Department of Psychiatry
Penn Behavioral Health

Neuropsychiatry Section

Neuropsychiatry Section

Raquel Gur, MD, PhD

Raquel GurDr. Gur is Professor of Psychiatry Neurology and Radiology at the University of Pennsylvania Perelman School of Medicine where she directs the Neuropsychiatry Section and the Schizophrenia Research Center and is Vice Chair of Research Development in the Department of Psychiatry. Her combined training in Psychology, Neurology and Psychiatry has provided the tools to pursue an academic career working with basic and clinical neuroscientists to advance the understanding of schizophrenia. In directing these research endeavors, she has interacted with scientists of diverse backgrounds, conducted collaborative interdisciplinary research, mentored junior faculty and trainees, and has come to know many patients and their families.  She is a member and has served in organizations including the Institute of Medicine of the National Academy of Sciences, the NIMH Council and the American Psychiatric Association task forces including the DSM-5 Psychosis work group. She is Past President of the Society of Biological Psychiatry and President Elect of the American College of Neuropsychopharmacology. NIMH has supported her research efforts and she has over 300 publications in peer-reviewed journals.

Karl and Linda Rickels Professor of Psychiatry
Vice Chair for Research Development
Director of the Neuropsychiatry Section
Member of University of Pennsylvania Psychiatry Department since 1975,
Secondary appointments in Radiology and Neurology

Education

  • Hebrew University of Jerusalem, Jerusalem, Israel 1968-70
  • Michigan State Univ, East Lansing, MI B.S. 1971 Psychology
  • Michigan State Univ, East Lansing, MI M.A. 1972 Psychology
  • Stanford University, Stanford, CA Res Assoc 1973-74 Neuropsychology
  • Michigan State Univ, East Lansing, MI Ph.D. 1974 Clin & Develop Psych
  • University of Pennsylvania, Phila, PA Post-Doc 1974-75 Clin Psychology
  • University of Pennsylvania, Phila, PA M.D. 1980


Academic Positions

1975-1987 Assistant Professor, Department of Psychiatry, Univ of PA School of Medicine, Philadelphia, PA

1980-1984 Resident, Department of Neurology, Univ of PA School of Medicine, Philadelphia, PA

1984-1986 Resident, Department of Psychiatry, Univ of PA School of Medicine, Philadelphia, PA

1984-present Director of Neuropsychiatry, Department of Psychiatry, Univ of PA School of Medcine, Philadelphia, PA

1984-1987 Assistant Professor, Departments of Psychiatry and Neurology, Univ of PA School of Medicine, Philadelphia, PA

1987-1989 Associate Professor, Departments of Psychiatry and Neurology, Univ of PA School of Medicine, Philadelphia, PA

1989-present Professor, Departments of Psychiatry, Neurology, and Radiology, Univ of PA School of Medicine, Philadelphia, PA

2002-present The Karl and Linda Rickels Professor of Psychiatry, Univ of PA School of Medicine, Philadelphia, PA

 

Hospital and Administrative Appointments

1974-1979 Faculty in Residence, Univ of PA School of Medicine, Philadelphia, PA

1982-present Department of Psychiatry, Philadelphia Veterans Administration Hospital, Philadelphia, PA

1984-present Directory of Neuropsychiatry Section, Department of Psychiatry, Univ of PA School of Medicine, Philadelphia, PA

2003-present Vice Chair for Research Development, Department of Psychiatry, Univ of PA School of Medicine, Philadelphia, PA

 

Honors:

NIMH Method to Extend Research In Time (MERIT) Award, MH42191 (1989)

Member, American College of Neuropsychopharmacology (1994)

NAMI Exemplary Psychiatrist Award (1997)

William Osler Patient Oriented Research Award (1997)

NARSAD Distinguished Investigator Award (1999)

Fellow, American College of Neuropsychopharmacology (2000)

American Psychiatric Association Kempf Fund Award (2001)

Institute of Medicine (2001)

American College of Psychiatrists Stanley Dean Award in Schizophrenia (2007)

