An international conference organized by the Master of Public Administration Program, in collaboration with The African & Caribbean Business Council.
While other regions of the world are making strides in improving the living standards of their citizens, Sub-Saharan Africa (SSA) is still trapped in poverty with more than 40% of its 600 million people living below the internationally recognised absolute poverty level of US$ 1 per day. Several reports highlight corruption as one of the institutional and systemic problems responsible for keeping million of Africans under absolute poverty. In fact, the 2008 Transparency International report demonstrates a direct link between corruption and failure of societal institutions to effectively achieve the Millennium Development Goals (MDGs) in SSA. It is a serious concern that the goals of halving poverty in SSA by the year 2015 from the level of 1990 will not be met.
Department of Radiation OncologyRadiation Biology Research DivisionAll Division Meeting 12am-1pm in Room 8-146A; Lunch will be served at 11:45am
More details to follow!
Seth Himelhoch, MD, "Hepatitis C Virus - Risk Assessment and Treatment Considerations Among People with Serious Mental Illness"
Time: 12:00 PM Location: 251 BRB II/III
Thomas B. Jansson, M.D., Ph.D.
Professor, Head of the Division for Basic Reproductive Sciences
and Vice Chair of Research at the Department of Obstetrics and Gynecology
University of Colorado Denver
The role of mTOR signaling in placental nutrient sensing and maternal-fetal resource allocation
Time: 12:00 PM Location: 132 Hill Pavilion
Satoshi H. Namekawa, Ph.D.
Division of Reproductive Sciences and Developmental Biology
Cincinnati Children's Hospital Medical Center
Department of Pediatrics
University of Cincinnati College of Medicine
Germline epigenome and sex chromosome inactivation
*co-sponsored with the Center for Animal Transgenesis and Germ Cell Research
Noah Hoffman & Brian Riff
Karl Bezak & Therese Bitterman
Alyssa Kriegermeier & Tatyana Kushner
Nina Sainath & Kirk Wangensteern
Problem Based Learning
"The initiation, regulation and therapeutic targeting of inflammation in pediatric cancer"
Grossman Auditorium, The Wistar institute
Mentor: Edward Behrens, MD, PhD
Toll-like receptor 9 and interferon-gamma receptor signaling suppress the B cell fate of uncommitted progenitors in mice"
Join the immunology community as we celebrate the new year. All are welcome!
Mentor: Jan Burkhardt, PhD
"Opposing Actin Networks Modulate the Mechano-Activation of the Integrin LFA-1 During Immunological Synapse Formation"
University of Pennsylvania
Cancer Metabolism – Basic Biology and Translational Opportunities
Transduction and Modulation of Touch Sensitivity in C. elegans.
The Community Scholars-in-Residence program is currently accepting applications to begin in January 2015. Applications are due Monday, September 15th and application materials are located here - http://www.med.upenn.edu/chbr/training.shtml
Center for Pharmacoepidemiology Research and Training (CPeRT - RIP) Research in Progress Series Presentation
James Lewis, MD, MSCE will present his talk titled:
"Has the time come for PWAS?"
12:00pm - 1:00pm BRB252
This talk is part of the CPeRT RIP Series that is scheduled every month with various speakers and topics of research
Class of '62 Auditorium, JMB
Reunion Auditorium, JMB
"CD19: cancer marker or cancer maker?"
Assitant Professor of Dermatology
Michael Cho: Shared VH1-46 gene usage in pemphigus vulgaris: implications for disease development
Christoph Ellebrecht: Defining clonal relationships among anti-desmoglein 3 isotype repertoires in pemphigus vulgaris
Class of '62, JMB
Class of '62, JMB
Seminar Title: The biogenesis of chromosome translocations
Seminar title: Role of metabolism in cancer
Robert A. Copeland, Ph.D. (Epizyme), "Protein methyl transferase inhibitors as personalized cancer therapeutics"
James E. Bruce, Ph.D. (U of Washington), "Protein interactions in celss: finding connections"
Nikolaus Grigorieff, Ph.D. (Janella Farm/Brandeis), "The power of Cryo-EM: between hype and reality"
Floyd E. Romesberg, Ph.D. (Scripps Research Institute), "Expansion of the genetic code"
"Some problems with splines"
Martin Clyde, PhD Professor Department of Mathematics and Statistics Texas Tech University
Abstract: Smoothing splines are a powerful tool for representing data as long as the data has enough nice properties. In this talk I will discuss three problems and what we are doing to solve them.
