BMB/CHEM 700 Frontiers in Bioorganic and Medicinal Chemistry
Fall 2007 MWF 11, 514 Chemistry
The course explores how recent developments in our abilities to make and analyze biologically important macromolecules provide new approaches to drug development and discovery.
Prerequisites: Open to all graduate students in the Chemistry, Biochemistry/Molecular Biophysics and Pharmacology departments and/or graduate groups. Other students should consult with Dr. Cooperman before enrolling. In general, a strong background in undergraduate chemistry is required, and at least one semester of biological chemistry is very desirable.
2 hourly exams Oct 1, Oct. 29 – 100 pts each 1 final 150 pts
9/5 Peptide structure, amino acids and conformational properties. DeGrado
9/7 Peptide structure, turns and bioactive peptides. DeGrado
9/10 Peptide structure, statistical mechanics of helix formation. DeGrado
9/12 Forces stabilizing protein structure and molecular recognition DeGrado
9/14 Beta-proteins DeGrado
9/17 Helical proteins DeGrado
9/19 Membrane proteins DeGrado
9/21 Foldamers DeGrado
9/24 Synthesis of polypeptides DeGrado
9/26 Sequencing of polypeptides/Biosynthesis of polypeptides Cooperman
9/28 Biosynthesis of polypeptides Cooperman
10/01 Exam 1
10/03 DNA structure Cooperman
10/05 Nucleotide modification and consequences Cooperman
10/08 Biosynthesis and chemical synthesis of nucleic acids Cooperman
10/10 protein:DNA interaction van Duyne
10/12 van Duyne - protein:DNA interaction van Duyne
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10/17 Mass spectrometry and small molecules Blair
10/19 Mass spectrometry and Small molecules Blair
10/22 Mass spectrometry and Proteomics Blair
10/24 Mass spectrometry and DNA Adducts Blair
10/26 Oxidative DNA Damage Blair
10/29 Exam 2
10/31 Mass spectrometry and Lipids - Blair
11/2 Introduction to Drug Metabolism Blair
11/5 Characterization of Drug Metabolism Blair
11/7 RNA structure and sequencing Cooperman
11/9 RNA motifs/ribozymes Cooperman
11/12 Aptamers Cooperman
11/14 Modifications to proteins by endogenous reactive intermediates Blair
11/16 Modifications to proteins by exogenous reactive intermediates Blair
11/19 Introduction to Metabolomics Blair
11/21 Mechanism of Translation Cooperman
11/26 Expansion of the Genetic Code Cooperman
11/28 mRNA and ribosome display Cooperman
11/30 Biomimetics Vinograd
12/3 Biomimetics Vinograd
12/5 Oligosaccharide structure and function Cooperman
12/7 Oligosaccharide synthesis Cooperman