IRG Member, Special Reviews Committee, National Institute of Mental Health (NIMH)

President,  Society of Biological Psychiatry (2007)

NARSAD - Lieber Prize for Outstanding Research in Schizophrenia (2009)

American College of Physicians – William C. Menninger Memorial Award (2011)

National Alliance on Mental Illness (Pennsylvania Montgomery County) Brain Scientific Research Award (2012)

President-Elect, American College of Neuropsychopharmacology (2013)


Selected Publications:

Gur RE. Left hemisphere dysfunction and left hemisphere overactivation in schizophrenia. Journal of Abnormal Psychology, 1978, 87, 226-238.

Gur RE, Skolnick BE, Gur RC, Caroff S, Rieger W, Obrist WD, Younkin D, Reivich M. Brain function in psychiatric disorders: I. Regional cerebral blood flow in medicated schizophrenics. Archives of General Psychiatry, 1983, 40, 1250-1254.

Gur RE, Resnick SM, Alavi A, Gur RC, Caroff S, Dann R, Silver F, Saykin AJ, Chawluk JB, Kushner M, Reivich M. Regional brain function in schizophrenia: I. A positron emission tomography study. Archives of General Psychiatry, 1987, 44, 119-125.

Gur RE, Mozley PD, Resnick SM, Shtasel DL, Kohn MI, Zimmerman RA, Herman GT, Atlas SW, Grossman RI, Erwin RJ, Gur RC. Magnetic resonance imaging in schizophrenia: I. Volumetric analysis of brain and cerebrospinal fluid. Archives of General Psychiatry, 1991, 48, 407-412.

Gur RE, Mozley PD, Shtasel DL, Cannon TD, Gallacher F, Turetsky BI, Grossman RI, Gur RC. Clinical subtypes of schizophrenia differ in brain and cerebrospinal fluid volume. American Journal of Psychiatry, 1994, 151, 343-350.

Gur RE, Mozley PD, Resnick SM, Mozley LH, Shtasel DL, Gallacher F, Arnold SE, Karp JS, Alavi A, Reivich M, Gur RC. Resting cerebral glucose metabolism and clinical features of schizophrenia. Archives of General Psychiatry, 1995, 52, 657-667.

Gur RE, Cowell P, Turetsky BI, Gallacher F, Cannon T, Bilker W, Gur RC. A followup MRI study of schizophrenia: Relationship of neuroanatomic changes with clinical and neurobehavioral measures. Archives of General Psychiatry, 1998, 55, 145-152.

Gur RE, Maany V, Mozley D, Swanson C, Bilker W, Gur RC. Subcortical MRI Volumes in Neuroleptic-Naive and Treated Patients With Schizophrenia. American J Psychiatry, 1998, 155, 1711-1717.

Gur RE, McGrath C, Chan RM, Schroeder L, Turner T, Turetsky BI, Kohler C, Alsop D, Maldjian J, Ragland JD, Gur RC. An fMRI study of facial emotion processing in schizophrenia. Am J Psychiatry. 2002;159:1992-1999. PMID: 12450947

Gur RE, Kohler CG, Turetsky BI, Siegel SJ, Kanes SJ, Bilker WB, Brennan AR, Gur RC. A sexually dimorphic ratio of orbitofrontal to amygdala volume is altered in schizophrenia. Biol Psychiatry. 2004;55:512-517. PMID: 15023579

Gur RE, Kohler CG, Ragland JD, Siegel SJ, Lesko K, Bilker WB, Gur RC.  Flat affect in schizophrenia: Relation to emotion processing and neurocognitive measures. Schizophrenia Bulletin.  2006, 32, 279-287.

