The Baur lab is interested in the basic mechanisms that lead to aging. Age is the most important risk factor for many of the diseases affecting Western society today, including cancer, cardiovascular disease, and neurodegenerative disorders. Slowing the aging process to improve health and longevity is possible, and can be experimentally demonstrated in rodents by decreasing energy intake in the absence of malnutrition (caloric restriction), drug-treatment, or genetic manipulation. However, opportunities to translate this knowledge into better human health have been severely limited by our poor understanding of the mechanisms involved. The long-term goal of our lab is to use models of lifespan extension, including CR, drugs, and longevity genes, to elucidate the basic mechanism(s) that drive aging in mammals, with the hope that this knowledge will lead to new therapeutic approaches to improve human health and longevity.
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