1)1) L1 splines rather than L2 splines useful when the data is not normal. Work with Masaki Nagahara.
2)2) The underlying state space is not Euclidian. Work with Wenzhen Fan and Jingyong Su.
3)3) Very large data sets such as those encountered in tracking eye and head movement. Work with Bijoy Ghosh and Jennifer Emerson.
Problem 1 arises when the data has many outliers such as climate data. L1 splines were much more efficient than L2 splines. Problem 2 arose in a certain tracking problem that was best stated as a problem on the manifold of lines in R3. It also arose in considering a certain climate data and was reduced to the manifold of intervals. Problem 3 arose in the study of head and eye movement. Data sets of 300000 to 600000 points were used.
"Inference for dynamic treatment regimes"
Eric Laber, PhD Assistant Professor Department of Statistics North Carolina State University
Abstract:Dynamic treatment regimes are of growing interest across the clinical sciences because these regimes provide one way to operationalize and thus inform sequential personalized clinical decision making. Formally, a dynamic treatment regime is a sequence of decision rules, one per stage of clinical intervention.Each decision rule maps up-to-date patient information to a recommended treatment.We review a critical inferential challenge that results from nonregularity, which often arise in inference for parameters in the optimal dynamic treatment regime.Nonregularity is associated with asymptotic distributions of estimators that are sensitive to local perturbations.We demonstrate that previous attempts to mitigate nonregularlity through shrinkage can be arbitrarily worse than no shrinkage at all.
We propose a locally consistent adaptive confidence interval for the parameters of the optimal dynamic treatment regime.We use data from the Adaptive Pharmacological and Behavioral Treatments for Children with ADHD Trial as an illustrative example.
"Addressing issues associated with evaluating prediction models for survival endpoints based on the concordance statistic"
Ming Yang, PhD Assistant Professor Division of Biostatistics and Bioinformatics Penn State University
Abstract: Prediction models for disease risk and prognosis play an important role in biomedical research, where evaluating their predictive accuracy in the presence of censored data is of substantial interest. The standard concordance (c) statistic has been extended to provide a summary measure of predictive accuracy for a models for survival outcomes. Motivated by a prostate cancer study, we address several issues associated with evaluating prediction models for survival outcomes based on c-statistic with a focus on estimators using the technique of inverse probability of censoring weighting (IPCW). Compared to the existing work, we provide the complete results on the asymptotic properties of the IPCW estimators under the assumption of coarsening at random (CAR) and propose a sensitivity analysis in the case of noncoarsening at random (NCAR). In addition, we extend the IPCW approach as well as the sensitivity analysis to the setting of high-dimensional data. We apply the proposed approaches to assess predictive accuracy of prediction models for cancer recurrence after prostatectomy, and show that the estimated predictive accuracy for all models of interest is sensitive to the NCAR assumption but the model with best predictive accuracy is not. We further evaluate the performance of the proposed methods in both low-dimensional data and high-dimensional data settings through simulations.
"Generalizing Quntile Regression for Counting Processes with Applications to Recurrent Events"
Abstract: In survival analysis, quantile reqgression has become a useful approach to accounting for covariate effects on the distribution of a single event time. In this work, we discusss how quantile regression can be extneded to model counting processes that are naturally embedded in event history data, which leads to a broader regression framework for survival data. We specifically investigate the proposed modeling of couting processes in recurrent events settings. We show that the new counting process model facilitates the accommodation of complex observation windows of recurrecnt events as often encountered in observational studies. It also enables a unified theory and inferential framework for studying both censored quantile regression and the proposed recurrent events model. As another useful contribution of this work, we propose a sample-based covariance estimation procedure, which provides a useful inference tool that complements the prevailing boostrapping approach. We demonstrate the utility of our proposals via simulation studies and an application to a dataset from the US Cystic Fibrosis Foundation Patient Registry (CFFPR).
