Time: 12:00 PM Location: 251 BRB II/III
Ronald S. Gibbs, M.D.
Professor, Department of Obstetrics and Gynecology
Associate Dean for Continuing Medical Education and Professional Development
University of Colorado School of Medicine
Obstetrical Precursors of Early Neonatal Sepsis
Department of Radiation Oncology
Division of Radiation Biology Research Seminar Series
Joseph Deasy, Ph.D.
Chair, Department of Medical PhysicsEnid A. Haupt Endowed Chair in Medical Physics,Memorial Sloan Kettering Cancer Center
"Predicting the outcomes of radiotherapy using dose-volume and imaging metrics"
Speakers: Katelyn Miller (Rall lab), 2nd year PhD student
Megan Kissig (Seale Lab), 3rd year PhD student
Speaker: Raymond Penn Affiliation: Thomas Jefferson University, School of Medicine, Director, Center for Translational Medicine, Director of Pulmonary Research, Jefferson - Jane and Leonard Korman Lung Center
Endocrine Journal Club
Kyle Conference Room PCAM 4 West Pavilion
Attendings: Nasreen Alfaris and Jeremy Flood
Fellow: Shivani Agarwal
Michael E. Thase, MD Professor of Psychiatry Director, Mood and Anxiety Disorders Treatment and Research Program Department of Psychiatry University of Pennsylvania Perelman School of Medicine Location: BRB II/III Auditorium
Gary Wu - Ileus & pseudo-obstruction
Yael Mosse, PhD - ALK inhibition strategies to improve the outcome for patients with neuroblastoma
Tamar Taddei, MD - Hepatocellular Carcinoma: Diagnosis, Staging and General Management Approaches
PLEASE NOTE DR. MAYA CAPELSON'S SEMINAR IS CANCELED
Dr. Rugang Zhang's seminar title: "Metabolic reprogramming couples replication stress to oncogene-induced senescence"
2014 Bernard Cohen Memorial Lecture in Genetics
Michael S. Levine, Ph.D. Professor of Genetics University of California Berkeley
"Transcriptional precision in the Drosophila embryo and the evolutionary origins of vertebrate neural crest and cranial placodes in the Ciona tadpole"
Monday, April 21, 2014, 4:00 PM Main Auditorium, Biomedical Research Building
Dr. Michael S. Levine has been Professor of Genetics at UC Berkeley since 1996 and Chairman of the Chancellor’s Advisory Council for Biology since 2012. He was Head of the Division of Genetics, Genomics and Development from 2007-2011 and served as Acting Director of the Functional Genomics Program at the Joint Genome Institute (DOE) in 2001. Prior to that Dr. Levine held faculty positions at Columbia University and UCSD, and was a Visiting Professor of Zoology at the University of Zurich from 1999-2000.
Dr. Levine obtained a BA in Genetics from UC Berkeley in 1976, a PhD in Biophysics & Biochemistry from Yale in 1981, and did brief postdoc stints in Basel Switzerland and UC Berkeley before starting his own lab at Columbia. He was elected to the American Academy of Arts and Science in 1996 and the National Academy of Sciences in 1998. He received the Molecular Biology Award from the National Academy of Sciences in 1996 and the Wilbur Cross Medal from Yale University in 2009.
The Levine lab studies the mechanisms responsible for switching genes on and off in the early Drosophila embryo. These studies led to the characterization of the eve stripe 2 enhancer, short-range repression, and the regulation of long-range enhancer-promoter interactions. Dr. Levine’s most recent studies focus on the visualization of gene activation in living embryos. In addition, he uses the tadpole of a simple chordate, Ciona intestinalis, to explore the evolutionary origins of key vertebrate innovations such as the multi-chambered heart and head sensory organs.
Manuel Garber, Ph.D.
University of Massachusetts
An evolutionary history of long non coding RNAs
Manuel Garber - University of Massachusetts
Talk title: An Evolutionary History of Long Non Coding RNAs
Sue Biggins, Ph.D. (Fred Hutchinson Cancer Research Center), "Reconstituting kinetochore functions in vitro"
"A Constrained Mixed Effects Model Based on Semilinear Differential Equation for Cell Polarity Signaling in Tip Growth of Pollen Tubes"
Xingping Cui Associate Professor Department of Statistics University of California, Riverside
Abstract:The key of tip growth in eukaryotes is the polarized distribution on plasma membrane of a particle named ROP1. This distribution is the result of a positive feedback loop, whose mechanism can be described by a Differential Equation parametrized by two meaningful parameters kpf and knf . In this paper, we introduce a mechanistic Integro-Differential Equation (IDE) derived from a spatiotemporal model of cell polarity and we show how this model can be fitted to real data i.e ROP1 intensities measured on pollen tubes. At first, we provide an existence and uniqueness result for the solution of our IDE model under certain conditions. Quite interestingly, this analysis gives a tractable expression for the likelihood, and our approach can be seen as the estimation of a constrained nonlinear model. Moreover, we introduce a population variability by introducing a constrained nonlinear mixed model. We then proposed a constrained Least Squares method to fit the model under single subject case, and two methods, constrained Methods of Moments and constrained Restricted Maximum Likelihood (REML) to fit the model under the multiple subjects case. The performances of all the three methods are studied in a simulation example and are used on a real multiple subjects dataset.
