Department of Psychiatry
Penn Behavioral Health

Neuropsychiatry Section

Neuropsychiatry Section

Monica E. Calkins, PhD

Monica Calkins Dr. Calkins is Associate Professor of Psychology in Psychiatry at the University of Pennsylvania Perelman School of Medicine. Her research program aims to identify and characterize psychophysiological and neurocognitive features associated with the neurodevelopment of psychotic disorders in young people. The overarching goal of this collaborative research program is to contribute to enhanced early identification of psychosis and increased understanding of its pathophysiological processes. As the Director of Clinical Research Assessment in the Neuropsychiatry Section, Dr. Calkins has led the conceptualization of assessment approaches, development, adaptation and implementation of instruments, training and supervision of assessors, establishment and maintenance of quality control procedures, and use and interpretation of clinical data. She has given numerous local, national and international lectures on topics including biobehavioral risk factors for psychosis, early identification of psychosis, psychopathology assessment, careers in psychology, and research ethics. Dr. Calkins involves and mentors students (undergraduate, graduate, medical, resident, post-doctoral) and research coordinators in research design, data collection, data analysis, and manuscript and thesis preparation. She has received early career awards from the International Congress on Schizophrenia Research and the American College of Neuropsychopharmacology, and a KO8 Mentored Clinical Scientist Award from the NIMH. Dr. Calkins has more than 90 publications in peer-reviewed journals. She is a member of the University of Pennsylvania Institutional Review Board, and has served as an ad-hoc reviewer for NIMH, several international grant review panels, and for more than 25 journals.

Education

  • 1991         B.A.     Temple University: Psychology Honors
  • 2002         Ph.D.  University of Minnesota: Clinical Science and Psychopathology Research
  • 2002-2004 NIMH Post-Doctoral Fellowship in Neuropsychiatry, Department of Psychiatry, University of Pennsylvania School of Medicine
  • 2002-2004 Scottish Rite Schizophrenia Research Fellowship, Department of Psychiatry, University of Pennsylvania School of Medicine


Academic Positions

2004-2015       Assistant Professor of Psychology in Psychiatry,
Perelman School of Medicine, University of Pennsylvania
2015-present Associate Professor of Psychology in Psychiatry at the Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine

Hospital and Administrative Appointments

2010 – Director of Clinical Research Assessment, Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania

2013 – Member, Institutional Review Board, University of Pennsylvania

Honors:

2015 National Alliance on Mental Illness Research Award: Recognizing Research Focused on First Episode Psychosis

2007-2012   Mentored Clinical Scientist Career Development Award (K08): National Institute of Mental Health

2008 Early Career Development Award: American College of Neuropsychopharmacology

2005 Young Investigator Award: International Congress on Schizophrenia Research

2002, 2000   Harrison Gough Research Travel Award, University of Minnesota, Department of Psychology

2001 Graduate Research Partnership Program Award, University of Minnesota Graduate School

2001 Doctoral Dissertation Supplemental Grant, University of Minnesota Graduate School

2000-2001 Doctoral Dissertation Fellowship, University of Minnesota Graduate School

1999-2000  Graduate Research Ethics Participant Grant, National Science Foundation and the Association for Practical and Professional Ethics

1996-1998   Neurobehavioral Aspects of Personality and Psychopathology Training Grant, National Institute of Mental Health, University of Minnesota

1994-1995 Department of Psychology Graduate Fellowship, University of Minnesota


Selected Publications:

Greenwood Tiffany A, Light Gregory A, Swerdlow Neal R, Calkins Monica E, Green Michael F, Gur Raquel E, Gur Ruben C, Lazzeroni Laura C, Nuechterlein Keith H, Olincy Ann, Radant Allen D, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Stone William S, Sugar Catherine A, Tsuang Debby W, Tsuang Ming T, Turetsky Bruce I, Freedman Robert, Braff David L (2015) Gating Deficit Heritability and Correlation With Increased Clinical Severity in Schizophrenia Patients With Positive Family History. The American journal of psychiatry Page: appiajp201515050605.


Gur Raquel E, March Mary, Calkins Monica E, Weittenhiller Lauren, Wolf Daniel H, Turetsky Bruce I, Gur Ruben C. (2015) Negative symptoms in youths with psychosis spectrum features: complementary scales in relation to neurocognitive performance and function. Schizophrenia research 166(1-3): 322-7.


Schmitt J Eric, Vandekar Simon, Yi James, Calkins Monica E, Ruparel Kosha, Roalf David R, Whinna Daneen, Souders Margaret C, Satterwaite Theodore D, Prabhakaran Karthik, McDonald-McGinn Donna M, Zackai Elaine H, Gur Ruben C, Emanuel Beverly S, Gur Raquel E (2015) Aberrant Cortical Morphometry in the 22q11.2 Deletion Syndrome. Biological psychiatry 78(2): 135-43.