Limin Peng, PhD Associate Professor Division of Biostatistics and Bioinformatics Emory University
"ATA Guidelines 2014: Use of Neck Ultrasound to Guide Fine-Needle Aspiration Decision Making"
Susan J. Mandel, MD, MPH - Professor of Medicine and Radiology Date: Wednesday, September 10, 2014 Time: 12:00 noon - 1:00 pm Location: 12th Floor - SCTR - Smilow Center for Translational Research 12-146
************************************************************** Educational Objectives: After completing this activity, participants should be able to:
·Apply the latest clinical guidelines in the management of endocrine diseases
·Evaluate the efficacy of therapeutic options in endocrine disorders
·Evaluate the initiation of new types of treatment and procedures
Accreditation The Perelman School of Medicine at the University of Pennsylvania is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education to physicians
Designation of Credit The Perelman School of Medicine at the University of Pennsylvania designates this live activity for a maximum of 1 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
** Will be giving Tom Moshang lecture at CHOP Pediatric Grand Rounds at 8AM on 10/1/14
"Endothelial Dysfunction Biomarkers and Preterm Delivery: A Case-Control Study to Examine Association of Preterm Delivery and Pathogenic Precursor of CVD"
Xinhua Chen, MD, MS
Department of Obstetrics and Gynecology, Rowan University-SOM
"Including Brain Disorders in Global Health Epidemiology: Current Challenges"
Farrah Mateen, MD, PhD
Adjunct Professor, Department of Neurology, Harvard Medical School
Icahn School of Medicine at Mount Sinai “Long-term survival of influenza A virus infected cells and effects on pathogenesis”
209 Johnson Pavilion
Duke University School of Medicine “Temporal dynamics of primary B-cell infection dictates EBV transformation”
BRB Auditorium, BRB II/III
University of Southern California Keck School of Medicine “Host-Pathogen Standoff: Linear Ubiquitination and Inflammation”
Austrian Auditorium, CRB
Howard Hughes Medical Institute and Tufts University School of Medicine “A Vibrio cholerae/Phage Battle in the Context of Human Infection”
Austrian Auditorium, CRB
Translational Lung Biology and Precision Medicine Friday, September 19, 2014; 8:00 AM - 4:00 PM Smilow Auditorium and Commons
Keynote Speech by: Mark Gladwin, MD Division Chief, Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh
Hosted by The Center for Translational Lung Biology
Department of Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore MD "Immune Tolerance in Reconstructive Transplantation: The Holy Grail or an Attainable Goal?"
CTRB 1200 B
Ram Dixit, Ph.D.
Washington University in St. Louis
"Life inside a box: how the microtubule cytoskeleton contributes to plant cell shape”
2pm CRB Austrian Auditorium
R. John Solaro, Ph.D.
University of Illinois at Chicago
"Integration of Sarcomere Signaling in Cardiac Function"
2pm Austrian Auditorium
PENNSYLVANIA MUSCLE INSTITUTE SEMINAR- James Ervasti, PhD "Integration of Sarcomere Signaling in Cardiac Function" 2pm Austrian Auditorium
John Cooper, MD, PhD - Professor of Cell Biology and Physiology, Professor and Interim Head of Biochemistry and Molecular Biophysics, Washington University in St. Louis, "Capping Protein, CARMILs and Actin Assembly at Membranes"
2pm, Austrian Auditorium.
PMI Muscle Club
Benjamin L. Prosser, Ph.D.
