faculty photo

Jane Marie Vanderkooi

Emeritus Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics

Contact information
909C Stellar-Chance Laboratories
University of Pennsylvania
School of Medicine
Philadelphia, PA 19104
Office: (215) 898-8783
Fax: (215) 573-2042
Education:
B.A. (Chemistry)
Central College, Pella, IA, 1967.
Ph.D. (Biochemistry)
St. Louis University, 1971.
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Description of Research Expertise

Hydration of proteins and macromolecules.

Stability of proteins and peptides in sugar (trehalose) matrices

Photoreactions of tryptophan and porphyrins.

Techniques: fluorescence, phosphorescence, infrared, protein isolation

Selected Publications

Dalosto, S.D., Vanderkooi, J. M., Sharp, K. A. : Vibrational Stark effects on carbonyl, nitrile and nitrosyl compounds including heme ligands, CO, CN and NO studied with density functional theory. J. Phys. Chem. 108: 6450-57, 2004.

Zelent, B., Kaposi, A. D., Nucci, N. V., Sharp, K. A., Dalosto, S. D., Wright, W. W., Vanderkooi, J. M.: Water channel of horseradish peroxidase studied by the charge-transfer absorption band of ferric heme. J. Phys. Chem. B. (Festschrift in honor of Gerald Small), 2004.

Pontratov, V.V., Friedrich, J. Marlovic, D., Scheer, H., Vanderkooi, J. M. : Spectral diffusion experiment with a denatured protein. J. Phys. Chem. B. 108: 1109-14, 2004.

Lesch, H., Schlichter, J., Friedrich, J., Vanderkooi, J. M.: Molecular Probes: What is the range of their interaction with the environment? Biophys. J. 86: 467-72, 2004.

Quantum calculations of heme proteins. Biophysical Society. February 2003 Notes: San Antonio Texas (S. Dalosto presenter).

Kaposi, A. D., Prabhu, N. V., Dalosto, S. D., Sharp, K. A., Wright, W. W., Stavrov, S. S., Vanderkooi, J. M. : Solvent dependent and independent motions of CO-horseradish peroxidase examined by infrared spectroscopy and molecular dynamics calculations. Biophys. Chem. 106: 1-14, 2003.

Kaposi AD., Wright WW., Fidy J., Stavrov SS., Vanderkooi JM., Rasnik I.: Carbonmonoxy horseradish peroxidase as a function of pH and substrate: influence of local electric fields on the optical and infrared spectra. Biochemistry 40(12): 3483-91, Mar 27 2001.

Argyris EG., Vanderkooi JM., Paterson Y.: Mutagenesis of key residues identifies the connection subdomain of HIV-1 reverse transcriptase as the site of inhibition by heme. European Journal of Biochemistry 268(4): 925-31, Feb 2001.

Rasnik, I, Sharp, K., Fee, J. A. & Vanderkooi, J. M: Spectral analysis of cytochrome c: Effect of heme conformation, axial ligand, peripheral substituents and local electric fields. J. Phys. Chem. B 105: 282-286, 2001.

Sharp, K., Mandan, B., Manas, E. S., & Vanderkooi, J. M: Water structure changes induced by hydrophobic and polar solutes revealed by simulations and IR spectroscopy. J. Chem. Phys 114: 1791-1796, 2001.

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Last updated: 11/12/2007
The Trustees of the University of Pennsylvania