Center for Cancer Research, NCI, National Institutes of Health
"Developing novel T cell-based immunotherapies for the treatment of metastatic cancer"
Grossman Auditorium, The Wistar Institute
"Moving and grooving of glutamate receptors"
Luigi Mastroianni Memorial Lecture
Time: 8:00am Location: Hirst Auditorium - 1st floor Dulles Building
Teresa K. Woodruff, Ph.D.
Thomas J. Watkins Professor of Obstetrics and Gynecology
Vice Chair, Research Obstetrics and Gynecology
Chief, Division of Reproductive Science in Medicine
Feinberg School of Medicine
Professor, Molecular Biosciences
Weinberg College of Arts, Northwestern University
Emerging Opportunities in Oncofertility Practice and Research
University of Calgary
Endocannabinoids: Gatekeeper of the Amygdala
Research Associate Professor Microbiology
Caleph Wilson, PhD:"TCR-pMHC Interactions: Have we been getting mixed signals?"
Class of '62, JMB
Nicholas E. Navin, P.D. (MD Anderson Cancer Center), "Investigating clonal diversity and evolution in breast cancer with single cell sequencing"
"Modeling & Simulation to Improve the Design of Clinical Trials"
Gary Rosner, ScD Professor and Director Division of Biostatistics and Bioinformatics Johns Hopkins University
Abstract: Clinical studies in cancer are becoming more complex, especially in early phase studies. The complexity arises because of many factors, such as the desire to be more efficient than in the past, the need to address endpoints other than tumor shrinkage with newer targeted agents, an interest in applying decision theoretic considerations to optimize the design, and the current interest in determining the best drugs for the specific molecular characteristics of each tumor. Many studies that incorporate Bayesian ideas in their design often require modeling and simulation to help determine the best design or to evaluate each study's operating characteristics. In this talk, I will discuss several examples of designs that benefitted from modeling and simulation.
Black Lab (Glennis Logsdon/Samantha Falk), "The CENP-A nucleosome, the proteoiins that bind to it, and the mechanisms of centromere establishment and maintenance"
Rodebaugh Diabetes Center Conference Series Presents:
Topic: Insulin Pump Introduction
Speaker: Shannon O'Brien
Seminar title: Tuberous Sclerosis and LAM from pathogenesis to therapy
Harvard School of Public Health “Mycobacterial bacilli - we're all individuals"
Austrian Auditorium, CRB
Matthew Hill, PhD University of Calgary Endocannabinoids: Gatekeeper of the Amygdala
The CENP-A nucleosome, the proteins that bind to it, and the mechanisms of centromere establishment and maintena
Cellular Biology and Viral Immunology Sections National Institute of Allergy and Infectious Diseases, National Institutes of Health “Translating Immunology: It's Not What You Think”
Austrian Auditorium, CRB
October 30, 2014
Robert L. Sadoff, MD Clinical Professor of Psychiatry Director, Forensic Fellowship Program Department of Psychiatry Perelman School of Medicine at the University of Pennsylvania
Department of Radiation Oncology
Division of Radiation Biology Research Seminar Series
Jonathan Lovell, Ph.D.Assistant Professor of Biomedical EngineeringUniversity at Buffalo, SUNY "Drug Delivery Using Porphyrin Nanovesicles."
12pm-1pm in Room 8-146AB;
Lunch will be served at 11:45am
Speaker: Glen Gaulton Affiliation:University of Pennsylvania Perelman School of Medicine, Executive Vice Dean and Chief Scientific officer
The Endocrinology Grand Rounds Series presents:
"Endocrine Clinical Cases"
Naji Alamuddin, MD and Jeffrey Kroopnick, MD - Endocrine Fellows Date: Wednesday, 0ctober 29, 2014 Time: 12:00 noon - 1:00 pm Location: 12th Floor - SCTR - Smilow Center for Translational Research 12-146
************************************************************** Educational Objectives: After completing this activity, participants should be able to:
·Apply the latest clinical guidelines in the management of endocrine diseases
·Evaluate the efficacy of therapeutic options in endocrine disorders
·Evaluate the initiation of new types of treatment and procedures
Accreditation The Perelman School of Medicine at the University of Pennsylvania is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education to physicians
Designation of Credit The Perelman School of Medicine at the University of Pennsylvania designates this live activity for a maximum of 1 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Location: 209 Johnson Pavilion
Advisor: Dr. Jeffrey Weiser
"Causal modeling under complex dependency in clustered and longitudinal observations"
Jiwei He, MS PhD Candidate Division of Biostatistics Department of Biostatistics and Epidemiology
Abstract: In assessing the efficacy of a time-varying treatment MarginalStructural Nested Mean Models (SNMMs) are useful in dealing with confounding by variables affected by earlier treatments. MSMs model the joint effect of treatments on the marginal mean of the potential outcome, whereas SNMMs model the joint effect of treatments on the mean of the potential outcome conditional on the treatment and covariate history. These models often consider independent subjects with noninformative time of observation.