Gur RE, Loughead J, Kohler CG, Elliott MA, Lesko K, Ruparel K, Wolf DH, Gur RC.
Limbic Activation Associated with Misidentification of Fearful Faces and Flat Affect in Schizophrenia. Arch Gen Psychiatry. 2007; 64:1356-1366. PMID: 18056543

Gur RC, Ragland JD, Reivich M, Greenberg JH, Alavi A, Gur RE. Regional differences in the coupling between resting cerebral blood flow and metabolism may indicate action preparedness as a default state. Cereb Cortex. 2009;19:375-382. PMID: 18534991

Wolf DH, Satterthwaite TD, Loughead J, Pinkham A, Overton E, Elliott MA, Dent GW, Smith MA, Gur RC, Gur RE. Amygdala abnormalities in first-degree relatives of individuals with schizophrenia unmasked by benzodiazepine challenge. Psychopharmacology (Berl). 2011; 218:503-512. PMID: 21603892

Wolf DH, Gerraty R, Satterthwaite TD, Loughead J, Campellone T, Elliott MA, Turetsky BI, Gur RC, Gur RE. Striatal intrinsic reinforcement signals during recognition memory: relationship to response bias and dysregulation in schizophrenia. Front Behav Neurosci. 2011;5:81. PMID:22355285

Carlson GC, Talbot K, Halene TB, Gandal MJ, Kazi HA, Schlosser L, Phung QH, Gur RE, Arnold SE, Siegel SJ. Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia. Proc Natl Acad Sci U S A. 2011; 108:E962-970. PMID: 21969553

Gur RC, Richard J, Calkins ME, Chiavacci R, Hansen JA, Bilker WB, Loughead J, Connolly JJ, Qiu H, Mentch FD, Abou-Sleiman PM, Hakonarson H, Gur RE. Age group and sex differences in performance on a computerized neurocognitive battery in children age 8-21. Neuropsychology. 2012; 26:251-265. PMID:22251308

Wolf DH, Pinkham AE, Satterthwaite TD, Ruparel K, Elliott MA, Valdez J, Smith MA, Detre JA, Gur RC, Gur RE. Oral alprazolam acutely increases nucleus accumbens perfusion. Mol Psychiatry. 2012 in press. PMID: 23070072

Satterthwaite TD, Wolf DH, Loughead J, Ruparel K, Elliott MA, Hakonarson H, Gur RC, Gur RE. Impact of in-scanner head motion on multiple measures of functional connectivity: relevance for studies of neurodevelopment in youth. Neuroimage. 2012;60:623-632. PMID: 22233733

Satterthwaite TD, Ruparel K, Loughead J, Elliott MA, Gerraty RT, Calkins ME, Hakonarson H, Gur RC, Gur RE, Wolf DH. Being right is its own reward: load and performance related ventral striatum activation to correct responses during a working memory task in youth. Neuroimage. 2012;61:723-729. PMID: 22484308

Satterthwaite TD, Elliott MA, Gerraty RT, Ruparel R, Loughead J, Calkins ME, Eickhoff SB, Hakonarson H, Gur RC, Gur RE, Wolf DH. An Improved Framework for Confound Regression and Filtering for Control of Motion Artifact in the Preprocessing of Resting-State Functional Connectivity Data. Neuroimage. 2012; 25:
240-2561. PMID: 22926292

Satterthwaite TD, Elliott MA, Ruparel K, Loughead J, Prabhakaran K, Calkins ME, Hopson R, Jackson C, Keefe J, Riley M, Mentch FD, Sleiman P, Verma R, Davatzikos C, Hakonarson H, Gur RC, Gur RE. Neuroimaging of the Philadelphia Neurodevelopmental Cohort. Neuroimage. 2013 PMID: 23921101

Tang SX, Yi JJ, Calkins ME, Whinna DA, Kohler CG, Souders MC, McDonald-McGinn DM, Zackai EH, Emanuel BS, Gur RC, Gur RE. Psychiatric disorders in 22q11.2 deletion syndrome are prevalent but undertreated. Psychol Med. 2013 Sep 9:1-11. In press. PMID: 24016317

Gur RE, Kaltman D, Melhem ER, Ruparel K, Prabhakaran K, Riley M, Yodh E, Hakonarson H, Satterthwaite T, Gur RC. Incidental findings in youths volunteering for brain MRI research. Am J Neroradiol. In press. PMID: 23811972

Complete publications

Full Curriculum Vita