Pancreatic Cancer, Notch, Hippo, Liver Development, Pancreatic Development, Organogenesis
Description of Research
Stem/Progenitor Cells in Development and Disease
How do internal organs achieve their remarkable structures? What determines the size of organs? How are stem cells regulated in adult solid organs? What cells give rise to cancer? During mammalian organogenesis, stem/progenitor cells and their derivatives undergo carefully controlled division, differentiation, and morphogenesis to generate complex functioning three-dimensional structures. Our laboratory uses the tools of developmental biology to address problems relevant to development, regenerative medicine and cancer. In particular, we use the mouse as a model system to genetically tag specific cellular lineages or to alter the function of important signaling pathways. The focus is on stem cells and progenitor cells in the vertebrate liver and pancreas, essential organs with great clinical importance and a rich history in developmental biology. Our long-term goal is to understand in detail how these different cell types behave during development, organ regeneration, and carcinogenesis. We hope to exploit insights gained from these studies to develop new approaches to cancer therapy and bioengineering.
Rotation projects may be available based upon applicant interest. Please contact Dr. Stanger directly to discuss potential projects.
Ben Stanger, MD, PhD – Principal Instigator
Nicole Aiello - Graduate Student
Erin Dekleva - Research Specialist
Yi-Ju Chen, PhD - Post-Doctoral Researcher
Ravi Maddipatti, MD - Research Associate
Alfredo Penzo, PhD - Post-Doctoral Researcher
Zhewei Shen - Graduate Student
Chenghua Yang - Research Specialist, Lab Manager
Kilang Yanger - Graduate student
David Balli - Postdoctoral Researcher
Neha Bhagwat - Postdoctoral Researcher
Yanger K, Zong Y, Maggs L, Shapira SN, Maddipati R, Aiello NM, Thung SN, Wells RG, Greenbaum L, and Stanger BZ: Robust cellular reprogramming occurs spontaneously during liver regeneration. Genes Dev 27(7): 719-24, 2013
Gao T, Zhou D, Yang C, Singh T, Penzo-Mendez A, Maddipati R, Tzatsos A, Bardeesy N, Avruch J, Stanger BZ: Hippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas. Gastroenterology 144(7): 1543-1553, 2013
Stanger BZ, Hebrok M: Control of cell identity in pancreas development and regeneration. Gastroenterology 144(6): 1170-9, 2013.
Yi C*, Shen Z, Stemmer-Rachamimov A, Dawany N, Troutman S, Showe LC, Liu Q, Shimono A, Sudol M, Holmgren L, Stanger BZ*, Kissil JL*: The p130 Isoform of Angiomotin Is Required for Yap-Mediated Hepatic Epithelial Cell Proliferation and Tumorigenesis. Sci Signaling 6(291): ra77, 2013 Notes: *Co-corresponding authors.
Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McCallister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH, Leach SD, Stanger BZ: EMT and dissemination precede pancreatic tumor formation. Cell 148(1-2): 349-61, 2012.
Zong Y, Panikkar A, Xu J, Antoniou A, Raynaud P, Lemaigre F, Stanger BZ: Notch signaling controls liver development by regulating biliary differentiation. Development 136(10): 1727-39, 2009.
Stanger BZ*, Tanaka AJ, Melton DA*: Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature 445(7130): 886-91, 2007 Notes: *Co-corresponding authors.
back to top
Last updated: 03/06/2014
The Trustees of the University of Pennsylvania