April 25, 2014 Akiva S. Cohen, PhD Pediatrics/Neurology "Alterations in Brain Circuitry That Underlie Cognitive Impairment Caused by Brain Injury"
Rodebaugh Diabetes Center Conference Series Presents:
Topic: Dermatology & Endocrinology
Speaker: Misha Rosenbach
Botswana 2.0: Exploring New Areas of Collaboration and Discovery
Wednesday, April 23, 2014 from 8:30 AM to 12:30 PM (EDT) Philadelphia, PA https://www.eventbrite.com/e/botswana-20-exploring-new-areas-of-collaboration-and-discovery-tickets-10170870347
Hosted by the Botswana-UPenn Partnership and funded in part by the University of Pennsylvania's Provost's Interdisciplinary Seminar Fund and Global Engagement Fund, this half-day symposium on Penn's campus aims to explore areas of potential collaboration between Penn and Botswana beyond healthcare.
The event is free and open to the entire Penn community. If you plan to attend any part of the symposium, please REGISTER above! (no need to print a ticket)
Keynote speakers include:
Prof. Otlogetswe Totolo; University of Botswana’s new Provost (DVC of Academic Affairs)
Dr. Jeff Ramsay; current spokesperson for Botswana President Khama, and a Penn SAS alumnus
Other speakers include:
Harvey Friedman, Director of the BUP
Doreen Ramogola-Masire, In-country Director of the BUP
Kenneth Shropshire, Director of the Wharton Sports Business Initiative
Joseph Powers, Managing Director of Global Partnerships and Social Impact
Hans-Peter Kohler, Demography, Dept of Sociology
Harris Steinberg, City and Regional Planning, PennDesign
Robert Gross, Professor of Medicine, Infectious Diseases
A symposium agenda will be available soon.
The Institute for Diabetes, Obesity, and Metabolism; the Division of Endocrinology, Diabetes, and Metabolism; and the Diabetes Research Center Combined Spring 2014 Seminar Series presents:
Lina M. Obeid, M.D.
Stony Brook School of Medicine
“Bioactive Sphingolipids in Inflammation and Cancer”
April 22, 2014
Smilow Center for Translational Research, 12th Floor
Dissertation title: Role of Ceramide Kinase in Breast Cancer Progression
Location: Smilow 9-146
Mentor: Dr. Shelley Berger
Lecture title: “Circadian Regulation of Intestinal Immunity”.
Dr. Hooper is Professor at UT Southwestern Medical Center.
Grossman Auditorium, The Wistar Institute
"Application of Physics to Biological Problems"
Financing Development and Innovation in Africa ******************************** Institute for African Development presents this symposium at Cornell University this spring. This event is co-sponsored by the African Development Bank and Mario Einaudi Center for International Studies and is open to the public. For more information see: http://iad.einaudi.cornell.edu/.
WHERE: Cornell University, Ithaca, NY WHEN:April 25-26, 2014
“Semi-parametric regression models for longitudinal data with outcome-dependent observation times”
Kay See Tan, MS
PhD Candidate Division of Biostatistics Department of Biostatistics and Epidemiology
Advisors: Andrea B. Troxel, ScD and Benjamin C. French, PhD Committee Chair: Sarah J. Ratcliffe, PhD Committee: Dylan Small, PhD and Kevin G. Volpp, MD, PhD
Abstract:Conventional longitudinal data analysis methods typically assume that outcomes are independent of the data-collection schedule. However, the independence assumption may be violated when an event triggers outcome assessment in between prescheduled follow-up visits. For example, patients initiating warfarin therapy who experience poor anticoagulation control may have extra physician visits to monitor the impact of necessary dose changes. Observation times may therefore be associated with outcome values, which may introduce bias when estimating the effect of covariates on outcomes using standard longitudinal regression methods. We consider a joint model approach with two components: a semi-parametric regression model for longitudinal outcomes and a recurrent event model for observation times. The semi-parametric model includes a parametric specification for covariate effects, but allows the effect of time to be unspecified. We formulate a framework of outcome-observation dependence mechanisms to describe conditional independence between the outcome and observation-time processes given observed covariates or shared latent variables.
