My laboratory uses the tools of clinical investigation and applied genomics to reveal mechanisms of human heart failure. This has included establishing a multicenter cohort study of advanced heart failure (Penn Heart Failure Study; PHFS) and a multicenter consortium for human myocardial transcriptomics and eQTL mapping (Myocardial Applied Genomics Network; MAGNet). Notable discoveries include the first demonstration that peripheral blood gene expression provides a clinical biomarker to track cardiac allograft rejection, identification of abnormalities in forkhead signaling and neuregulin signaling in common forms of human heart failure, and discovery of the 1p36 HSPB7/CLCNKA locus as the first bonafide genetic risk factor for non-familial heart failure.
Selected Publications
Ky B, French BC, Levy WC, Sweitzer NK, Fang JC, Wu AHB, Goldberg LR, Jessup M, Cappola TP: Multiple biomarkers for risk prediction in chronic heart failure. Circ Heart Fail 5(2): 183-90, Mar 2012.
Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A, Castillo BA, Li YR, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight BF, Balasubramanyam A, Barnard J, Bauer F, Baumert J, Bhangale T, Böhm BO, Braund PS, Burton PR, Chandrupatla HR, Clarke R, Cooper-Dehoff RM, Crook ED, Davey-Smith G, Day IN, de Boer A, de Groot MC, Drenos F, Ferguson J, Fox CS, Furlong CE, Gibson Q, Gieger C, Gilhuijs-Pederson LA, Glessner JT, Goel A, Gong Y, Grant SF, Grobbee DE, Hastie C, Humphries SE, Kim CE, Kivimaki M, Kleber M, Meisinger C, Kumari M, Langaee TY, Lawlor DA, Li M, Lobmeyer MT, Maitland-van der Zee AH, Meijs MF, Molony CM, Morrow DA, Murugesan G, Musani SK, Nelson CP, Newhouse SJ, O'Connell JR, Padmanabhan S, Palmen J, Patel SR, Pepine CJ, Pettinger M, Price TS, Rafelt S, Ranchalis J, Rasheed A, Rosenthal E, Ruczinski I, Shah S, Shen H, Silbernagel G, Smith EN, Spijkerman AW, Stanton A, Steffes MW, Thorand B, Trip M, van der Harst P, van der A DL, van Iperen EP, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Wolffenbuttel BH, Young T, Zafarmand MH, Zmuda JM; the Look AHEAD Research Group; DIAGRAM consortium, Boehnke M, Altshuler D, McCarthy M, Kao WH, Pankow JS, Cappola TP, Caulfield M, Dominiczak A, Shields DC, Bhatt D, Zhang L, Curtis SP, Danesh J, Casas JP, van der Schouw YT, Onland-Moret NC, Doevendans PA, Dorn GW 2nd, Farrall M, Fitzgerald GA, Hamsten A, Hegele R, Hingorani AD, Hofker MH, Huggins GS, Illig T, Jarvik GP, Johnson JA, Klungel OH, Knowler WC, Koenig W, März W, Meigs JB, Melander O, Munroe PB, Mitchell BD, Bielinski SJ, Rader DJ, Reilly MP, Rich SS, Rotter JI, Saleheen D, Samani NJ, Schadt EE, Shuldiner AR, Silverstein R, Kottke-Marchant K, Talmud PJ, Watkins H, Asselbergs F, de Bakker PI, McCaffery J, Wijmenga C, Sabatine MS, Wilson JG, Reiner A, Bowden DW, Hakonarson H, Siscovick DS, Keating BJ.: Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet 90(3): 410-25, Mar 2012.
French BC, Lumley T, Cappola TP, and Mitra N: Non-iterative, regression-based estimation of haplotype associations with censored survival outcomes. Stat Appl Genet Mol Biol 11(3): 4, Feb 2012.
Shan X, Quaile MP, Monk JK, French BC, Cappola TP, Margulies KB: Differential expression of PDE5 in failing and nonfailing human myocardium. Circ Heart Fail 5(1): 79-86, Jan 2012.
Testani JM, McCauley BD, Chen J, Coca SG, Cappola TP, Kimmel SE: Clinical characteristics and outcomes of patients with improvement in renal function during the treatment of decompensated heart failure. J Card Fail 17(12): 993-1000, Dec 2011.
Testani JM, Coca SG, Shannon RP, Kimmel SE, Cappola TP: Influence of renal dysfunction phenotype on mortality in the setting of cardiac dysfunction: analysis of three randomized controlled trials. Eur J Heart Fail 13(11): 1224-30, Nov 2011.
Barth AS, Kumordzie A, Frangakis C, Margulies KB, Cappola TP, Tomaselli GF: Reciprocal transcriptional regulation of metabolic and signaling pathways correlates with disease severity in heart failure. Circ Cardiovasc Genet 4(5): 475-83, Oct 2011.
Jessup M, Greenberg B, Mancini D, Cappola TP, Pauly DF, Jaski B, Alex Yaroshinsky A, Zsebo KM, Dittrich H, Hajjar RJ: CUPID - a phase 2 trial of intracoronary gene therapy of sarcoplasmic
reticulum Ca2+ ATPase (SERCA2a) in patients with advanced heart failure. Circulation 124(3): 304-313, July 2011.
Ky B, French B, Ruparel K, Sweitzer NK, Fang JC, Levy WC, Sawyer DB, Cappola TP: The vascular marker soluble fms-like tyrosine kinase 1 is associated with disease severity and adverse outcomes in chronic heart failure. J Am Coll Cardiol 58(4): 395-401, July 2011.
Testani J, Cappola TP, Brensinger C, Shannon RP, Kimmel S: Interaction between loop-diuretic associated mortality and blood urea nitrogen concentration in chronic heart failure. J Am Coll Cardiol 58(4): 375-382, July 2011.
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Last updated: 07/31/2012
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