David F. Wilson

Professor of Biochemistry and Biophysics

Department: Biochemistry and Biophysics

Contact information

901A Stellar-Chance Laboratories
Philadelphia, PA 19104-6059

Office: (215) 898-6382
Fax: (215) 573-3787

Email:
wilsondf@mail.med.upenn.edu

Graduate Group Affiliations

Biochemistry and Molecular Biophysics

Publications

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Links
Search PubMed for articles
Biochemistry and Molecular Biophysics Graduate Group

Education
B.S.
Colorado State University, Fort Collins, Colorado , 1959.
Ph.D.
Oregon State University, 1964.

Permanent link

Description of Research Expertise

My research is on the regulation of cellular and tissue metabolism in vivo, with particular focus on the role of oxygen in tissue energy metabolism. This program covers several different tissues, including brain, liver, heart, and eye, and involves several models of ischemia/hypoxia and reoxygenation. We have developed an optical method for noninvasive measurement of oxygen, based on oxygen dependent quenching of phosphorescence, and are utilizing this technology for quantitative determine the oxygen dependence of tissue metabolism and function.

Selected Publications

Wilson, D.F. and Vinogradov, S.A. : “Tissue measurements using phosphorescence quenching.” In: “Fluorescence in Biomedicine” In press. B. Pogue and M-A. Mycek (eds.). Marcel Dekker, Inc. New York, 2003.

Soloviev V.D., Wilson D.F., Vinogradov S.A. : “3D phosphorescence lifetime imaging in turbid media: the forward problem” Applied Optics 42: 113-123, 2003.

Vinogradov, S.A., Fernandez-Seara, M.A., Biruski, D. and Wilson, D.F. : “A method for measuring oxygen distributions in tissue using frequency domain phosphorometry” Comp. Biochem. & Physiol. A 132(1): 147-152, 2002.

Wilson, D.F., Vinogradov, S.A., Dugan, B.W., Biruski, D., Waldron, L., and Evans, S.A. : “Measurement of tumor oxygenation using new frequency domain phosphorometers” Comp. Biochem. Physiol. 132(1): 153-159, 2002.

Shen, J., Creed, J., Zaitseva, T., Schears, G., Wilson, D.F., and Pastuszko, A. : “Changes in cortical oxygen pressure and o-tyrosine in response to bilateral carotid ligation and hemorrhage in newborn piglets” Oxygen Transport to Tissue XXII, Adv. Exptl. Med. Biol., in press 2002.

Zaitseva, T., Shen, J., Schears, G., Creed, J., Wilson, and Pastuszko, A. : “Effect of catecholamines on activity of Na,K-ATPase in neonatal piglet brain during posthypoxic reoxygenation” Comp. Biochem. and Physiol. 132(1): 139-145, 2002.

Schears, G., Shen, J., Creed, J., Zaitseva, T., Wilson, D.F., Greeley, W.J., and Pastuszko, A. : “Brain oxygenation during cardiopulmonary bypass and circulatory arrest” Adv. Exptl. Med. Biol. 510: 325-330, 2002.

Zaitseva, T., Schears, G., Shen, J., Creed, J., Wilson, D.F., Greeley W.J. and Pastuszko, A. : “Altered gene expression following cardiopulmonary bypass and cardiac arrest” Oxygen Transport to Tissue XXII, Adv. Exptl. Med. Biol., in press 2002.

Zaitseva, T., Creed, J., Schears, G., Shen, J., Knight, K., Wilson, D.F. and Pastuszko, A. : “Effect of hypoxia and ischemia on expression of selected genes in brain of newborn piglets” Adv. Exptl. Med. Biol. 510: 319-324, 2002.

Rozhkov, V., Wilson, David F., and Vinogradov, S. : “Phosphorescent Pd porphyrin-dendrimers: tuning core accessibility by varying the hydrophobicity of the dendrimer matrix” Macromolecules 35: 1991-1993, 2002.

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