Satterthwaite T D, Vandekar S N, Wolf D H, Bassett D S, Ruparel K, Shehzad Z, Craddock R C, Shinohara R T, Moore T M, Gennatas E D, Jackson C, Roalf D R, Milham M P, Calkins M E, Hakonarson H, Gur R C, Gur R E (2015) Connectome-wide network analysis of youth with Psychosis-Spectrum symptoms. Molecular psychiatry

Wolf Daniel H, Satterthwaite Theodore D, Calkins Monica E, Ruparel Kosha, Elliott Mark A, Hopson Ryan D, Jackson Chad T, Prabhakaran Karthik, Bilker Warren B, Hakonarson Hakon, Gur Ruben C, Gur Raquel E (2015) Functional neuroimaging abnormalities in youth with psychosis spectrum symptoms. JAMA psychiatry 72(5): 456-65.

Turetsky Bruce I, Dress Erich M, Braff David L, Calkins Monica E, Green Michael F, Greenwood Tiffany A, Gur Raquel E, Gur Ruben C, Lazzeroni Laura C, Nuechterlein Keith H, Radant Allen D, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Sprock Joyce, Stone William S, Sugar Catherine A, Swerdlow Neal R, Tsuang Debby W, Tsuang Ming T, Light Gregory (2015) The utility of P300 as a schizophrenia endophenotype and predictive biomarker: clinical and socio-demographic modulators in COGS-2. Schizophrenia research 163(1-3): 53-62.

Stone William S, Mesholam-Gately Raquelle I, Braff David L, Calkins Monica E, Freedman Robert, Green Michael F, Greenwood Tiffany A, Gur Raquel E, Gur Ruben C, Lazzeroni Laura C, Light Gregory A, Nuechterlein Keith H, Olincy Ann, Radant Allen D, Siever Larry J, Silverman Jeremy M, Sprock Joyce, Sugar Catherine A, Swerdlow Neal R, Tsuang Debby W, Tsuang Ming T, Turetsky Bruce I, Seidman Larry J: (2015) California Verbal Learning Test-II performance in schizophrenia as a function of ascertainment strategy: comparing the first and second phases of the Consortium on the Genetics of Schizophrenia (COGS). Schizophrenia research 163(1-3): 32-7.


Seidman Larry J, Hellemann Gerhard, Nuechterlein Keith H, Greenwood Tiffany A, Braff David L, Cadenhead Kristin S, Calkins Monica E, Freedman Robert, Gur Raquel E, Gur Ruben C, Lazzeroni Laura C, Light Gregory A, Olincy Ann, Radant Allen D, Siever Larry J, Silverman Jeremy M, Sprock Joyce, Stone William S, Sugar Catherine, Swerdlow Neal R, Tsuang Debby W, Tsuang Ming T, Turetsky Bruce I, Green Michael F (2015) Factor structure and heritability of endophenotypes in schizophrenia: findings from the Consortium on the Genetics of Schizophrenia (COGS-1). Schizophrenia research 163(1-3): 73-9.


Radant Allen D, Millard Steven P, Braff David L, Calkins Monica E, Dobie Dorcas J, Freedman Robert, Green Michael F, Greenwood Tiffany A, Gur Raquel E, Gur Ruben C, Lazzeroni Laura C, Light Gregory A, Meichle Sean P, Nuechterlein Keith H, Olincy Ann, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Stone William S, Swerdlow Neal R, Sugar Catherine A, Tsuang Ming T, Turetsky Bruce I, Tsuang Debby W (2015) Robust differences in antisaccade performance exist between COGS schizophrenia cases and controls regardless of recruitment strategies. Schizophrenia research 163(1-3): 47-52.

Nuechterlein Keith H, Green Michael F, Calkins Monica E, Greenwood Tiffany A, Gur Raquel E, Gur Ruben C, Lazzeroni Laura C, Light Gregory A, Radant Allen D, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Sprock Joyce, Stone William S, Sugar Catherine A, Swerdlow Neal R, Tsuang Debby W, Tsuang Ming T, Turetsky Bruce I, Braff David L (2015) Attention/vigilance in schizophrenia: performance results from a large multi-site study of the Consortium on the Genetics of Schizophrenia (COGS). Schizophrenia research 163(1-3): 38-46.

Merikangas Kathleen R, Calkins Monica E, Burstein Marcy, He Jian-Ping, Chiavacci Rosetta, Lateef Tarannum, Ruparel Kosha, Gur Ruben C, Lehner Thomas, Hakonarson Hakon, Gur Raquel E (2015) Comorbidity of physical and mental disorders in the neurodevelopmental genomics cohort study. Pediatrics 135(4): e927-38.