We extend the two classes of models to clustered observations with time-varying treatments in the presence of time-varying confounding. We formulate models with both cluster- and unit-level treatments and derive semiparametric estimators of parameters in such models. For unit-level treatments, we consider both the presence and absence of interference, namely the effect of treatment on outcomes in other units of the same cluster. For MSMs, we show that the use of unit-specific inverse probability weights and certain working correlation structures can improve the efficiency of estimators under specified conditions. The properties of the estimators are evaluated through simulations and compared with the conventional GEE regression method for clustered outcomes. To illustrate our methods, we use data from the treatment arm of a glaucoma clinical trial to compare the effectiveness of two commonly used ocular hypertension medications.
We also extend SNMMs to situations with intermittent missing observations. In observational longitudinal studies, subjects often miss prescheduled visits intermittently. Previous literature has mainly focused on dealing with monotone censoring due to early dropout. Here we focus on intermittent missingness that can depend on the subjects' covariate and treatment history. We show that under certain assumptions the standard SNMMs can be used for situations where non-outcome covariates are missing intermittently. In situations where outcomes are also missing intermittently, we use a method that does not require artificially censoring the data, but requires a strict missing at random assumption. The estimators are shown to be consistent and achieve reasonable efficiency. We illustrate the method by estimating the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on genitourinary pain using data from a study of chronic pelvic pain.
Dissertation Advisor: Marshall Joffe, MD, MPH, PhD, Alisa Stephens, PhD Committee Chair: Russell Taki Shinohara, PhD Committee Members: John Kempen, MD, Linda Zhao, PhD
Arun Ramachandran, MD & Michael Blechner, MD
Aileen Love, MD & Vu Ho, MD
Location: 10-146 SCTR
Advisor: Dr. Michael Lampson
Location: Austrian Auditorium, CRB
Advisor: Dr. Gary Koretzky
Location: SCTR 10-146AB
Advisor: Dr. Ronald Collman
Associate Professor, Department of Microbiology and Immunology
School of Medicine and Biomedical Sciences State University of New York at Buffalo
Toxoplasma infections: it doesn’t take a PhD to grow a parasite
221 Hill Pavilion
“Temporal Dependencies with Time-Varying Exposures: Modelling Exposure-Lag-Response Associations”
Antonio Gasparrini, PhD
Imperial College London, UK
The workshop will be presented by Inna Strakovsky and Janine Poplais from the OCR IND/IDE Support Unit.
This presentation provides an overview of the Investigational Device Exemption (IDE) regulations, guidelines, content, and Sponsor responsibilities.
IDE and Device terms
Applicable regulations and guidance
When an IDE is required
Sponsor & Investigator responsibilities
Contents and submission process for an IDE Application
IDE management activities
Join us for this hands-on workshop on Monday, October 27th. Space is Limited - RSVPhere.
Bin Ren, M.D., Ph.D.
1 John Morgan Building (Seminar Room #13) Basement Level
October 31, 2014
12:15PM -1:30 PM
Ian Frank, MD, "The WHO HIV Treatment Guidelines"
Assistant Professor Microbiology
"Broadly reactive antibodies against the influenza virus surface glycoproteins: universal flu vaccines and beyond"
Grossman Auditorium, The Wistar Institute
THE EBOLA EPIDEMIC: PUBLIC HEALTH, HUMAN RIGHTS AND A COMMUNITY RESPONSE
Thursday, October 30, 2014
5:00 PM-7:30 PM
The Ebola Epidemic: Public Health, Human Rights and a Community Response
Thursday, October 30, 2014
5:00pm - 7:30pm
Nesbitt Hall, Stein Auditorium
3215 Market Street, Philadelphia, PA 19104
Please join us on Thursday, October 30 at 5:00pm in Nesbitt Hall for a 'teach-in' led by Drexel University School of Public Health faculty and our partners at the African Family Health Organization. We will be learning about the science, history and human rights implications of the Ebola epidemic and the community response at Drexel University, in Philadelphia and abroad.