School of Medicine Calendar - ALL
All School of Medicine events for staff (does not include Student events) - ( Details and Feeds
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September 18, 2012
Research seminars will resume in the fall
Len A. Pennacchio, PhD
Doe Joint Genome Institute
"Beyond Exomes: Noncoding In Vivo Function and Human Disease"
The Institute for Diabetes, Obesity, and Metabolism; the Division of Endocrinology, Diabetes, and Metabolism; and the Diabetes Research Center Combined Spring 2012 Seminar Series presents:
Casim A. Sarkar, Ph.D.
University of Pennsylvania
September 18, 2012
4:00 PM
Translational Research Center - 12-146
Professor
Department of Microbiology and Immunology
Harvard Medical School
“Treg control of non-immunological processes”
Austrian Auditorium
Wei Pan, Ph.D.
Professor, Division of Biostatistics
School of Public Health, University of Minnesota
Title: A network-based penalized regression method with application to genomic data
Abstract: Penalized regression approaches are attractive in dealing with high-dimensional data such as arising in high-throughput genomic studies. New methods have been introduced to utilize the network structure of predictors, e.g. gene networks, to improve parameter estimation and variable selection (Li and Li 2008, 2010; Pan 2009; Pan {it et al.} 2010). All the existing network-based penalized methods are based on an assumption that parameters, e.g. regression coefficients, of neighboring nodes in a network are close in magnitude, which however may not hold. In this paper we propose a novel penalized regression method based on a weaker prior assumption that the parameters of neighboring nodes in a network are likely to be zero (or non-zero) at the same time, regardless of their specific magnitudes. We propose a novel non-convex penalty function to incorporate this prior, and an algorithm based on difference convex programming. We use simulated data and a gene expression dataset to demonstrate the advantages of the proposed method over some existing methods. This is based on joint work with Sunny Kim and Xiaotong Shen.
This lecture is a part of the Fall 2012 Public Health 519 course "Issues in Global Health." If you would like to attend as a guest, please contact Dustin Utt (uttd@upenn.edu) to see if there is room available.
Information about the course: PUBH519 presents an overview of issues in global health from the viewpoint of many different disciplines, with emphasis on economically less developed countries. Themes include the state of the planet, including populations, resources, and environment; determinants of global health, ethical perspectives, challenges in communicable and non-communicable disease, and intervention strategies. If you are interested in registering for the entire course, please follow the protocol used in your home school. This is usually accomplished by checking with the home school program coordinator or advisor. Medical students should contact Helene Weinberg.
This lecture is a part of the Fall 2012 Public Health 519 course "Issues in Global Health." If you would like to attend as a guest, please contact Dustin Utt (uttd@upenn.edu) to see if there is room available.
Information about the course: PUBH519 presents an overview of issues in global health from the viewpoint of many different disciplines, with emphasis on economically less developed countries. Themes include the state of the planet, including populations, resources, and environment; determinants of global health, ethical perspectives, challenges in communicable and non-communicable disease, and intervention strategies. If you are interested in registering for the entire course, please follow the protocol used in your home school. This is usually accomplished by checking with the home school program coordinator or advisor. Medical students should contact Helene Weinberg.