Gary Koretzky

Leonard Jarett Professor of Pathology and Laboratory Medicine

Department: Pathology and Laboratory Medicine

Contact information

415 BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104-6160

Office: (215) 746-5522
Fax: (215) 746-5525

Email:
koretzky@mail.med.upenn.edu

Graduate Group Affiliations

Publications

Search PubMed for articles

Links
Search PubMed for articles
Immunology graduate group faculty webpage.
Primary Work Website
Cell and Molecular Biology graduate group faculty webpage.

Education
B.A.
Cornell University , 1978.
Ph.D.
University of Pennsylvania , 1984.
M.D.
University of Pennsylvania , 1984.
(Master of Arts, Honorary)
University of Pennsylvania, 1999.

Permanent link

Description of Research Expertise

Research Interests
- Role of adaptor proteins in immune cell develoment and function
- Signals leading to T cell activation and termination of T cell responses
- In vitro and in vivo function of mast cells and neutrophils
- Signals leading to specification of blood vessels and lymphatics

Key words: signal transduction, adaptor proteins, SLP-76, DGK-zeta, T-cell activation, TCR signaling.

Description of Research
Our laboratory studies the regulation of signaling events which lead to hematopoietic cell development and function. We make extensive use of genetically altered mice for these studies. To date, we have identified three novel adapter proteins and have made mice deficient in each of these molecules. We have also investigated the role of enzymes by targeted gene deletion. Collectively these studies have provided new insights into how these proteins serve as regulators of multiple lineages in the hematopoietic system.

Rotation Projects for 2006-2007
Studies of the molecular and biochemical role of adapter proteins in hematopoietic cell development and growth.

Lab personnel:
Farhad Abtahian (Graduate Student)
Natalie Bezman (Graduate Student)
Regina Clemens (Graduate Student)
Marisa Juntilla (Graduate Student)
Ben Olenchock (Graduate Student)
Michael Silverman (Graduate Student)
Martha Jordan, PhD (Instructor)
Taku Kambayashi, MD/PhD (Postdoctoral Fellow)
Jonathan Maltzman, MD/PhD (Postdoctoral Fellow)
Gael Menasche, PhD (Postdoctoral Fellow)
Kim Nichols, MD (Visiting Scholar)
Selene Nunez, PhD (Postdoctoral Fellow)
Jessica Austin (Research Specialist)
Emily Chen (Research Specialist)
Lisa Kovoor (Research Specialist)

Selected Publications

Wu, J.N., Jordan, M.S., Silverman, M.A., Peterson, E.J., Koretzky, G.A.: Differential requirement for adapter proteins SLP-76 and ADAP in FcepsilonR1 signaling and mast cell function. J. Immunol. 172: 6768-74, 2004.

Chiang, Y.J., Sommers, C.L., Jordan, M.S., Gu, H., Samelson, L.E., Koretzky, G.A., Hodes, R.J.: Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice. J. Exp. Med. 1: 25-34, 2004.

Artis, D., Villarino, A., Silverman, M., He, W., Thornton, E.M., Mu, S., Covey, T.M., Huang, E., Yoshida, H., Koretzky, G.A., Goldschmidt, M., Wu, G., de sauvage, F., Millar, H.R.P., Sairs, C.J.M., Scott, P., Hunter, C.A.: The IL-27R (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J. Immunol. 173: 5626-34, 2004.

Cannons, J.L., Hill,B., Yu, L.J., Mijares, L.A., Dombroski, D., Nichols, K.E., Antonellis, A., Koretzky, G.A., Gardner, K., Schwartzberg, P.L.: SAP modulates Teta2 differentiation and PKC-theta mediated activation of NF-KB. Immunity 21: 693-706, 2004.

Clemens, R.A., Chung, E.Y., Gheith, S., Singer, A.L., Koretzky, G.A., Peterson, E.J.: PRAM-1 is required for optimal integrin-dependent neutrophil function. Mol. Cell. Biol. 24: 10923-32, 2004.

Wu, J.N. and Koretzky, G.A.: SLP-76 Family of Adapter Proteins. Seminars in Immunology 16: 379-393, 2004.

Abtahian, F, Guerriero, A., Sebzda E, Lu, M-M, Zhou, R, Mocsai A, Meyers, EE, Huang, B, Jackson, D, Ferrari, VA, Tybulewicz V, Lowell CA, Lepore, JJ, Koretzky, GA and Kahn, ML.: Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science 299: 247-251, 2003.

Zhong, S-P., Hainey, E.A., Jordan, M.S., Nichols, K.E., Olenchock, B.A., Shen, H., and Koretzky, G.A.: Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. Nat. Immunol. 4: 882-890, 2003.

Zhong, X-P, Maltzman, J, Haine EA, Koretzky, GA: Transcriptional regulation of Src homology 2 domain-containing leukocyte phosphoprotin of 76 kDa: dissection of key promoter elements. J. Immunol. 171: 6621-6629, 2003.

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