Diva D. De León, M.D. is an Assistant Professor of Pediatrics and a Pediatric Endocrinologist in the Division of Endocrinology and Diabetes at The Children's Hospital of Philadelphia. Dr. De León research interest focuses on congenital and acquired forms of hyperinsulinemic hypoglycemia. She is particularly interested in the role that alterations of the entero-insular axis may play in the pathophysiology of these disorders.
Dr. De León specializes in the diagnosis and management of monogenic disorders of insulin regulation resulting in diabetes and hypoglycemia, and general endocrinologic problems. Dr. De León predominantly cares for children with congenital and acquired forms of hyperinsulinemic hypoglycemia.
Selected Publications
Browning E, Wang H, Hong N, Yu K, Buerk DG, DeBolt K, Gonder D, Sorokina EM, Patel P, De León DD, Feinstein SI, Fisher AB and Chatterjee S: Mechanotransduction drives post ischemic revascularization through KATP channel closure and production of reactive oxygen species. Antioxidants & Redox Signaling Epub 2013 June 12 2013.
Calabria AC, Gallagher PR, Stanley CA, De León DD: The GLP-1 receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital hyperinsulinism due to inactivating mutations in the ATP-sensitive potassium channel. Diabetes 61(10): 2585-91, Oct [Epub 2012 Aug 1] 2012.
Stanescu DE, Hughes N, Kaplan B, Stanley CA, De León DD: Novel presentations of congenital hyperinsulinism due to mutations in the MODY genes: HNF1A and HNF4A. J Clin Endocrinol Metab 97(10): E2026-30, Oct [Epub 2012 Ju 16] 2012.
Lin YW, Akrouh A, Hsu YC, Hughes N, Nichols CG, De León DD: Compound heterozygous mutations int eh SUR1 (ABCC 8) subunit of pancreatic KATP channels causes neonatal diabetes by perturbing the coupling between Kir6.2 and SUR1 subunits. Channels 6(2): 133-8, March/April 2012.
Calabria AC, Gallagher PR, Simmons R, Blinman T, De León DD: Postoperative surveillance and detection of postprandial hypoglycemia after fundoplasty in children. J Pediatr 159(4): 597-601, October 2011.
Pinney SE, Oliver-Krasinski J, Ernst L, Hughes N, Patel P, Stoffers DA, Russo P, De León DD: Neonatal diabetes and congenital malabsorptive diarrhea attributable to a novel mutation in the human neurogenin-3 gene coding sequence. J Clin Endocrinol Metab 96(7): 1960-5, July 2011.
Soleimanpour SA, Crutchlow MF, Ferrari AM, Raum JC, Groff DN, Rankin MM, Liu C, De León DD, Naji A, Kushner JA, and Stoffers DA
: Calcineurin signaling regulates human islet β-cell survival J Biol Chem 285(51): 40050-9, Dec [Epub 2010 Oct 13] 2010.
Palladino AA, Sayed S, Katz LE, Gallagher PR, De León DD: Increased glucagon-like peptide-1 secretion and post-prandial hypoglycemia in children after Nissen fundoplication. J Clin Endocrinol Metab 94(1): 39-44, Jan 2009.
De León DD, Li C, Delson MI, Matschinsky FM, Stanley CA, Stoffers DA: Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion. J Biol Chem 283(38): 25786-93, Sep [Epub 2008 Jul 17] 2008.
Hoffman TL, Blanco E, Lane A, Galvin-Parton P, Gadi I, Santer R, De León D, Stanley C, Wilson TA.
: Glucose metabolism and insulin secretion in a patient with ABCC8 mutation and Fanconi-Bickel syndrome caused by maternal isodisomy of chromosome 3. Clin Genet 71(6): 551-7, June 2007.
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Last updated: 07/13/2013
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