Research Interests: HLA genes and molecules in clinical transplantation
Keywords: Human immunogenetics, HLA genes and molecules. Clinical Histocompatibility, clinical transplantation, autoimmunity.
Research Summary:
Dr. Kamoun's research interest is to define the extent and nature of HLA Haplotype genetic diversity and to understand the biological relevance of amino acid polymorphism in HLA class I and class II molecules. Computational and biostatical methods are used to evaluate the significance of HLA amino acid polymorphism in clinical transplantation and autoimmunity.
Another interest is to better understand the impact of B cell alloresponse and anti-HLA antibodies on allograft outcomes in clinical transplantation including islet cell transplantation. Clinical trials are used to assess the effectiveness of B cell depleting agents on alloantibody levels and allograft survival in transplant recipients.
Clinical laboratory immunology: Diagnostic tests used in the evaluation of autoimmune diseases, infectious diseases, and immune deficiencies.
Clinical histocompatibility testing: HLA genotyping and HLA antibody testing used for the evaluation of solid organ and allogeneic bone marrow/hematopoietic cell transplantion and donor selection.
Selected Publications
Kamoun Malek, Holmes John H, Israni Ajay K, Kearns Jane D, Teal Valerie, Yang Wei Peter, Rosas Sylvia E, Joffe Marshall M, Li Hongzhe, Feldman Harold I: HLA-A amino acid polymorphism and delayed kidney allograft function. Proceedings of the National Academy of Sciences of the United States of America 105(48): 18883-8, Dec 2008.
Nikaein Afzal, Cherikh Wida, Nelson Karen, Baker Timothy, Leffell Sue, Bow Laurine, Crowe Debbie, Connick Ketra, Head Mary Ann, Kamoun Malek, Kimball Pam, Klohe Ellen, Noreen Harriet, Rebellato Lorita, Sell Tom, Sullivan Karen, Land Geoffrey: Organ procurement and transplantation network/united network for organ sharing histocompatibility committee collaborative study to evaluate prediction of crossmatch results in highly sensitized patients. Transplantation 87(4): 557-62, Feb 2009.
Harris, Rebecca A. Sugimoto, Kazushi. Kaplan, David E. Ikeda, Fusao. Kamoun, Malek. Chang, Kyong-Mi.: Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans. Hepatology 48(1): 70-9, Jul 2008.
Sutter, Jennifer A. Kwan-Morley, Jennifer. Dunham, Jon. Du, Yang-Zhu. Kamoun, Malek. Albert, Daniel. Eisenberg, Robert A. Luning Prak, Eline T.: A longitudinal analysis of SLE patients treated with rituximab (anti-CD20): factors associated with B lymphocyte recovery. Clin Immunol 126(3): 282-90, Mar 2008.
Goral S, Prak EL, Kearns J, Bloom RD, Pierce E, Doyle A, Grossman R, Naji A, Kamoun M: Preformed donor-directed anti-HLA-DP antibodies may be an impediment to successful kidney transplantation. Nephrol Dial Transplant 23(1): 390-2, Jan 2008.
Kamoun, M. Israni, A K. Joffe, M M. Hoy, T. Kearns, J. Mange, K C. Feldman, D. Goodman, N. Rosas, S E. Abrams, J D. Brayman, K L. Feldman, H I.: Assessment of differences in HLA-A, -B, and -DRB1 allele mismatches among African-American and non-African-American recipients of deceased kidney transplants. Transplant Proc 39(1): 55-63, Jan-Feb 2007.
Rickels, Michael R. Kamoun, Malek. Kearns, Jane. Markmann, James F. Naji, Ali.: Evidence for allograft rejection in an islet transplant recipient and effect on beta-cell secretory capacity. J Clin Endocrinol Metab 92(7): 2410-4, Jul 2007.
Monos, Dimitri. Heliopoulos, John. Argyris, Elias. Cordopatis, Paul. Zompra, Aikaterini. Kamoun, Malek.: Analysis of the CD2 and spliceosomal Sm B/B' polyproline-arginine motifs defined by a monoclonal antibody using a phage-displayed random peptide library. J Mol Recognit 19(6): 535-41, Nov-Dec 2006.
Narula S, LaRosa DF, Kamoun M, Dalmau J, Levinson AI: Progressive multifocal leukoencephalopathy in a patient with common variable immunodeficiency and abnormal CD8+ T-cell subset distribution. Ann Allergy Asthma Immunol 98(5): 483-9, May 2007.
Luning Prak ET, Young DS, Kamoun M, Nachamkin I, Alexander CB, Spitalnik SL, Peerschke EI, Smith BR: 2008 ACLPS panel discussion on resident education in clinical pathology. Am J Clin Pathol 131(5): 618-22, May 2009.
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Last updated: 07/19/2013
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