faculty photo

Thomas P. Cappola

Assistant Professor of Medicine
Department: Medicine
Contact information
6 Penn Tower
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-0805
Fax: 215-615-0828
Email: thomas.cappola@uphs.upenn.edu
Graduate Group Affiliations
Publications

Search PubMed for articles
Links
Search PubMed for articles
 Penn CVI/IDOM Complex Genomics Initiative
Cardiovascular Division Faculty
Penn Health Profile
Education
A.B. (Chemistry)
Princeton University, 1991.
 MD ( Medicine)
Harvard Medical School, 1995.
 Sc.M. (Clinical Investigation )
Johns Hopkins University, 2003.
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Description of Research Expertise

Dr. Cappola’s laboratory studies mechanisms of cardiac remodeling in human subjects. Their specific biologic focus is cardiac transcription factors and transcriptional regulation as a therapeutic target. They employ a variety of approaches in human subjects, including large scale gene expression studies, SNP-association, biomarkers, and proof-of-concept studies of novel therapeutics. They collaborate with molecular cardiology to explore related questions in murine models.

Selected Publications

Barouch LA, Cappola TP, Harrison RW, Crone JK, Burnett AL, Hare JM: Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and hypertrophic cardiac remodeling in mice. J Mol Cell Cardiol 35(6): 637-644, June 2003.

 Cappola TP, Cope L, Cernetich A, Barouch LA, Irizarry RA, Parmigiani G, Durrani S, Lavoie T, Hoffman EP, Ye SQ, Garcia JGN, Hare JM: Deficiency of different nitric oxide synthase isoforms activates divergent transcriptional programs in cardiac hypertrophy. Physiological Genomics 14(1): 25-34, June 2003.

 Horwitz PA, Epstein JA, Lepore JJ, Parmacek MS, Kao AC, Desai S, Goldberg LR, Jessup ML, Cappola, TP: Novel Predictors of Cardiac Allograft Rejection Determined by Peripheral Blood Gene Expression. American Heart Association Scientific Sessions 2003.

 Barouch LA, Harrison RW, Skaf MM, Rosas GO, Cappola TP, Kobeissi ZA, Hobai IA, Lemmon CA, Burnett AL, O’Rourke B, Rodriguez ER, Huang PL, Lima JAC, Berkowitz DE, Hare JM: Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature 416(6878): 337-339, 2002.

 Cappola TP, Felker GM, Kao WL, Hare JM, Baughman KL, Kasper EK: Pulmonary hypertension and risk of death in cardiomyopathy: patients with myocarditis are at higher risk. Circulation 105: 1663-1668, 2002.

 Cappola TP, Rah B, Durrani S, Berkowitz DE, Hoffman E, Hare JM: NOS3 deficiency is associated with a shift toward pro-oxidant gene expression in murine myocardium. American College of Cardiology Scientific Sessions March 2002.

 Durrani S, Cappola TP, Rah B, Berkowitz DE, Hoffman E, Hare JM: Assessment of the canine myocardial transcriptome in heart failure using redundant cross-species oligonucleotide arrays. American College of Cardiology Scientific Sessions March 2002.

 Cappola TP, Cernetich A, Rah B, Durrani SA, Berkowitz DE, Hoffman EP, Hare JM: Nitric oxide deficiency modulates myocardial Gene transcription in a load-independent manner: implications for the pathogenesis of ventricular hypertrophy. Asia-Pacific Scientific Forum: The Genomic Revolution April 2002.

 Cappola TP, Kass DA, Nelson GS, Berger RD, Rosas GO, Kobeissi ZA, Marbán E, Hare, JM: Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy. Circulation 104(20): 2407-2411, 2001.

 Cappola TP, Felker GM, Kao WL, Hare JM, Baughman KL, Kasper EK: Pulmonary hypertension and risk of death in cardiomyopathy: patients with myocarditis are at higher risk. Heart Failure Society of America Scientific Sessions September 2001.
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Last updated: 10/03/2008
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