We generalize existing methods for continuous outcomes by accommodating any combination of mechanisms through the use of observation-level weights and/or patient-level latent variables. We develop new methods for binary outcomes, while retaining the flexibility of a semi-parametric approach. We extend these methods to account for discontinuous risk intervals in which patients enter and leave the at-risk set multiple times during the study. Our methods are based on counting process approaches, rather than relying on possibly intractable likelihood-based or pseudo-likelihood-based approaches, and provide marginal, population-level inference. In simulations, we evaluate the statistical properties of our proposed methods. Comparisons are made to ‘naïve’ approaches that do not account for outcome-dependent observation times. We illustrate the utility of our proposed methods using data from a randomized trial of interventions designed to improve adherence to warfarin therapy and a randomized trial of malaria vaccines among children in Mali.
Ed Ballister "Inducible protein dimerization:: new tools and applications to understanding the mitotic checkpoint", (advisor: Mike Lampson, Ph.D.)
Viral Hepatitis Grand Rounds, TBD
UT Southwestern Medical Center
"Circadian Regulation of Intestinal Immunity"
Austrian Auditorium, CRB
The Endocrinology Grand Rounds Series presents:
"PCOS" Anuja Dokras, MD, PhD - Associate Professor of Obstetrics and Gynecology Date: Wednesday, April 23, 2014 Time: 12:00 noon - 1:00 pm Location: 12th Floor - SCTR - Smilow Center for Translational Research 12-146 ************************************************************** Educational Objectives: After completing this activity, participants should be able to: • Apply the latest clinical guidelines in the management of endocrine diseases • Evaluate and efficacy of therapeutic options in endocrine disorders • Describe the results of translational research as it pertains to endocrine diseases
Accreditation The Perelman School of Medicine at the University of Pennsylvania is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education to physicians
Designation of Credit The Perelman School of Medicine at the University of Pennsylvania designates this live activity for a maximum of 1 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
"The risk of breast and ovarian cancer among BRCA1/BRCA2 carriers with risk-reducing surgery"
Xinglei Chai MS Candidate Division of Biostatistics Department of Biostatistics and Epidemiology
Silke Hauf, M.D., Assistant Professor of Biological Sciences, Department of Biological Sciences, Virginia Polytechnic Institute and State University, "Nobody is perfect - fragility and slowness in mitotic checkpoint signaling" CRB Austrian Auditorium
Physiology presents its first "On the Road Seminar" with Carol Deutsch, Ph.D. "Ribosome-Peptide Pas de Deux: Tunnel Vision"
Faculty members from the Department of Phsyiology share the talks they take with them "on the road".
Preparing for the Academic Job Search
Wednesday, April 23, Part 1: 4:00-5:00pm; Part 2: 5:10-6:15pm
Cohen Hall, G16, Terrace Room
Career Services graduate student/postdoc advising staff will discuss the steps of the faculty job search. Benefit from the combined knowledge of all the graduate student/postdoc advisors working together to provide you with a solid foundation to start your academic/faculty job search, or to refresh your approach as you try again. This overview of the whole process will help you to identify what you will need to do to be prepared and successful, and when you can make the most use of the services and resources offered by Career Services.
4-5pm Preparing to Apply
· determining readiness to go on the market
· understanding the job market cycle and how search committees work
Q & A on these topics
· written materials for the job search
· identifying job opportunities
· the logistics of applying
Q & A on these topics
5:10-6:15pm Interviewing and Beyond
· preparing for interviews
· screening interviews
· campus interviews, including the job talk
Q & A on these topics
· negotiating and accepting offers
· preparing to start the job
· Plan B/what to do if you don’t get an offer
Q & A on these topics
This event is for current Penn postdocs, current/recent Penn doctoral students and MFA students interested in academic careers. If you plan to attend, please sign up and indicate if you will attend either or both sessions.
Besides responsible for overseeing public service media institutions and the chief communications coordinator for Government of Botswana, Dr. Ramsay is a noted authority of the history of Botswana. He has also written on African politics and media policy and was active as a Botswana based columnist, commentator and occasional news reporter before joining the public service. More at: http://www.linkedin.com/in/ramsaybotswana
The Ribosome: Structure and Function
RESEARCH SYMPOSIUM HONORING
2014 BENJAMIN FRANKLIN MEDAL LAUREATE
In the SMILLOW AUDITORIUM