|
People
News & Events
06.12.12
MJ Drake from MVP joins the lab to complete her PhD thesis!
06.11.12
Ben Dyer begins his summer rotation
05.23.12
Katy Haines' NPC1 paper is accepted!
05.14.12
Alexa Nicolas joins the lab to complete her undergraduate thesis!
04.13.12
MJ Drake & Rakesh Jambusaria presented at the 2012 BGSA Research Symposium
03.06.12
Luis Cocka presented at the 2012 CROI Research Symposium
Paul Bates, PhD
Rotation & Undergraduate Students
Alexa Nicolas (Undergraduate)
Ben Dyer (1st year MVP graduate student)
Graduate Students
Nathan H. Vande Burgt
 "My research focuses on interactions between the Ebolavirus Glycoprotein,
GP, and a cellular anti-viral protein, Tetherin. When enveloped viral
particles bud from the cell, Tetherin can retain these budded particles
on the cell surface and limit extracellular dissociation of virions. A
number of viruses have developed ways to overcome Tetherin mediated
restriction. Our lab has discovered that GP is the protein used by
Ebolavirus to counteract Tetherin. However, the mechanism used by GP is
not understood very well. Currently, I am using a number of molecular
biology methods to determine which domains of GP are required to
antagonize Tetherin. I am also interested in understanding how
Ebolavirus proteins may regulate or modify other cellular functions of
Tetherin."
Luis J. Cocka
 "Tetherin is an intrinsic antiviral factor shown to be important in
restricting viral egress. Additionally, tetherin has been shown to have a
poorly understood signaling function. I am interested in
understanding the mechanism by which tetherin signals and the
implications this function has during and independent of infection."
(Luis J. Cocka on Pubmed)
Sudil Mahendra
 "I am interested in the interaction of Ebola virus glycoprotein GP with
the host innate immune sensor Toll-like Receptor 4. I am currently
examining the significance of this interaction and its possible
contribution to Ebola virus uptake into host cells."
MJ Drake
Postdoctoral Fellows
Kathleen Haines
 "I am interested in studying the interactions between viruses and their hosts. My work specifically focuses on identifying host proteins that ebolavirus uses to enter cells."
(Kathleen Haines on Pubmed)
Kenneth Briley Jr
 "My research centers around the discovery of new viral entry factors. This work incorporates the use of genetic, biochemical , and
microscopic techniques to study particle uptake."
(Kenneth Briley Jr. on Pubmed)
Past Members
 2004
(left to right) Ken Thompson, Graham Simmons, Ning Chai, Arwen Vermeulen, Carlo
Tanzi, Sean Amberg, Paul Bates
 2003
(left to right) Sean Amberg, Paul Bates, Carlo Tanzi, Ning Chai, Indira
Akula, Liz Colston, Andy Peifer, Graham Simmons
 1997
(left to right) Lijun Rong, Kristin Gendron, Julie Huang, Rouven Wool-Lewis,
Yasmin Mir-Shekari, John Balliet, Rachel Damico, Joanne Crane, Paul Bates
 1995
(left to right) Yasmin Mir-Shekari, Rouven Wool-Lewis, Lijun Rong, Joanne
Crane, Paul Bates, Rachel Damico, John Balliet, Kristin Gendron
Dalek.htm
© The Trustees of
the University
of Pennsylvania
|
| 
