Olga Boudker, Ph.D. (Weill Cornell Medical College), "Transport dynamics of the glutamate transporter"
Rodebaugh Diabetes Center Conference Series Presents:
Topic: Communication in T2DM
Speaker: Serena Cardillo / Kim Olsen
Department of Radiation Oncology
Division of Radiation Biology Research Seminar Series
Christopher Willey, M.D., Ph.D.Associate Professor of Radiation OncologyUniversity of AlabamaHazelrig-Salter Radiation Oncology Center "TBD"
12pm-1pm in Room 10-146AB;
Lunch will be served at 11:45am
"The role of caspase-8 in regulating TLR-dependent cytokine production"
The uses and misuses of meta-analyses and the nuts, bolts and infrastructure to make them happen
Kay Dickerson, MA, PhD
Johns Hopkins Bloomberg School of Public Health
The workshop will be presented by Shelly, Fehr the Director of the OCR IND/IDE Support Unit.
This presentation provides an overview of the Investigational New Drug (IND) regulations, guidelines, content, and Sponsor responsibilities.
• IND and Drug terms
• Applicable regulations and guidance
• When an IND is required
• Sponsor & Investigator responsibilities
• Contents and submission process for an IND Application
• IND management activities
Come hear speakers from OHRP, AAHRPP, NIH, and our co-host Institutions!
OHRP Research Community Forum:
Moving Beyond the Basics of Informed Consent, Philadelphia, PAOctober 23rd and 24th, 2014.
The Office for Human Research Protections (OHRP) is co-sponsoring a Research Community Forum (RCF) with local institutions in Philadelphia, PA on Thursday and Friday, October 23rd and 24th, 2014 entitled 'Moving Beyond the Basics of Informed Consent'. Changes in the research environment, technological advances, and agreater understanding of related ethical concerns have made the issueof informed consent in research increasingly complex. This RCF will examine consent related challenges faced by IRBs, investigators, and other members of the research community. The conference will foster thought provoking topics and stimulating discussions, and provide creative solutions to these challenges.
This dynamic two-day event will be co-hosted by the Children1s Hospital of Philadelphia, the University of Pennsylvania, Drexel University, Temple University, Thomas Jefferson University, and the Wills Eye Hospital. The conference will be held at the Sheraton Philadelphia Society Hill Hotel at 1 Dock St., Philadelphia, PA 19106 in the Old City section of Philadelphia.
Multiple sequence alignment of datasets containing many thousands of sequences is a challenging problem with applications in phylogeny estimation, protein structure and function prediction, taxon identification of metagenomic data, etc. However, few methods can analyze large datasets, and none have been shown to have good accuracy on datasets with more than about 10,000 sequences, especially if the sequence datasets have evolved with high rates of evolution.
In this talk, I will present a new method to obtain highly accurate estimations of large-scale multiple sequence alignments and phylogenies. The basic idea is to use an ensemble of Hidden Markov Models (HMMs) to represent a "seed alignment", and then align all the remaining sequences to the seed alignment. Our method, UPP, returns very accurate alignments, and trees on these alignments are also very accurate - even on datasets with as many as 1,000,000 sequences, or datasets that contain many fragmentary sequences. Furthermore, UPP is both fast and very scalable, so that the analysis of the 1-million taxon dataset took only 24 hours using 12 cores and small amounts of memory. Finally, this Ensemble of HMMs technique improves the accuracy of methods for other bioinformatics problems, including phylogenetic placement and taxon identication of metagenomic data.
Tandy Warnow is the Founder Professor of Bioengineering and Computer Science at the University of Illinois at Urbana-Champaign. Her research combines mathematics, computer science, and statistics to develop improved models and algorithms for reconstructing complex and large-scale evolutionary histories in both biology and historical linguistics. Tandy received her PhD in Mathematics at UC Berkeley under the direction of Gene Lawler, and did postdoctoral training with Simon Tavare and Michael Waterman at USC. She received the National Science Foundation Young Investigator Award in 1994, the David and Lucile Packard Foundation Award in Science and Engineering in 1996, a Radcliffe Institute Fellowship in 2006, and a Guggenheim Foundation Fellowship for 2011. Her current research focuses on phylogeny and alignment estimation for very large datasets (10,000 to 1,000,000 sequences), estimating species trees and phylogenetic networks from collections of gene trees, and metagenomics.
Rebroadcast of Karam C. Mounzer, MD "Winning The War against HCV: The Unattainable Cure?"