"Beat-to-beat mechano-signaling in the heart”
1pm in 702CRB
1pm 702 CRB
Assistant Professor Microbiology
Perelman School of Medicine
"Innate immune detection of intracellular bacterial pathogens"
123C Abramson Research Center
Margaret Chou, PhD Children's Hospital of Philadelphia Pathogenic mechanisms of pediatric neoplams: insights into TRE17/ubiquitin-specific protease-6 (USP6)
Ralph Deberardinis, MD, PhD UT Soutwestern Medical Center Cancer Metabolism – Basic Biology and Translational Opportunities
Martin Chalfie, PhD Columbia University Transduction and Modulation of Touch Sensitivity in C. elegans
David H. Ledbetter, PhD, FACMG
Executive Vice President Chief Scientific Officer
Geisinger Health System
Sequencing 100,000 patients in the Geisinger Learning Healthcare Laboratory
Risa Lavizzo-Mourey, MD, MBA, Robert Wood Johnson Foundation president and CEO
Sandra Brooks, MD, MBA
"Statistical Analysis of High Throughput Sequencing Data with Mouse Collaborative Crosses"
Fei Zou, PhD Professor Department of Statistics Univeristy of North Carolina
Abstract: For decades, the mouse has been the most popular surrogate model for humans. In this talk, we will first introduce a new and superior mouse model, the Collaborative Cross (CC). The CC is a large panel of inbred mouse strains currently being developed at UNC through a community effort for modeling the heterogeneous human population.We will then discuss some statistical challenges and solutions associated with high throughput next generation sequencing data for assessing allelic imbalance (AI) in gene expression and DNA methylation, with F1 reciprocal mice derived from the CC founder or CC RI strains.The non-random X-chromosome in-activation will be demonstrated by a real mouse data. Models accounting for such chromosome-wide in-activation, allowing proper analysis of chromosome X expression will be discussed.
Function and biogenesis of U1 snRNP: an overarching mRNA regulator
Professor, Department of Genetics University of Georgia "Too much is not enough: Foxn1 dosage and function in fetal and adult thymic epithelial cells"
Austrian Auditorium, CRB
Chief, Laboratory of Systems Biology and Lymphocyte Biology Section National Institute of Allergy and Infectious Diseases, National Institutes of Health “Using advanced dynamic and multiplex static imaging to probe innate and adaptive immunity in vivo”
Austrian Auditorium, CRB
Professor Departments of Medicine, Molecular Microbiology, Pathology & Immunology Head, Division of Infectious Diseases and Vaccine Development Center for Human Immunology & Immunotherapy Programs Washington University School of Medicine “Immunity to Viral Pathogens: Starting at the Lymph Node and Ending in the Brain”
Austrian Auditorium, CRB
Stefan Weber, Ph.D. (Albert-Ludwigs University of Freiburg), "Exploiting advanced EPR and NMR to study reactive intermediates in flavoprotein function"
Walter Schroeder Professor and Chairman
Department of Microbiology & Molecular Genetics
Associate Director for Basic Research, Cancer Center
Medical College of Wisconsin
"An Update on the Choreography of the Vaccinia Virus Life Cycle”
Professor of Pathology/Molecular Microbiology & Immunology
Head, Division of Pathobiology & Immunology
Vaccine & Gene Therapy Institute
Oregon Health & Science University School of Medicine
“Bench to Bedside: Clinical Development of Cytomegalovirus Vectors”
Join us as we unlock imagination in the service of health and medicine.
Friday, September 12th
Location: 701 Blockley Hall
“Turn it Upside Down” – 9:15am-10:55am
This session introduces surprising insights that flip beliefs, question standard operating procedures, discard some closely held assumptions and lead to fresh insights about health and medicine.
“Stealing Smart” – 11:00am-12:40pm
This session demonstrates how some of the best solutions to problems in health and medicine come from other worlds than the domain where the problem originated or is usually addressed.
A Vision to Build a Culture of Health
What: Dr. Risa Lavizzo-Mourey, President and CEO of Robert Wood Johnson Foundation
When: Friday, September 19th 2014 (12:00-1:30pm)
Where: Houston Hall, Bodek Lounge: Lunch reception following lecture in the adjacent Reading Room
Risa Lavizzo-Mourey, MD, MBA is president and CEO of the Robert Wood Johnson Foundation, a position she has held since 2003. The Robert Wood Johnson Foundation is the nation’s largest philanthropy dedicated solely to health and health care.
With more than 30 years of personal experience as a medical practitioner, policy-maker, professor and nonprofit executive, Lavizzo-Mourey has built on the Foundation’s 40-year history of addressing key health issues by adopting bold, forward-looking priorities that include:
Building a Culture of Health for all Americans.
Reversing the childhood obesity epidemic.
Creating a health care system that provides the best possible care at a reasonable cost.
Expanding the role of highly trained nurses.
Convincing government, business, and civic leaders to consider the public’s health when making decisions.
Addressing the social factors that impact health, especially among the most vulnerable.
Ensuring that all Americans have access to stable and affordable health care coverage.
Supporting a new generation of health leaders.
