faculty photo

Jane Marie Vanderkooi

Emeritus Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics

Contact information
909C Stellar-Chance Laboratories
University of Pennsylvania
School of Medicine
Philadelphia, PA 19104
Office: (215) 898-8783
Fax: (215) 573-2042
B.A. (Chemistry)
Central College, Pella, IA, 1967.
Ph.D. (Biochemistry)
St. Louis University, 1971.
Permanent link

Description of Research Expertise

Hydration of proteins and macromolecules.

Stability of proteins and peptides in sugar (trehalose) matrices

Photoreactions of tryptophan and porphyrins.

Techniques: fluorescence, phosphorescence, infrared, protein isolation

Selected Publications

Dalosto, S.D., Vanderkooi, J. M., Sharp, K. A. : Vibrational Stark effects on carbonyl, nitrile and nitrosyl compounds including heme ligands, CO, CN and NO studied with density functional theory. J. Phys. Chem. 108: 6450-57, 2004.

Zelent, B., Kaposi, A. D., Nucci, N. V., Sharp, K. A., Dalosto, S. D., Wright, W. W., Vanderkooi, J. M.: Water channel of horseradish peroxidase studied by the charge-transfer absorption band of ferric heme. J. Phys. Chem. B. (Festschrift in honor of Gerald Small), 2004.

Pontratov, V.V., Friedrich, J. Marlovic, D., Scheer, H., Vanderkooi, J. M. : Spectral diffusion experiment with a denatured protein. J. Phys. Chem. B. 108: 1109-14, 2004.

Lesch, H., Schlichter, J., Friedrich, J., Vanderkooi, J. M.: Molecular Probes: What is the range of their interaction with the environment? Biophys. J. 86: 467-72, 2004.

Quantum calculations of heme proteins. Biophysical Society. February 2003 Notes: San Antonio Texas (S. Dalosto presenter).

Kaposi, A. D., Prabhu, N. V., Dalosto, S. D., Sharp, K. A., Wright, W. W., Stavrov, S. S., Vanderkooi, J. M. : Solvent dependent and independent motions of CO-horseradish peroxidase examined by infrared spectroscopy and molecular dynamics calculations. Biophys. Chem. 106: 1-14, 2003.

Kaposi AD., Wright WW., Fidy J., Stavrov SS., Vanderkooi JM., Rasnik I.: Carbonmonoxy horseradish peroxidase as a function of pH and substrate: influence of local electric fields on the optical and infrared spectra. Biochemistry 40(12): 3483-91, Mar 27 2001.

Argyris EG., Vanderkooi JM., Paterson Y.: Mutagenesis of key residues identifies the connection subdomain of HIV-1 reverse transcriptase as the site of inhibition by heme. European Journal of Biochemistry 268(4): 925-31, Feb 2001.

Rasnik, I, Sharp, K., Fee, J. A. & Vanderkooi, J. M: Spectral analysis of cytochrome c: Effect of heme conformation, axial ligand, peripheral substituents and local electric fields. J. Phys. Chem. B 105: 282-286, 2001.

Sharp, K., Mandan, B., Manas, E. S., & Vanderkooi, J. M: Water structure changes induced by hydrophobic and polar solutes revealed by simulations and IR spectroscopy. J. Chem. Phys 114: 1791-1796, 2001.

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Last updated: 11/12/2007
The Trustees of the University of Pennsylvania