CD40L interactions.
Journal of Virology 74: 3345-3352, Apr 2000.
Raper SE: Acute pancreatitis secondary to dehydration: Case report and review of the literature.
American Surgeon 65(11): 1084-1087, Nov 1999.
Nunes, FA, Furth EE, Wilson JM, Raper, SE: Gene transfer into the liver of non-human primates with E1-deleted recombinant adenoviral vectors: Safety of readministration.
Human Gene Therapy 10(15): 2515-2526, Oct 10 1999.
Burke CV, Buettger CW, Davis EA, McClane SJ, Matschinsky FM, Raper SE: Cell biological assessment of human glucokinase mutants causing maturity onset diabetes of the young type 2 (MODY-2) or glucokinase-linked hyperinsulinemia. Biochemical Journal 342(Pt 2): 345-352, Sept 1 1999.
Chirmule N, Truneh A, Haecker SE, Tazelaar J, Gao G-P, Raper SE, Hughes JV, Wilson JM: Repeated administration of adenoviral vectors in lungs of human CD4 transgenic mice treated with a non-depleting CD4 antibody. Journal of Immunology 163(1): 448-55, Jul 1 1999.
DeMatteo RP, Yeh H, Friscia M, Capparelli D, Burke CV, Desai N, Chu G, Markmann JF, Raper SE, Barker CF: Cellular immunity delimits adenoviral gene therapy strategies for the treatment of neoplastic diseases. Annals of Surgical Oncology 6(1): 88-94, Jan-Feb 1999.
Hashimoto M, Kothary P, Raper SE: Phenobarbital in comparison with carbon tetrachloride and phenobarbital induced cirrhosis in rat liver regeneration.
Journal of Surgical Research 81(2): 164-169, Feb 1998.
Hashimoto M, Kothary P, Raper SE.: Treatment of cirrhotic rats with epidermal growth factor and insulin accelerates liver DNA synthesis after partial hepatectomy.
Journal of Gastroenterology & Hepatology 13(12): 1259-1265, Dec 1998.
Ye X, Gao G-P, Pabin C, Raper SE, Wilson JM.: Evaluating the Potential of Germline Transmission after Intravenous Administration of Recombinant Adenovirus in the C3H Mouse.
Human Gene Therapy 9(14): 2135-2142, Sept 1998.
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Last updated: 05/21/2009
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