(1) Behavioral pharmacology; (2) Mechanism of action of antidepressant and antianxiety medications; (3) Stress neurobiology and psychiatric disorders
Antidepressants; tranquilizers; stress; serotonin; microdialysis; knockouts; behavior
Behavioral pharmacology in rats and mice; microdialysis measurement of extracellular concentrations of monoamines in conscious rats and mice; behavioral analysis of knockout mice; stereotaxic surgery; effects of brain lesions and neurotoxins on behavior; central drug administration; in vitro ligand binding; histology; radioimmunoassay; and HPLC analysis of brain monoamines
Current studies focus on the role of specific neurotransmitters, such as serotonin (5-HT), in the behavioral effects of antidepressant and anxiolytic drugs. Animal models for depression and anxiety are used to evaluate the potential efficacy of different neurotransmitter and peptide receptors for clinical therapeutic effects, to identify brain regions associated with behavioral responses to drugs, and to construct and evaluate pharmacological models for improving the efficacy of psychiatric medications. The participation of central 5-HT neurotransmission in depression, anxiety and neuroendocrine regulation associated with behavioral stress is specifically being investigated. Microdialysis procedures are used to measure the release of neurotransmitters in discrete regions of awake freely-moving rats or mice. These studies provide information on the regulation of the release of neurotransmitters in different brain regions, determine environmental and behavioral conditions that alter the release of neurotransmitters, and measure the effects of drugs during behavioral performance. Finally, studies of different inbred mouse strains or knockout mice are examining genetic factors associated with complex behaviors and the behavioral effects of psychotherapeutic medications.
Featherstone, R., Tatard-Leitman, V., Suh, J., Lin, R., Lucki, I. and Siegel, S.: Electrophysiological and behavioral responses to ketamine in mice with reduced Akt1 expression. Psychopharmacology 2013.
Balu, D.T., Hodes, G.E., Turner, J.R., Hill, T.E., Blendy, J.A. and Lucki, I. : Brain monoamines and responses to antidepressant drugs in MRL/MpJ versus C57BL/6J and mice. Neuropharmacology 2013.
Carlin, J., Hill-Smith, T.E., Lucki, I. and Reyes, T.M. : Reversal of dopamine system dysfunction in response to high fat diet. Obesity 2013.
Balu DT, Carlson GC, Talbot K, Kazi H, Hill-Smith TE, Easton RM, Birnbaum MJ, Lucki I.: Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function. Hippocampus 22(2): 230-240, 2012.
Multani, P.K., Hodge, R., Estevez, M., Abel, T., Kung, H., Choi, S., Talbot, K., Brookshire, B., Lucki, I., Nall, A.H., Doyle, G.A. and Lohoff, F.W.: VMAT1 deletion causes hippocampal apoptosis and neurocognitive deficits. Neuroscience 2012.
Hodes, G.E., Brookshire, B., Hill-Smith, T.E., Teegarden, S.L., Berton, O. and Lucki, I. : Strain differences in the effects of chronic corticosterone exposure in the hippocampus. Neuroscience 222: 269-280, 2012.
Espallergues J, Teegarden SL, Veerakumar A, Boulden J, Challis C, Jochems J, Chan M, Petersen T, Deneris E, Matthias P, Hahn CG, Lucki I, Beck SG, Berton O.: HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience. Journal of Neuroscience 32(13): 4400-4416, 2012.
Ho N, Balu DT, Hilario MR, Blendy JA, Lucki I.: Depressive phenotypes evoked by experimental diabetes are reversed by insulin. Physiology & Behavior 105(3): 702-708, 2012.
Carr, G.V., Schechter, L.E. and Lucki, I. : Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats.
Psychopharmacology 213: 499-507, 2011.
Cohen, J.W., Louneva, N., Han, L.-Y., Hodes, G.E., Wilson, R.S., Bennett, D.A., Lucki, I. and Arnold, S.E. : Chronic corticosterone exposure alters postsynaptic protein levels of PSD-95, NR1 and synaptopodin in the mouse brain. Synapse 65: 763-770, 2011.
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Last updated: 01/16/2013
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