Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.
Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).
Shackleford, J., Soans, R.E., Lim, D.C., Keenan, B.T. and Pack, A.I.: Automated protein localization of blood brain barrier vasculature in brightfield IHC images. PLOS ONE 2016 Notes: in press.
Perron, I.J., Pack, A.I. and Veasey, S.: Diet/energy balance affect wakefulness independent of body weight. Sleep 38(12): 1893-1903, Dec 2015.
Bjornsdottir, E., Keenan, B.T., Eysteinsdottir, B., Arnardottir, E.S., Janson, C., Gislason, T., Sigurdsson, J.F., Kuna, S.T., Pack, A.I. and Benediktsdottir, B.: Quality of life among untreated sleep apnea patients compared with the general population and changes after treatment with positive airway pressure. Journal of Sleep Research 24(3): 328-338, Jun 2015.
Li, Q.Y., Berry, R.B., Goetting, M.G., Staley, B., Soto-Calderon, H., Tsai, S.C., Jasko, J.G., Pack, A.I. and Kuna, S.T.: Detection of upper airway status and respiratory events by a current generation positive airway pressure device. Sleep 38(4): 597-605, Apr 2015.
Pak, V.M., Keenan, B.T., Jackson, N., Grandner, M.A., Maislin, G., Teff, K., Schwab, R.J., Arnardottir, E.S., Juliusson, S., Benediktsdottir, B., Gislason, T. and Pack, A.I.: Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. International Journal of Obesity (London) 39(3): 472-479, 2015.
Bjornsdottir, E., Benediktsdottir, B., Pack, A.I., Arnardottir, E.S., Kuna, S.T., Gislason, T., Keenan, B.T., Maislin, G. and Sigurdsson, J.F.: The prevalence of depression among untreated obstructive sleep apnea patients using a standardized psychiatric interview. Journal of Clinical Sleep Medicine 2015 Notes: Aug 31. pii: jc-00475-14. [Epub ahead of print]
Azarbarzin, A., Ostrowski, M., Younes, M., Keenan, B.T., Pack, A.I., Staley, B. and Kuna, S.T.: Arousal responses during overnight polysomnography and their reproducibility in healthy young adults. Sleep 38(8): 1313-1321, 2015.
Lim, D.C., Brady, D.C., Po, P., Chuang, L.P., Marcondes, L., Kim, E.Y., Keenan, B.T., Guo, X., Maislin, G., Galante, R.J. and Pack. A.I.: Simulating obstructive sleep apnea patients’ oxygenation characteristics into a mouse model of cyclical intermittent hypoxia. Journal of Applied Physiology 118(5): 544-557, 2015.
Arnardottir, E.S., Lim, D.C., Keenan, B.T., Maislin, G., Benediktsdottir, B., Juliusson, S., Pack, A.I. and Gislason, T.: Effects of obesity on the association between long-term sleep apnea treatment and changes in interleukin-6 levels: the Icelandic Sleep Apnea Cohort. Journal of Sleep Research 24(2): 148-159, 2015.
Magalang, U.J., Arnardottir, E.S., Chen, N.H., Cistulli, P.A., Gislason, T., Lim, D., Penzel, T., Schwab, R., Tufik, S. and Pack, A.I.: Agreement in the scoring of respiratory events among international sleep centers for home sleep testing. Journal of Clinical Sleep Medicine 2015 Notes: Aug 21. pii: jc-00179-15. [Epub ahead of print]
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Last updated: 01/22/2016
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