The laboratory studies the biochemical basis of fuel sensing by pancreatic islet cells, in particular the molecular mechanisms of glucose sensing and glucose stimulated insulin release (GSIR). The endocrine, neural and pharmacological modification of GSIR is another focus of the laboratory. The molecular genetic basis of glucokinase (GK) linked hypo-and hyperglycemia syndromes which are caused by more than 130 mutations of the GK gene continue to be a topic of intense interest. A newly discovered class of pharmacological agents called GK activators (GKAs) are studied with recombinant human wildtype and mutant GK, with intact pancreatic islet cells and in the intact animal to assess there therapeutic potential for the treatment of type II diabetes.
Sund NJ. Vatamaniuk MZ. Casey M. Ang SL. Magnuson MA. Stoffers DA. Matschinsky FM. Kaestner KH: Tissue-specific deletion of Foxa2 in
pancreatic B- cells results in hyperinsulinemic hypoglycemia Genes & Development 15(13): 1706-1715, 2001.
Cabrera-Valladares G, Matschinsky FM, Wang J, Fernandez-Mejia C : Effect of retinoic acid on glucokinase activity and gene expression in neonatal and adult cultured hepatocytes Life Sciences 68(25): 2813-2824, 2001.
Njolstad PR, Sovic O, Cuesta-Munoz A, Bjorkhaug L, Massa O, Barbetti F, Undlien DE, Shiota C, Magnuson MA, Molven A, Matschinsky FM, Bell GI : Neonatal diabetes mellitus due to complete glucokinase deficiency New England Journal of Medicine 344(21): 1588-1592, 2001.
Fernandez-Mejia C, Vega-Allende J, Rojas-Ochoa A, Rodriguez-Dorantes M, Romero-Navarro G, Matschinsky FM, Wang J, German MS : Cyclic adenosine 3’,5’-monophosphate increases pancreatic glucokinase activity and gene expression Endocrinology 142(4): 1448-1452, 2001.
O Massa, F Meschi, A Cuesta-Munoz, A Caumo, F Cerutti, S Toni, V Cherubini, L Guazzarotti, N Sulli, FM Matschinsky, R Lorini, D Iafusco, F Barbetti, and Italian Society of Paediatic Endocrinology and Diabetes (SIEDP): High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI. Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetes (SIEDP) Diabetologia 44(7): 898-905, uly 2001.
FM Matschinsky: Ebb and tide of glucokinase Int J Exp Diabetes Res 2(3): 168-171, January 2001.
Grimsby J, Coffey JW, Dovorozniak MT, Magram J, Li G, Matschinsky FM, Shiota C, Kaur S, Magnuson MA, Grippo JF : Characterization of glucokinase regulatory protein deficient mice Journal of Biological Chemistry 275(1): 7829-7831, 2000.
Newgard C.B. and Matschinsky FM : Substrate Control of Insulin Release Chapter 5, Section 7: The Endocrine System, Vol. II: The Endocrine Pancreas and Regulation of Metabolism, Handbook of Physiology. Oxford University Press, Page: 125-151, 2000.
Grimsby J, Coffey JW, Dovorozniak MT, Li G, Matschinsky FM, Shiota C, Magnuson MA, Grippo JF: Characterization of glucokinase regulatory protein deficient mice Diabetes Abstracts (Suppl. 1): #1775 48: A402, 1999.
Davis EA, Cuesta-Mu„§oz A, Raoul M, Buettger C, Sweet I, Moates M, Magnuson MA, Matschinsky FM: Mutants of Glucokinase Cause Hypo- and Hyperglycemia Syndromes and Their Analysis Illuminates Fundamental Quantitative Concepts of Glucose Homeostasis Diabetologia 42(10): 1175-1186, 1999.
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Last updated: 03/09/2012
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