A specialist in geriatrics, Lavizzo-Mourey came to the Foundation from the University of Pennsylvania, where she served as the Sylvan Eisman Professor of Medicine and Health Care Systems. She also directed Penn’s Institute on Aging and was chief of geriatric medicine at the University of Pennsylvania’s School of Medicine. She served as deputy administrator of what is now the Agency for Health Care Research and Quality and worked on the White House Health Care Reform Task Force, co-chairing the working group on Quality of Care. She also has served on the Task Force on Aging Research, the National Committee for Vital and Health Statistics and the President’s Advisory Commission on Consumer Protection and Quality in the Health Care Industry.
A graduate of the University of Washington and the State University of New York at Stony Brook, Lavizzo-Mourey earned her medical degree from Harvard Medical School. She also holds an MBA from the Wharton School at the University of Pennsylvania. Lavizzo-Mourey is a member of the Institute of Medicine of the National Academy of Sciences and the President’s Council for Fitness, Sports and Nutrition. She serves on the Smithsonian Board of Regents and several other boards of directors.
She and her husband of nearly 40 years have two adult children and one grandchild.
"The Meaning of a Superfund Site to the Community"
Location: 10-100 Smilow Center for Translational Research
Join Frances Barg, PhD, Associate Professor of Family Medicine and Community Health and Edward Emmett, MD, MS, Professor of Occupational & Environmental Medicine as they speak about Superfund sites at the Penn SRP Center/CEET seminar series.
"The War on Poverty at 50: Its History and Legacy" (Conference)
Location: Amado Recital Hall, Irvine Auditorium (1st floor)
Attend this FREE conference, which will bring together leading scholars and policy analysts. The event is cosponsored by the Penn School of Social Policy & Practice, Urban Studies at Penn, the Penn Department of History, and Penn Institute for Urban Research.
CPHI Seminar Series: "From Disease to Health: Population Based Experience of a Major Community Health System" with Sandra Brooks, MD, MBA
October 2, 2014
Trauma Module: Traumatic Brain Injury (TBI)
Douglas H. Smith, MD The Robert. A Groff Professor of Neurosurgery Vice Chairman for Research and Education Director, Penn Center for Brain Injury and Repair Department of Neurosurgery Perelman School of Medicine at the University of Pennsylvania
Towards Better Adolescent HIV Treatment Adherence
Elizabeth Lowenthal, MD, MSCE,
Assistant Professor of Pediatrics Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine
Interim and Chair of Microbiology
Perelman School of Medicine
"Genetic approaches to studying host-virus interactions"
Austrian Auditorium, CRB
This event is hosted by BPP and CHOP and brings guest speakers: Dr. Randall K. Ribaudo and Dr. Larry Petcovic from SciPhD to talk about how to prepare yourself for an exciting career in industry.
Johnson & Johnson Scientists Sheri Moores, Ph.D. and Kate Sasser, Ph.D. will be here to discuss their perspectives on careers in industry.
All BPP Postdocs are invited to attend this Ice Cream Social in BRB Lobby as BPP and the Penn community say, "Thank you!" and acknowledge the hard work you do!
12pm in 702 Clinical Research Building
Faculty Meeting 1-2pm following chart rounds in PCAM 4 board room
"Safe and Active Transportation: Conjoint Approaches to Promoting Health and Preventing Road Injury"
Alexander Quistberg, PhD, MPH
University of Washington, School of Medicine
James Galbraith, MD, "HIV High Yield & Impact of Emergency Department Routine HIV/HCV Screening"
Teach-In: Ebola and Global Health
* The Center for African Studies * The Global Health Initiative
* The Center for Global Studies * The University YMCA
The Center for Global Studies is a National Resource Center with funding from the U.S. Department of Education.
When: Thursday, September 18, 4pm - 5:30pm
Where: Lincoln Hall - Room 1092
Dr. Gay Miller - Professor in the Department of Veterinary Pathobiology
Dr. Barry Pittendrigh - Professor in the Department of Entomology and Director of Scientific Animations Without Borders (SAWBO)
Christian Martyn Kamara - National General Secretary (NGS) and Chief Executive Officer of the YMCA in Sierra Leone
Mabinty Tarawallie, MSW – Recent Graduate from the University of Illinois School of Social Work and Sierra Leone national