Light Gregory A, Swerdlow Neal R, Thomas Michael L, Calkins Monica E, Green Michael F, Greenwood Tiffany A, Gur Raquel E, Gur Ruben C, Lazzeroni Laura C, Nuechterlein Keith H, Pela Marlena, Radant Allen D, Seidman Larry J, Sharp Richard F, Siever Larry J, Silverman Jeremy M, Sprock Joyce, Stone William S, Sugar Catherine A, Tsuang Debby W, Tsuang Ming T, Braff David L, Turetsky Bruce I (2015) Validation of mismatch negativity and P3a for use in multi-site studies of schizophrenia: characterization of demographic, clinical, cognitive, and functional correlates in COGS-2. Schizophrenia research 163(1-3): 63-72.

Lee Junghee, Green Michael F, Calkins Monica E, Greenwood Tiffany A, Gur Raquel E, Gur Ruben C, Lazzeroni Laura C, Light Gregory A, Nuechterlein Keith H, Radant Allen D, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Sprock Joyce, Stone William S, Sugar Catherine A, Swerdlow Neal R, Tsuang Debby W, Tsuang Ming T, Turetsky Bruce I, Braff David L (2015) Verbal working memory in schizophrenia from the Consortium on the Genetics of Schizophrenia (COGS) study: the moderating role of smoking status and antipsychotic medications. Schizophrenia research 163(1-3): 24-31.

Gur Ruben C, Braff David L, Calkins Monica E, Dobie Dorcas J, Freedman Robert, Green Michael F, Greenwood Tiffany A, Lazzeroni Laura C, Light Gregory A, Nuechterlein Keith H, Olincy Ann, Radant Allen D, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Sprock Joyce, Stone William S, Sugar Catherine A, Swerdlow Neal R, Tsuang Debby W, Tsuang Ming T, Turetsky Bruce I, Gur Raquel E (2015) Neurocognitive performance in family-based and case-control studies of schizophrenia. Schizophrenia research 163(1-3): 17-23.

Calkins Monica E, Merikangas Kathleen R, Moore Tyler M, Burstein Marcy, Behr Meckenzie A, Satterthwaite Theodore D, Ruparel Kosha, Wolf Daniel H, Roalf David R, Mentch Frank D, Qiu Haijun, Chiavacci Rosetta, Connolly John J, Sleiman Patrick M A, Gur Ruben C, Hakonarson Hakon, Gur Raquel E (2015) The Philadelphia Neurodevelopmental Cohort: constructing a deep phenotyping collaborative. Journal of child psychology and psychiatry, and allied disciplines.


Satterthwaite Theodore D, Connolly John J, Ruparel Kosha, Calkins Monica E, Jackson Chad, Elliott Mark A, Roalf David R, Ryan Hopsona Karthik Prabhakaran, Behr Meckenzie, Qiu Haijun, Mentch Frank D, Chiavacci Rosetta, Sleiman Patrick M A, Gur Ruben C, Hakonarson Hakon, Gur Raquel E (2015) The Philadelphia Neurodevelopmental Cohort: A publicly available resource for the study of normal and abnormal brain development in youth. NeuroImage.


Light Gregory, Greenwood Tiffany A, Swerdlow Neal R, Calkins Monica E, Freedman Robert, Green Michael F, Gur Raquel E, Gur Ruben C, Lazzeroni Laura C, Nuechterlein Keith H, Olincy Ann, Radant Allen D, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Sprock Joyce, Stone William S, Sugar Catherine A, Tsuang Debby W, Tsuang Ming T, Turetsky Bruce I, Braff David L (2014) Comparison of the heritability of schizophrenia and endophenotypes in the COGS-1 family study. Schizophrenia bulletin 40(6): 1404-11.


Gur R E, Yi J J, McDonald-McGinn D M, Tang S X, Calkins M E, Whinna D, Souders M C, Savitt A, Zackai E H, Moberg P J, Emanuel B S, Gur R C (2014) Neurocognitive development in 22q11.2 deletion syndrome: comparison with youth having developmental delay and medical comorbidities. Molecular psychiatry 19(11): 1205-11.


Calkins Monica E, Moore Tyler M, Merikangas Kathleen R, Burstein Marcy, Satterthwaite Theodore D, Bilker Warren B, Ruparel Kosha, Chiavacci Rosetta, Wolf Daniel H, Mentch Frank, Qiu Haijun, Connolly John J, Sleiman Patrick A, Hakonarson Hakon, Gur Ruben C, Gur Raquel E (2014) The psychosis spectrum in a young U.S. community sample: findings from the Philadelphia Neurodevelopmental Cohort. World psychiatry : official journal of the World Psychiatric Association (WPA) 13(3): 296-305.


Tang Sunny X, Yi James J, Moore Tyler M, Calkins Monica E, Kohler Christian G, Whinna Daneen A, Souders Margaret C, Zackai Elaine H, McDonald-McGinn Donna M, Emanuel Beverly S, Bilker Warren B, Gur Ruben C, Gur Raquel E (2014) Subthreshold psychotic symptoms in 22q11.2 deletion syndrome. Journal of the American Academy of Child and Adolescent Psychiatry 53(9): 991-1000.e2.