faculty photo

Jorge Henao-Mejia

Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
The Institute for Immunology
Department of Pathology and Laboratory Medicine
Perelman School of Medicine,University of Pennsylvania
The Children's Hospital of Philadelphia
421 Curie Boulevard
Biomedical Research Building II/III, Room 312
Philadelphia, PA 19104
Lab: 215-898-2212
Graduate Group Affiliations
Education:
M.D. (Medicine)
University of Antioquia, Colombia, 2005.
Ph.D. (Microbiology and Immunology)
Indiana University, 2009.
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Selected Publications

Kotzin JJ, Spencer SP, McCright SJ, Kumar DB, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CC, Virtue AT, Zhu S, Bailis W, Stein J, Hughes C, Raj A, Wherry EJ, Goff LA, Klion AD, Rinn JL, Williams A, Flavell RA, Henao-Mejia J.: The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature 537(7619), September 2016 Notes: Published under his first and last hyphenated name.

Henao-Mejia J*, Williams A*, Rongvaux A, Stein J, Hughes C, Flavell RA* (*Corresponding authors): Generation of genetically modified mice using the CRISPR/Cas9 genome editing system. Cold Spring Harb Protoc. (2), Feb 2016 Notes: Published under his first and last hyphenated name.

Henao-Mejia J*, Elinav E*, Jin C*, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA: Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482(7384): 179-185, February 2012 Notes: *These authors contributed equally to this work. Published under his first and last hyphenated name.

Henao-Mejia J,* Williams A*, Goff LA, Staron M, Licona-Limon P, Kaech SM, Nakayama M, Rinn JL, Flavell: The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis. Immunity 38(5): 1-14, May 2013 Notes: *These authors contributed equally to this work. Published under his first and last hyphenated name.

Henao-Mejia J*, Strowig T*, Elinav E*, Flavell R: Inflammasomes in health and disease. Nature 481(7381): 278-286, January 2012 Notes: *These authors contributed equally to this work. Published under his first and last hyphenated name.

Henao-Mejia J.*, Elinav E*, Thaiss CA*, Flavell RA: Inflammasomes and Metabolic Disease. Annu Rev Physiol 76: 57-78, Nov 2014 Notes: Published under his first and last hyphenated name.

Wlodarska M, Nowarski R, Thaiss CA, Henao-Mejia J, Zhang JP, Frankel G, Hao L, Philbrick WM, Elinav E, Finlay BB, Flavell RA: NLRP6 inflammasome regulates the intestinal host-microbial interface by orchestrating globlet cell-mediated mucus secretion. Cell 156(5): 1045-1059, February 2014 Notes: Published under his first and last hyphenated name.

Elinav E,* Strowig T,* Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA: NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145(5): 745-757, May 2011 Notes: *These authors contributed equally to this work. Published under his first and last hyphenated name.

Hacisuleyman E., Goff LA, Trapnell C, Sauvageau DC, Hendrickson DR, Kelley P, McClanahan A, Henao-Mejia J, Sun L, Engreitz J, Guttman M, Lander ES, Flavell RA, Lodish HF, Raj A, Rinn JL: Trans-chromosomal and nuclear matrix interactions require a lincRNA that escapes X chromosome inactivation. Nat Struct Mol Biol 21(2): 198-206, February 2014 Notes: Published under his first and last hyphenated name.

Eisenbarth SC*, Williams A*, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature 484(7395): 510-513, April 2012 Notes: *These authors contributed equally to this work. Published under his first and last hyphenated name.

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Last updated: 10/31/2016
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