Research in the laboratory is focused on how diet, both prenatally and postnatally, can affect the development and function of central nervous system pathways that regulate appetite and reward. Using mouse models, we are interested in behavioral, gene expression, functional neuroanatomical and epigenetic endpoints.
In the prenatal period, we are interested in how either maternal undernutrition or overnutrition can affect the development of CNS circuitry in the offspring. A primary focus involves understanding dysregulation within the dopamine and opioid systems. Additionally, in the postnatal period, we are interested in how chronic ingestion of a high fat diet and the resultant obesity can alter CNS pathways that regulate appetite and reward-related behavior. The lab is interested in defining epigenetic mechanisms that link nutritional changes with altered gene expression in the brain.
Additionally, research in the lab examines neuroinflammation, primarily in the hypothalamus, in an effort to understand the importance of the CNS inflammatory response to external stressors.
Zivjena Vucetic, Jessica Kimmel and Teresa M Reyes: Chronic High-Fat Diet Drives Postnatal Epigenetic Regulation of μ-Opioid Receptor in the Brain
Neuropsychopharmacology 36: 1199-1206, 2011.
Vucetic Zivjena, Kimmel Jessica, Totoki Kathy, Hollenbeck Emily, Reyes Teresa M: Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes. Endocrinology 151(10): 4756-64, Oct 2010.
Vucetic Z, Totoki K, Schoch H, Whitaker K W, Hill-Smith T, Lucki I, Reyes T M: Early life protein restriction alters dopamine circuitry. Neuroscience 168(2): 359-70, Jun 2010.
Bale Tracy L, Baram Tallie Z, Brown Alan S, Goldstein Jill M, Insel Thomas R, McCarthy Margaret M, Nemeroff Charles B, Reyes Teresa M, Simerly Richard B, Susser Ezra S, Nestler Eric J: Early life programming and neurodevelopmental disorders. Biological psychiatry 68(4): 314-9, Aug 2010.
Inoue Koki, Valdez Glenn R, Reyes Teresa M, Reinhardt Lindsay E, Tabarin Antoine, Rivier Jean, Vale Wylie W, Sawchenko Paul E, Koob George F, Zorrilla Eric P: Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat. The Journal of pharmacology and experimental therapeutics 305(1): 385-93, Apr 2003.
Serrats Jordi, Schiltz Jennifer C, García-Bueno Borja, van Rooijen Nico, Reyes Teresa M, Sawchenko Paul E: Dual roles for perivascular macrophages in immune-to-brain signaling. Neuron 65(1): 94-106, Jan 2010.
Clarke K J, Whitaker K W, Reyes T M: Diminished metabolic responses to centrally-administered apelin-13 in diet-induced obese rats fed a high-fat diet. Journal of neuroendocrinology 21(2): 83-9, Feb 2009.
Reyes Teresa M, Sawchenko Paul E: Involvement of the arcuate nucleus of the hypothalamus in interleukin-1-induced anorexia. The Journal of neuroscience : the official journal of the Society for Neuroscience 22(12): 5091-9, Jun 2002.
Reyes Teresa M, Walker John R, DeCino Casey, Hogenesch John B, Sawchenko Paul E: Categorically distinct acute stressors elicit dissimilar transcriptional profiles in the paraventricular nucleus of the hypothalamus. The Journal of neuroscience : the official journal of the Society for Neuroscience 23(13): 5607-16, Jul 2003.
Reyes T M, Lewis K, Perrin M H, Kunitake K S, Vaughan J, Arias C A, Hogenesch J B, Gulyas J, Rivier J, Vale W W, Sawchenko P E: Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proceedings of the National Academy of Sciences of the United States of America 98(5): 2843-8, Feb 2001.
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Last updated: 04/02/2013
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