Garret A. FitzGerald

Robert L. McNeil, Jr., Professor in Translational Medicine and Therapeutics

Department: Medicine

Contact information

Department of Pharmacology
153 Johnson Pavilion
3620 Hamilton Walk
Philadelphia, PA 19104-6084

Office: (215) 898-1185
Fax: (215) 573-9135

Email:
garret@spirit.gcrc.upenn.edu

Graduate Group Affiliations

Publications

Search PubMed for articles

Links
Search PubMed for articles
"Garret FitzGerald, Renaissance Man," Penn Medicine, pg 6-11, Spring 2001.
Faculty Profile, Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania School of Medicine
Faculty Profile, Graduate Group in Pharmacological Sciences, University of Pennsylvania School of Medicine
Dr Garret A FitzGerald, University College Dublin Graduate, awarded RDS Boyle Medal, in association with The Irish Times
Faculty Profile, Penn Cardiovascular Institute, University of Pennsylvania School of Medicine
Faculty Profile, Department of Pharmacology, University of Pennsylvania School of Medicine

Education
MB, BCh (Honors, First Place)
University College, Dublin, Ireland, 1974.
Diploma (Statistics)
Trinity College, Dublin, Ireland, 1977.
M.Sc. (Statistics)
University of London, 1979.
M.D.
University College, Dublin, 1980.
D.Sc. (Hon Causa)
University of Edinburgh, UK, 2004.
D.Sc. (Hon Causa)
National University of Ireland (150th Anniversary), Dublin, Ireland, 2004.
M.D. (Hon Causa)
Johann Wolfganag Goethe University of Frankfurt, Germany, 2007.

Permanent link

Description of Research Expertise

The Pharmacology of COX Inhibition
A particular interest is to elucidate the cardiovascular biology of COXs and its implication for the use of aspirin, traditional NSAIDs and COX-2 inhibitors. Studies in mice and zebrafish complement studies of the genetic and environmental factors which modulate response to this interesting class of compounds.

Selected Publications

Kunieda T, Minamino T, Miura K, Katsuno T, Tateno K, Miyauchi H, Kaneko S, Bradfield CA, FitzGerald GA, Komuro I: Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circulation Res 102: 607-614, 2008.

Wang M, Lee E, Song W, Ricciotti E, Rader DJ, Lawson JA, Pure E, FitzGerald GA: Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation. Circulation 117: 1302-1309, 2008.

Song W-L, Wang M, Ricciotti E, Fries S, Yu Y, Grosser T, Reilly M, Lawson JA, FitzGerald GA: Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans. J Biol Chem 283: 1179-1188, 2008.

Reilly DF, Curtis AM, Cheng Y, Westgate EJ, Rudic RD. Paschos G, Morris J, Ouyang M, Thomas SA, FitzGerald GA: Peripheral circadian clock rhythmicity is retained in the absence of adrenergic signaling. Arterioscl Thromb VascBiol 28: 121-126, 2008.

FitzGerald GA: Translational therapeutics at the platelet vascular interface (Introduction). Arterioscl Thromb Vasc Biol 28: S3-S4, 2008.

FitzGerald GA: Translational therapeutics at the platelet vascular interface (Summary). Arterioscl Thromb Vasc Biol 28: S51-S52, 2008.

Curtis AM, Cheng Y, Kapoor S, Reilly D, Price TS, FitzGerald GA: Circadian variation of blood pressure and the vascular response to asynchronous stress. Proc Natl Acad Sci USA 104: 3450-3455, 2007.

Price TS, Lucitt MB, Wu W, Austin DJ, Pizarro A, Yocum AK, Blair IA, FitzGerald GA, Grosser T: EBP, a program for protein identification using multiple tandem mass spectrometry datasets. Molec Cell Prot 6: 527-536, 2007.

Yu Y, Fan J, Hui Y, Rouzer CA, Marnett LJ, Klein-Szanto AJ, FitzGerald GA, Funk CD: Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality. J Biol Chem 282: 1498-1506, 2007.

FitzGerald GA: Clinical pharmacology or translational medicine and therapeutics: Reinvent or rebrand and expand? Clin Pharmacol Therap 81: 19-20, 2007.

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