Selected Publications

Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science. 2012 Mar 30;335(6076):1638-43. Abstract | Reprint | Full Text

Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K., Shin Y-K, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martin-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, and de Cabo R. SRT1720 improves survival and healthspan of obese mice. Sci. Rep. 1:70 (2011).

Baur Joseph A: Resveratrol, sirtuins, and the promise of a DR mimetic. Mechanisms of ageing and development 131(4): 261-9, Feb 2010.

Armour Sean M, Baur Joseph A, Hsieh Sherry N, Land-Bracha Abigail, Thomas Sheila M, Sinclair David A: Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy. Aging 1(6): 515-28, Jun 2009.

Lou Zhenjun, Wei Jun, Riethman Harold, Baur Joseph A, Voglauer Regina, Shay Jerry W, Wright Woodring E: Telomere length regulates ISG15 expression in human cells. Aging 1(7): 608-21, Jul 2009.

Pearson Kevin J, Baur Joseph A, Lewis Kaitlyn N, Peshkin Leonid, Price Nathan L, Labinskyy Nazar, Swindell William R, Kamara Davida, Minor Robin K, Perez Evelyn, Jamieson Hamish A, Zhang Yongqing, Dunn Stephen R, Sharma Kumar, Pleshko Nancy, Woollett Laura A, Csiszar Anna, Ikeno Yuji, Le Couteur David, Elliott Peter J, Becker Kevin G, Navas Placido, Ingram Donald K, Wolf Norman S, Ungvari Zoltan, Sinclair David A, de Cabo Rafael: Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell metabolism 8(2): 157-68, Aug 2008.

Yang Hongying, Yang Tianle, Baur Joseph A, Perez Evelyn, Matsui Takashi, Carmona Juan J, Lamming Dudley W, Souza-Pinto Nadja C, Bohr Vilhelm A, Rosenzweig Anthony, de Cabo Rafael, Sauve Anthony A, Sinclair David A: Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell 130(6): 1095-107, Sep 2007.

Kim Dohoon, Nguyen Minh Dang, Dobbin Matthew M, Fischer Andre, Sananbenesi Farahnaz, Rodgers Joseph T, Delalle Ivana, Baur Joseph A, Sui Guangchao, Armour Sean M, Puigserver Pere, Sinclair David A, Tsai Li-Huei: SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. The EMBO journal 26(13): 3169-79, Jul 2007.

Baur Joseph A, Pearson Kevin J, Price Nathan L, Jamieson Hamish A, Lerin Carles, Kalra Avash, Prabhu Vinayakumar V, Allard Joanne S, Lopez-Lluch Guillermo, Lewis Kaitlyn, Pistell Paul J, Poosala Suresh, Becker Kevin G, Boss Olivier, Gwinn Dana, Wang Mingyi, Ramaswamy Sharan, Fishbein Kenneth W, Spencer Richard G, Lakatta Edward G, Le Couteur David, Shaw Reuben J, Navas Placido, Puigserver Pere, Ingram Donald K, de Cabo Rafael, Sinclair David A: Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444(7117): 337-42, Nov 2006.

Baur JA., Sinclair DA.: Therapeutic potential of resveratrol: the in vivo evidence. Nature Reviews in Drug Discovery 5(6): 337-342, 2006.

Baur J A, Zou Y, Shay J W, Wright W E: Telomere position effect in human cells. Science (New York, N.Y.) 292(5524): 2075-7, Jun 2001.