Co-Director: Englander (engl@mail.med.upenn.edu)

Co-Director: Axelsen (axe@pharm.med.upenn.edu)

TA: John Skinner (skinnerj@mail.med.upenn.edu)

Lecture

Topic

Lecturer: date

1

Introduction to equilibrium and kinetic principles, and methods

Englander 9/7

2

Methods – literature examples

Englander   11

3

Views of how it works: The ‘old’ and ‘new’ view

Englander   14

4

Structure of folding intermediates – kinetic studies

Englander   18

5

Structure of folding intermediates – equilibrium studies

Englander   21

6

Structure of folding intermediates – theoretical simulations

Englander   25

7

The kinetic determinants –  contact order/folding rate

Englander   28

8 

Kinetic transition states – phi analysis

Englander10/2

9

Kinetic transition states – psi analysis

Englander     5

10

Helping out – chaperones

Englander     9

11

Protein folding in and on membranes - theoretical studies

Axelsen      12

12

Protein folding in and on membranes - experimental studies

Axelsen      16

13

Amyloid – to be decided

Axelsen      19