General adult psychiatry and psychopharmacology
Evaluation and management of treatment-resistant mood and anxiety disorders
Emergency psychiatry
Vagus nerve stimulation for treatment-resistant mood disorders
Endocrine and metabolic aspects of mood and anxiety disorders
Stress neurobiology
Biomarkers of stress, allostatic load, innate immune function, and metabolic syndrome
Clinical trials of psychopharmacologic agents in psychiatric disorders
Clinical trials of vagus nerve stimulation in psychiatric disorders
Endocrine challenge tests
Analysis of pulsatile hormone secretion
Circadian rhythm analysis
Continuous cerebrospinal fluid sampling in human subjects
Arterial puncture and catheterization in human subjects
Catecholamine kinetics in arterial and venous blood
Psychometric assessment of mood and anxiety states
Selected Publications
Grillon, C., Heller, R., Hirschhorn, E., Kling, M. A., Pine, D. S., Schulkin, J., Vythilingam, M.: Acute hydrocortisone treatment increases anxiety but not fear in healthy volunteers: a fear-potentiated startle study. Biol Psychiatry 69(6): 549-55, 2010.
Regenold, W. T., Phatak, P., Marano, C. M., Sassan, A., Conley, R. R., Kling, M. A.: Elevated cerebrospinal fluid lactate concentrations in patients with bipolar disorder and schizophrenia: implications for the mitochondrial dysfunction hypothesis. Biol Psychiatry 65(6): 489-94, 2009.
Kling, M. A., Coleman, V. H., Schulkin, J.: Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus? Depress Anxiety 26(7): 641-9, 2009.
Abbott, A. N., Guidry, T. V., Welsh, K. J., Thomas, A. M., Kling, M. A., Hunter, R. L., Actor, J. K.: 11beta-hydroxysteroid dehydrogenases are regulated during the pulmonary granulomatous response to the mycobacterial glycolipid trehalose-6,6''-dimycolate. Neuroimmunomodulation 16(3): 147-54, 2009.
Regenold, W. T., Phatak, P., Makley, M. J., Stone, R. D., Kling, M. A.: Cerebrospinal fluid evidence of increased extra-mitochondrial glucose metabolism implicates mitochondrial dysfunction in multiple sclerosis disease progression. J Neurol Sci 275(1-2): 106-12, 2008.
Barr, C. S., Dvoskin, R. L., Yuan, Q., Lipsky, R. H., Gupte, M., Hu, X., Zhou, Z., Schwandt, M. L., Lindell, S. G., McKee, M., Becker, M. L., Kling, M. A., Gold, P. W., Higley, D., Heilig, M., Suomi, S. J., Goldman, D.: CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques. Arch Gen Psychiatry 65(8): 934-44, 2008.
Carpenter, L. L., Bayat, L., Moreno, F., Kling, M. A., Price, L. H., Tyrka, A. R., Kinkead, B., Owens, M. J., Nemeroff, C. B.: Decreased cerebrospinal fluid concentrations of substance P in treatment-resistant depression and lack of alteration after acute adjunct vagus nerve stimulation therapy. Psychiatry Res 157(1-3): 123-9, 2008.
Tolea, M. I., Black, S. A., Carter-Pokras, O. D., Kling, M. A.: Depressive symptoms as a risk factor for osteoporosis and fractures in older Mexican American women. Osteoporos Int 18(3): 315-22, 2007.
Horne, M. K., 3rd, Merryman, P. K., Cullinane, A. M., Cai, J., Martinez, P. E., Kling, M. A., Gold, P. W.: Activation of blood coagulation in patients with major depressive disorder during euglycemic hyperinsulinemia. Thromb Res 120(4): 517-21, 2007.
Kling, M. A., Alesci, S., Csako, G., Costello, R., Luckenbaugh, D. A., Bonne, O., Duncko, R., Drevets, W. C., Manji, H. K., Charney, D. S., Gold, P. W., Neumeister, A.: Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A. Biol Psychiatry 62(4): 309-13, 2007.
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Last updated: 06/30/2010
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