BIOM 555 Control of Gene Expression
BIOM 555 (CAMB 555): GENE EXPRESSION Spring 2008
Lectures: Austrian Auditorium CRB: Tues/Thurs: 9:00-10:30 a.m.
Course Organizers: Thomas Jongens email: jongens@mail.med.upenn.edu
Paul Lieberman email: lieberman@wistar.org
Teaching Assistants:
Claude Warzecha email: claude@mail.med.upenn.edu
Alexander Brown email: sale@mail.med.upenn.edu
Jasmine Smith email: sjas@mail.med.upenn.edu
Ryan Whitmarsh email: ryanjw@mail.med.upenn.edu
BGS Administrator:
Colleen Dunn (898-2792; dunncoll@mail.med.upenn.edu; 160 BRB II/III)
Syllabus: (*please assign a discussion group paper the week before your lecture)
Lecture 1: Thursday January 17th: Regulation of Prokaryotic and Eukaryotic DNA
Replication (Paul Lieberman)
*Lecture 2: Tuesday January 22nd: Strategies of Viral Replication (Paul Lieberman)
Lecture 3: Thursday January 24th: DNA damage and repair/Cell Cycle
Checkpoints I (Eric Brown)
*Lecture 4: Tuesday January 29th: DNA damage and repair/Cell Cycle
Checkpoints II (Eric Brown)
Lecture 5: Thursday January 31st: Prokaryotic Transcriptional Regulation I (Mark Goulian)
*Lecture 6: Tuesday February 5th: Prokaryotic Transcriptional Regulation II (Mark Goulian)
Lecture 7: Thursday February 7th: Eukaryotic Transcriptional Regulation I: General Principles (Thomas Kadesch)
*Lecture 8: Tuesday February 12th: Eukaryotic Transcriptional Regulation II: Control of Transcription Factor Activity (Thomas Kadesch)
Lecture 9: Thursday February 14th: Eukaryotic Transcriptional Regulation III: CoActivator and CoRepressors (Thomas Kadesch)
*Lecture 10: Tuesday February 19th: Chromatin and Gene Regulation (Shelley Berger)
Lecture 11: Thursday February 21st: Histone modification language (Shelley Berger)
Lecture 12: Tuesday February 26th: Chromatin modification and human disease (Shelley Berger)
*Lecture 13: Thursday February 28th: long range chromatin interactions and nuclear organization (Gerd Blobel)
Lecture 14: Tuesday March 4th: Review Session
MIDTERM: Thursday March 6th (In class Examination)
Springbreak: Tuesday March 11th and Thursday March 13th
*Lecture 15: Tuesday March 18th: DNA Modification I (Marisa Bartolomei)
Lecture 16: Thursday March 20th: DNA Modification II (Marisa Bartolomei)
*Lecture 17: Tuesday March 25th: RNA Splicing (Russ Carstens)
Lecture 18: Thursday March 27th: Nuclear Import/Export (Russ Carstens)
Lecture 19: Tuesday April 1st: Nuclear Polyadenylation Assembly of RNP particles (Thomas Jongens)
*Lecture 20: Thursday April 3rd: Translational Control and RNA Localization I (Peter Klein)
Lecture 21: Tuesday April 8th: Translational Control and RNA Localization II (Peter Klein)
*Lecture 22: Thursday April 10th: RNA Editing (Thomas Jongens)
*Lecture 23: Tuesday April 15th: miRNAs/siRNAs (Zissimos Mourelatos)
(**NEWS and VIEWS article DUE by 5pm)
Lecture 24: Thursday April 17th: Nuclear Organization of Gene Expression (Susan Janicki)
*Lecture 25: Tuesday April 22nd: High-Throughput Analysis of Gene Expression (Klaus Kaestner)
Lecture 26: Thursday April 24th: DNA Delivery, Transfection and Viral Vectors (David Weiner)
Lecture 27: Tuesday April 29th: Review
Final: May 1st (in class exam)
GENERAL REFERENCES FOR REVIEW (LIBRARY/WEB)
Molecular Biology of the Cell (Alberts et al.)
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowTOC&rid=mboc4.TOC&depth=10
Molecular Cell Biology Lodish et al. (older editions are by Darnell et al.)
http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?call=bv.View..ShowTOC&rid=mcb.TOC
Genes VIII Benjamin Lewin
Lecturers:
MB: Marisa Bartolomei (898-9063 363 CRB: bartolom@mail.med.upenn.edu)
SB: Shelley Berger (898-3922 Wistar Institute: berger@wistar.org)
GB: Gerd Blobel (590-3988 316A Abramson: blobel@email.chop.edu)
EB: Eric Brown (746-2805 510 BRB II/III: brownej@mail.med.upenn.edu)
RC: Russ Carstens (573-1838 700 CRB: russcars@mail.med.upenn.edu)
TJ: Thomas Jongens (573-9332 538A CRB: jongens@mail.med.upenn.edu)
TK: Thomas Kadesch (898-1047 409 CRB: kadesch@mail.med.upenn.edu)
MG: Mark Goulian (573-6991 204F Lynch Bio Labs: goulian@sas.upenn.edu)
PL: Paul Lieberman (898-9491 Wistar: lieberman@wistar.org)
HN: Hillary Nelson (573-7473 813A Stellar Chance Labs: hnelson@mail.med.upenn.edu)
PK: Peter Klein (898-2179 364 CRB: pklein@mail.med.upenn.edu)
CS: Celeste Simon (746-5532 456 BRB II/III: celeste2@mail.med.upenn.edu)
DW: David Weiner (349-8591 505 Stellar-Chance: dbweiner@mail.upenn.edu)
SJ: Susan Janicki (215-495-6850, Wistar Institute, ?sjanicki@wistar.org)
KK: Klaus Kaestner (215-898-8759, CRB, kaestner@mail.med.upenn.edu)
ZM: Zissimos Mourelatos (215-746-0014, 613B SCL: mourelaz@uphs.upenn.edu)