CAMB 511 Principles of Development
Date |
Topic |
Lecturer |
1/15 |
Organizational Meeting |
|
1/17 |
Fertilization, cleavage, midblastula transition, cell lineage and fate maps |
Mary Mullins |
1/18 |
Body plan formation: Gastrulation, germ layer formation and morphogenesis |
Dan Kessler |
1/22 |
Establishment of cellular polarity: oogenesis and cytoplasmic determinants |
Mary Mullins |
1/24 |
Establishment of polarity: Cortical rotation and inductive signals |
Peter Klein |
1/25 |
Discussion |
MM |
1/29 |
Induction of the primary germ layers |
Dan Kessler |
1/31 |
Development and genetics of C. elegans |
Meera Sundaram |
2/1 |
Discussion [Room 601 BRBII/III] |
DK |
2/5 |
Classical embryology of insects: Determinants and morphogens before genetics and molecular biology |
Mary Mullins |
2/7 |
Creating periodic patterns |
Mary Mullins |
2/8 |
Discussion |
MM |
2/12 |
Establishment of the AP and DV axes in Drosophila |
Mary Mullins |
2/14 |
Morphogens and pattern |
Mary Mullins |
2/15 |
Discussion [2:00-3:00PM] |
MM |
2/19 |
Formation and function of the vertebrate organizer |
Dan Kessler |
2/21 |
Vertebrate neural induction |
Dan Kessler |
2/22 |
Discussion |
DK |
2/26 |
Somite patterning and muscle differentiation [Room 601 BRBII/III] |
Dan Kessler |
2/28 |
Establishing neuronal identity along the dorsoventral neuraxis |
Doug Epstein |
2/29 |
Discussion [Room 601 BRBII/III] MIDTERM EXAM |
DK |
3/4 |
The generation and function of neural crest |
Jean-Pierre Saint-Jeannet |
3/6 |
AP neural patterning in vertebrates |
Jeff Golden |
3/7 |
Discussion MIDTERM EXAM Due |
MM |
3/8-3/16 |
Spring Break |
|
3/18 |
Early development and genetics of the zebrafish |
Mary Mullins |
3/20 |
Early development and genetics of the mouse |
Ben Stanger |
3/21 |
Discussion |
DK |
3/25 |
Organogenesis: Eye, Heart, Pancreas, and Liver |
Ben Stanger |
3/27 |
Branching morphogenesis: Lung and Kidney |
Amin Ghabriel |
3/28 |
Discussion [2:00-3:00PM] |
BS |
4/1 |
Cell differentiation programs: Blood and Vasculature |
Mark Kahn |
4/3 |
Left-right asymmetry and patterning of the body axes |
Dan Kessler |
4/4 |
Discussion |
DK |
4/8 |
Phase change in plant development |
Scott Poethig |
4/10 |
Regulating the switch to reproductive development in plants |
Doris Wagner |
4/11 |
Discussion [2:00-3:00PM] |
MM |
4/15 |
Stem Cells I: Germ Line and Embryonic Stem Cells |
Steve DiNardo |
4/17 |
Stem Cells II: Adult Stem Cells |
George Cotsarelis |
4/18 |
Discussion |
SD |
4/22 |
Evo-Devo I |
Steve DiNardo |
4/24 |
Evo-Devo II |
Steve DiNardo |
4/25 |
Discussion [Room 1101 BRBII/III] FINAL EXAM |
SD |
5/2 |
FINAL EXAM Due |
PRINCIPLES OF DEVELOPMENT CAMB 511, Spring 2008
Course directors:
Dan Kessler Mary Mullins
Dept. of Cell and Developmental Biology Dept. of Cell and Developmental Biology
1110 BRBII/III 1211 BRBII/III
898-1478 898-2644
kesslerd@mail.med.upenn.edu mullins@mail.med.upenn.edu
Course faculty:
George Cotsarelis, cotsarel@mail.med.upenn.edu
Steve DiNardo, sdinardo@mail.med.upenn.edu
Doug Epstein, epsteind@mail.med.upenn.edu
Amin Ghabrial, ????@mail.med.upenn.edu
Jeff Golden, goldenj@mail.med.upenn.edu
Peter Klein, pklein@mail.med.upenn.edu
Jean-Pierre Saint-Jeannet, saintj@vet.upenn.edu
Scott Poethig, spoethig@sas.upenn.edu
Mark Kahn, markkahn@mail.med.upenn.edu
Ben Stanger, bstanger@mail.med.upenn.edu
Meera Sundaram, sundaram@mail.med.upenn.edu
Doris Wagner, wagnerdo@sas.upenn.edu
Class Schedule:
Room 1201 BRBII/III [Please note changes to room or time for a few class meetings]
Lectures-Tuesday and Thursday 1:30-3:00
Discussions-Friday 1:30-2:30
Recommended Text:
Developmental Biology (8th edition) by Scott F. Gilbert
Discussions:
Each week 1-2 research articles will be assigned for mandatory reading. One student will present background to the articles to the rest of the class. All students will be involved in presenting the articles at each meeting.
Exams:
The midterm and final exams will be take-home written exams in essay format.
Grading:
Grades will be based on presentations, participation in the discussion sessions, and attendance (33%), the midterm exam (33%), and the final exam (33%).
Course Website:
A course website (courseweb.library.upenn.edu/) is available at the Penn Blackboard site. The website includes the course schedule, syllabus, faculty contact information and discussion papers for download. In addition, course lectures will be posted as Powerpoint files following each lecture.