faculty photo

Malek Kamoun

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine
Contact information
Hospital of the University of Pennsylvania
7.020 Founders Pavilion
3400 Spruce St.
Philadelphia, PA 19104-4283
Office: (215) 662-4022
Fax: (215) 349-5090
Email: MALEKKAM@MAIL.MED.UPENN.EDU
Graduate Group Affiliations
Publications

Search PubMed for articles
Links
Search PubMed for articles
 Immunology graduate group faculty webpage.
Education
B.S.
Université de Strasbourg (France), 1970.
 M.D.
Université de Pierre et Marie Curie (Paris, France), 1975.
 Ph.D. (Immunogenetics)
Université de Pierre et Marie Curie (Paris, France), 1977.
Permanent link
 

Description of Research Expertise

Research Interests

Regulatory pathways of T-cell activation, HLA genes and molecules.

Research Summary

Dr. Kamoun's research interest are in the regulation of lymphocyte growth. Molecular, genetic and immunological techniques are used to study the role of a novel Ser/Thr Phosphoprotein Phosphatase (RAPP-36) in the regulation of lymphocyte growth.

A second focus of the laboratory is to define the extent and nature of HLA genetic diversity and to understand the biological relevance of MHC variation. High resolution DNA-based technology is being developed and used as an important step for an accurate determination of HLA alleles of marrow/stem cell unrelated donor and recipient.

Selected Publications

Kamoun M: Diagnostic Performance and Predictive Value of Anti-citrullinated Peptide Antibodies for Diagnosis of Rheumatoid Arthritis: Toward More Accurate Detection? Clin Chem. 51(1): 12-3, Jan 2005.

 Li J, Gran B, Zhang GX, Rostami A, Kamoun M: IL-27 subunits and its receptor (WSX-1) mRNAs are markedly up-regulated in inflammatory cells in the CNS during experimental autoimmune encephalomyelitis. J Neurol Sci. Page: in press, 2005.

 Peter Yang, George Preti, Jae Kwak, Jon Wahl, Alan Wilse, Kunio Yamazaki, Maryanne Curran, Julie Mennella, Allison Steinmeyer, Malek Kamoun, Gary Beauchamp: HLA-related Odorants in Humans. 27th Annual Meeting of the Association for Chemoreception Sciences April 2005.

 Simin Goral, Malek Kamoun, Roy Bloom, Marty Sellers, Alden Doyle, Robert Grossman, Ali Naji, James Markmann, Pinar Eren: Impact of sensitization to HLA Class I and Class II antigens (AG) on receiving a second kidney trnasplant (Tx) after a failed graft: Report for a transplant center using a stringent HLA crossmatching (XM) strategy. American Transplant Congress 2005, Seattle, WA May 2005.

 Simin Goral, Malek Kamoun, Roy Bloom, Marty Sellers, Alden Doyle, Robert Grossman, Ali Naji, James Markmann, Pinar Eren: Managing a large kidney transplant waiting list: Impact of sensitization to HLA antigens and patient's listing status on waiting time. American Transplant Congress 2005, Seattle, WA May 2005.

 Williams TW, Weedn V, Kamoun M: Identity Assessment Tietz Textbook of Clinical Chemistry. Burtis, Ashwood, Bruns (eds.). WB Saunders, 2005 Notes: 4th Ed.

 Kamoun M and Williams TW: Molecular HLA Typing. Molecular Pathology in Clinical Practice. Leonard, GB (eds.). New York, Springer-Verlag, 2005.

 Gourley IS, DeNofrio D, Rand W, Desai S, Loh E, and Kamoun M.: The effect of recipient cytokine gene polymorphism on cardiac transplantation outcome. Human Immunology 65: 248-254, 2004.

 Lynn J, Knight AK, Kamoun M, Levinson AI: A 55-year-old man with hypogammaglobulinemia, lymphopenia, and unrelenting cutaneous warts. J Allergy Clin Immunol. 114(2): 409-414, Aug 2004.

 Kamoun M, Sellers MT: Changing the priority for HLA matching in kidney transplantation. N Engl J Med 350(20): 2095-2096, 2004.
back to top
Last updated: 09/30/2008
The Trustees of the University of Pennsylvania
 
Untitled Document