My research is on the regulation of cellular and tissue metabolism in vivo, with particular focus on the role of oxygen in tissue energy metabolism. This program covers several different tissues, including brain, liver, heart, and eye, and involves several models of ischemia/hypoxia and reoxygenation. We have developed an optical method for noninvasive measurement of oxygen, based on oxygen dependent quenching of phosphorescence, and are utilizing this technology for quantitative determine the oxygen dependence of tissue metabolism and function.
Wilson David F: Programming and regulation of metabolic homeostasis. American journal of physiology. Endocrinology and metabolism 308(6): E506-17, Mar 2015.
Wilson David F, Harrison David K, Vinogradov Andrei: Mitochondrial cytochrome c oxidase and control of energy metabolism: measurements in suspensions of isolated mitochondria. Journal of applied physiology (Bethesda, Md. : 1985) 117(12): 1424-30, Dec 2014.
Wilson David F, Vinogradov Sergei A: Mitochondrial cytochrome c oxidase: mechanism of action and role in regulating oxidative phosphorylation. Journal of applied physiology (Bethesda, Md. : 1985) 117(12): 1431-9, Dec 2014.
Pastuszko Peter, Schears Gregory J, Greeley William J, Kubin Joanna, Wilson David F, Pastuszko Anna: Granulocyte colony stimulating factor reduces brain injury in a cardiopulmonary bypass-circulatory arrest model of ischemia in a newborn piglet. Neurochemical research 39(11): 2085-92, Nov 2014.
Wilson David F: Regulation of cellular metabolism: programming and maintaining metabolic homeostasis. Journal of applied physiology (Bethesda, Md. : 1985) 115(11): 1583-8, Dec 2013.
Yu J, Ramadeen A, Tsui A K Y, Hu X, Zou L, Wilson D F, Esipova T V, Vinogradov S A, Leong-Poi H, Zamiri N, Mazer C D, Dorian P, Hare G M T: Quantitative assessment of brain microvascular and tissue oxygenation during cardiac arrest and resuscitation in pigs. Anaesthesia 68(7): 723-35, Jul 2013.
Hu Tina, Beattie W Scott, Mazer C David, Leong-Poi Howard, Fujii Hiroko, Wilson David F, Tsui Albert K Y, Liu Elaine, Muhammad Maimoona, Baker Andrew J, Hare Gregory M T: Treatment with a highly selective β₁ antagonist causes dose-dependent impairment of cerebral perfusion after hemodilution in rats. Anesthesia and analgesia 116(3): 649-62, Mar 2013.
Wilson David F, Harrison David K: Simultaneous monitoring of brain and skin oxygenation during haemorrhagic shock in piglets. Advances in experimental medicine and biology 789: 51-7, 2013.
Wilson David F, Harrison David K, Vinogradov Sergei A: Oxygen, pH, and mitochondrial oxidative phosphorylation. Journal of applied physiology (Bethesda, Md. : 1985) 113(12): 1838-45, Dec 2012.
Pastuszko, Peter. Schears, Gregory J. Pirzadeh, Afsaneh. Kubin, Joanna. Greeley, William J. Wilson, David F. Pastuszko, Anna.: Effect of granulocyte-colony stimulating factor on expression of selected proteins involved in regulation of apoptosis in the brain of newborn piglets after cardiopulmonary bypass and deep hypothermic circulatory arrest. Journal of Thoracic & Cardiovascular Surgery 143(6): 1436-42, Jun 2012.
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