CAMB 540/BIOL 541 Genetic Analysis

T-Th, 10:30-12, Goddard 101

Dr. Scott Poethig
103E Lynch, 215-898-8915, spoethig@sas.upenn.edu

Description: This course is intended for advanced undergraduates and graduate students who have had an introductory course in genetics. The course will consist of lectures and discussions of problems and papers that illustrate the topics covered in lecture. Grades will be based on a midterm, a final exam, and a term paper. Readings will be taken from the literature, and will be available via Blackboard.

Date/ Topic/ Lecturer
Jan. 17/ Principles of genetic analysis/ Poethig
22/ Genes and genomes/ Poethig
24/ Mutagenesis; types of mutations/ Poethig
29/ Chromosomal rearrangements/ Poethig
31/ Transposons/ Poethig
Feb. 5/ Mapping: Markers, recombination mapping/ Poethig
7/ Mapping: positional cloning/ Poethig
12/ Reverse genetics: tilling, transposons/ Poethig
14/ RNAi, epigenetics/ Poethig
19/ Epistasis analysis/ Poethig
21/ Types of genetic interactions/ Poethig
26/ Genetic mosaics/ Poethig
28/ Transactivation: enhancer traps, GAL4, etc/. Poethig
March 4/ Natural variation/ Poethig
6 Midterm
11 Break
13 Break
18/ Drosophila: Life history, genetics, genomics/ Lessing
20/ -saturation screen for embryonic patterning mutants/ Lessing
25/ -genetics of a complex locus: Bithorax/ Poethig
27/ -TBD Poethig
April 1/ C. elegans: Life history, genetics, genomics/ Poethig
3/ -the heterochronic pathway/ Poethig
8/ -the discovery of miRNAs/ Poethig
10/ Mouse: Life history, genetics, genomics/ Bucan
15/ -behavioral genetics/ Bucan
17/ -cancer genetics; the MOM1 story/ Poethig
22/ Arabidopsis: Life history, genetics, genomics/ Poethig
24/ The initiation and maintenance of the shoot meristem/ Poethig
29/ Natural variation in Arabidopsis/ Poethig
May 8/ Final Exam, 9-11AM