Lectures: Austrian Auditorium CRB: Tues/Thurs: 9:00-10:30 a.m.
Course Organizers:
Paul Lieberman email: lieberman@wistar.org
Thomas Jongens email: jongens@mail.med.upenn.edu
Teaching Assistants:
Dustin Hanck email: hancks@mail.med.upenn.edu
Alanna Strong email: astrong@mail.med.upenn.edu
Ruchira Ranaweera email: ruchirarw@gmail.com
Adam Ewing email: ewingad@mail.med.upenn.edu
BGS Administrator:
Colleen Dunn (898-2792; dunncoll@mail.med.upenn.edu; 160 BRB II/III)
Syllabus:
Lecture 1: Thursday January 14th: Regulation of Prokaryotic and Eukaryotic DNA Replication (Paul Lieberman)
Lecture 2: Tuesday January 19th: Telomeric replication (Brad Johnson)
Lecture 3: Thursday January 21st: Prokaryotic and Eukaryotic DNA Repair/Cell Cycle Checkpoints I (Eric Brown)
Lecture 4: Tuesday January 26th: Prokaryotic and Eukaryotic DNA Repair/Cell Cycle Checkpoints II (Eric Brown)
Lecture 5: Thursday January 28th: High-Throughput Analysis of Gene Expression (Jonathan Schug)
Lecture 6: Tuesday February 2nd: Prokaryotic Transcriptional Regulation I (Mark Goulian)
Lecture 7: Thursday February 4th: Prokaryotic Transcriptional Regulation II (Mark Goulian)
Lecture 8: Tuesday February 9th: Eukaryotic Transcriptional Regulation I: General Principles (Thomas Kadesch)
Lecture 9: Thursday February 11th: Eukaryotic Transcriptional Regulation II: Control of Transcription Factor Activity (Thomas Kadesch)
Lecture 10: Tuesday February 16th: Eukaryotic Transcriptional Regulation III: CoActivator and CoRepressors (Thomas Kadesch)
Lecture 11: Thursday February 18th: Chromatin and Gene Regulation (Shelley Berger)
Lecture 12: Tuesday February 23rd: Long range chromatin interactions and nuclear organization (Gerd Blobel)
Lecture 13: Thursday February 25th: Histone modification language (Shelley Berger)
Lecture 14: Tuesday March 2nd: Chromatin modification and human disease (Shelley Berger)
MIDTERM: Thursday March 4th (In class Examination)
Springbreak: Tuesday March 9th and Thursday March 11th
Lecture 15: Tuesday March 16th: DNA Modification I (Marisa Bartolomei)
Lecture 16: Thursday March 18th: DNA Modification II (Marisa Bartolomei)
Lecture 17: Tuesday March 23rd: RNA Splicing (Russ Carstens)
Lecture 18: Thursday March 25th: Nuclear Import/Export (Russ Carstens)
Lecture 19: Tuesday March 30th: Translational Control and RNA Localization I (Peter Klein)
Lecture 20: Thursday April 1st: Translational Control and RNA Localization II (Peter Klein)
Lecture 21: Tuesday April 6th: RNA Editing (Thomas Jongens)
Lecture 22: Thursday April 8th: miRNAs/siRNAs (Zissimos Mourelatos)
NEWS AND VIEWS PAPER DUE 5:00 PM: by email: Lieberman@wistar.org
Lecture 23: Tuesday April 13th: Pi RNAs (Zissimos Mourelatos)
Lecture 24: Thursday April 15th: Non-Coding Cryptic RNAs (Ramin Shiekhattar)
Lecture 25: Tuesday April 20th: RNA directed heterochromatin (Paul Lieberman)
Lecture 26: Thursday April 22nd: Regulation of Protein Function by Post-translational modification (Thomas Jongens)
Lecture 27: Tuesday April 27th: Review
Final: April 29th (Austrian Auditorium-`~ 9-10:30)
GENERAL REFERENCES FOR REVIEW (LIBRARY/WEB)
Molecular Biology of the Cell (Alberts et al.)
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowTOC&rid=mboc4.TOC&depth=10
Molecular Cell Biology Lodish et al. (older editions are by Darnell et al.)
http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?call=bv.View..ShowTOC&rid=mcb.TOC
Genes VIII Benjamin Lewin
Lecturers:
MB: Marisa Bartolomei (898-9063 363 CRB: bartolom@mail.med.upenn.edu)
SB: Shelley Berger (CRB: bergers@mail.med.upenn.edu)
GB: Gerd Blobel (590-3988 316A Abramson: blobel@email.chop.edu)
EB: Eric Brown (746-2805 510 BRB II/III: brownej@mail.med.upenn.edu)
RC: Russ Carstens (215-573-1838 411 Hill Pavilion: russcars@mail.med.upenn.edu)
BJ: Brad Johnson (573-5037 405A SCL: johnsonb@mail.med.upenn.edu)
TJ: Thomas Jongens (573-9332 538A CRB: jongens@mail.med.upenn.edu)
TK: Thomas Kadesch (898-1047 409 CRB: kadesch@mail.med.upenn.edu)
MG: Mark Goulian (573-6991 204F Lynch Bio Labs: goulian@sas.upenn.edu)
PL: Paul Lieberman (898-9491 Wistar: lieberman@wistar.org)
PK: Peter Klein (898-2179 364 CRB: pklein@mail.med.upenn.edu)
ZM: Zissimos Mourelatos (215-746-0014, 613B SCL: mourelaz@uphs.upenn.edu)
JS: Jonathan Schug (898-0773, 752A CRB: jschug@mail.med.upenn.edu)
RS: Ramin Shiekhattar (215-898-3896 Wistar