CAMB 532 Human Physiology
This course will present a survey of the physiology of most of the major organ systems. It will integrate knowledge of cellular and molecular mechanisms into an understanding of function at the tissue, organ and organism levels. It will begin with a brief review of membrane physiology, followed by electrophysiology and signaling in nerve. Then, after a brief outline of neural control systems and their role in homeostasis, it will present motility and muscle, the cardiovascular system, respiration, the renal system, selected topics from the endocrine system and the gastrointestinal system. As well as providing a basis of integrative physiology for students in fields such as bioengineering and pharmacology, it should be of interest to students of cellular and molecular biology and genetic engineering who will need to appreciate the roles of specific systems and molecules at higher levels of organization.
Required text: Medical Physiology, updated edition, Walter F.
Boron and Emile L. Boulpaep, Elsevier-Saunders,
2005.
Format: Three 1.5 hour lectures per week.
Evaluation: Three non-cumulative multiple-choice exams,
each covering about one third of the course.
Prerequisites: Although not a formal prerequisite, a good foundation in cell biology at the level of BIOM 600 (or an equivalent upper level undergraduate course) is strongly recommended. A general understanding of the chemistry and biochemistry of macromolecules, and of basic molecular biology will also be assumed.
Fall 2007 Mon, Weds, Fri, 9:00-10:30am
Directors: Dr Martin Pring and Kevin Foskett
Sept 7 |
BRB 1412 |
Dr. Pring |
Orientation |
Membrane Electrophysiology & Nerve |
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Sept 10 |
BRB 253 |
Dr. Hoshi |
Action Potentials |
Sept 12 |
BRB 253 |
Dr. Hoshi |
Voltage-gated Ion Channels |
Sept 14 |
BRB 253 |
Dr. Hoshi |
Synaptic Transmission and Ligand-gated Ion Channels |
Sept 17 |
BRB 253 |
Dr. Thomas |
Autonomic Nervous System |
Muscle |
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Sept 19 |
BRB 253 |
Dr. Baylor |
Skeletal Muscle Signaling |
Sept 21 |
BRB 1412 |
Dr. Baylor |
Cardiac Signaling |
Sept 24 |
BRB 253 |
Dr. Ostap |
Contractile Proteins |
Sept 26 |
BRB 253 |
Dr. Ostap |
Muscle Contraction |
Sept 28 |
No Class |
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Oct 1 |
TBA |
Mid-term 1 |
|
Cardiovascular System |
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Oct 3 |
BRB 253 |
Dr. Sweeney |
Smooth Muscle |
Oct 5 |
BRB 1412 |
Dr. Goldman |
Organization; Arteries & Veins; the Microcirculation |
Oct 8 |
BRB 253 |
Dr. Goldman |
Electrophysiology and the EKG; the Heart as a Pump |
Oct 10 |
BRB 1412 |
Dr. Goldman |
Regulation of Arterial Pressure and Cardiac Output |
Oct 12 |
BRB 253 |
Dr. Goldman |
Special Circulations; Integrated Control |
Respiration |
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Oct 15 |
BRB 253 |
Dr Grippi |
Functional Anatomy and Respiratory Mechanics |
Oct 17 |
BRB 253 |
Dr Grippi |
Ventilation, Perfusion, and Gas Exchange |
Oct 19 |
BRB 253 |
Dr Grippi |
Oxygen and Carbon Dioxide Transport |
Oct 22 |
BRB 253 |
Dr Grippi |
Control of Respiration |
Renal System |
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Oct 24 |
BRB 253 |
Dr. Civan |
Introduction & Glomerular Filtration |
Oct 26 |
BRB 253 |
Dr. Civan |
Clearance, Blood Flow & K+ Regulation |
Oct 29 |
BRB 253 |
Dr. Civan |
Regulation of Na+ Excretion |
Oct 31 |
BRB 253 |
Dr. Civan |
Regulation of Acid Excretion |
Nov 2 |
BRB 253 |
Dr. Civan |
Regulation of Water Excretion |
Nov 5 |
No Class |
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Nov 7 |
BRB 253 |
Mid-term 2 |
|
Nov 9 |
BRB 253 |
Dr Birnbaum |
Organization of Endocrine Control |
Nov 12 |
BRB 253 |
Dr Birnbaum |
Endocrine Control of Growth |
Nov 14 |
BRB 253 |
Dr Birnbaum |
Thyroid and Adrenal Glands |
Nov 16 |
BRB 253 |
Dr Birnbaum |
Endocrine Control of Metabolism |
Integration |
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Nov 19 |
BRB 253 |
Dr. Khurana |
Physiological Responses to Exercise |
Nov 21 |
No Class |
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Nov 23 |
Thanksgiving |
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Nov 26 |
BRB 253 |
Dr. Khurana |
Response to Altitude and Temperature |
Gastrointestinal System |
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Nov 28 |
BRB 253 |
Dr. Foskett |
Organization of the System |
Nov 30 |
BRB 253 |
Dr. Foskett |
Mouth to Stomach |
Dec 3 |
BRB 253 |
Dr. Foskett |
Gastric Function |
Dec 5 |
BRB 253 |
Dr. Foskett |
Pancreas and Hepatobiliary System |
Dec 7 |
BRB 253 |
Dr. Foskett |
Intestinal Functions |
Dec 10 |
No Class |
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Dec 12 |
No Class |
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Dec 14 |
BRB 253 |
Final |
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Human Physiology CAMB 532 Faculty
"J Kevin Foskett" <foskett@mail.med.upenn.edu>, "Martin Pring" <pringm@mail.med.upenn.edu>, "Toshinori Hoshi" <hoshi@mail.med.upenn.edu>, "Steven Thomas" <thomas@pharm.med.upenn.edu>, "Stephen Murray Baylor" <baylor@mail.med.upenn.edu>, "Michael Ostap" <ostap@mail.med.upenn.edu>, “H Lee Sweeney” <lsweeney@mail.med.upenn.edu>, "Yale E Goldman" <goldmany@mail.med.upenn.edu>, "Grippi, Michael" <Michael.Grippi@va.gov>, "Mortimer M Civan" <civan@mail.med.upenn.edu>, "Morris J Birnbaum" <birnbaum@mail.med.upenn.edu>, "Tejvir S Khurana" <tsk@mail.med.upenn.edu >
J Kevin Foskett |
898-1354 |
foskett@mail.med.upenn.edu |
Martin Pring |
898-6870 |
pringm@mail.med.upenn.edu |
Toshinori Hoshi |
573-7305 |
hoshi@mail.med.upenn.edu |
Steven Thomas |
573-4950 |
thomas@pharm.med.upenn.edu |
Stephen Baylor |
898-5559 |
baylor@mail.med.upenn.edu |
Michael Ostap |
573-9758 |
ostap@mail.med.upenn.edu |
H Lee Sweeney |
898-8727 |
lsweeney@mail.med.upenn.edu |
Yale E Goldman |
898-4017 |
goldmany@mail.med.upenn.edu |
Michael Grippi |
215-823-4576 |
Michael.Grippi@va.gov |
Mortimer M Civan |
898-8773 |
civan@mail.med.upenn.edu |
Morris J Birnbaum |
898-5001 |
birnbaum@mail.med.upenn.edu |
Tejvir S Khurana |
573-2640 |
tsk@mail.med.upenn.edu |