CAMB/PHRM 542 Topics in Molecular Medicine

SYLLABUS
Topics in Molecular Medicine
Fall Term 2005, Wednesdays, 3:30 p.m, 401 BRB II/III

Articles marked by ** are available on the TiMM website as PDF files (look under the faculty name to find them). The class schedule and faculty contact information are also available on this website. The address is http://www.afcri.upenn.edu:416/index.htm. Please call Samantha Cadieux 898-3482 if you have any questions.

Class #1 – Craig Thompson – September 7
1. ** Kwiatkowski, DJ. Tuberous sclerosis: from tuber to mTOR. 2003. Annals of Human Genetics. 67:87-96
2. ** Inoki K, Li Y, Zhu T, Wu J, and Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. 2002. Nature Cell Biology. 4:648-657.

Class #2 – Josh Dunaief – September 14
1. ** Bennett J, Maguire AM, Cideciyan AV, Schnell M, Glover E, Anand V, Aleman TS, Chitmule N, Gupta AR, Huang Y, Gao GP, Nyberg WC, Tazelaar J, Hughes H, Wilson JM, and Jacobson SG. Stable transgene expression in rod photoreceptors after recombinant adeno-associated virus-mediated gene transfer to monkey retina. 1999. Proc. Nat’l Acad. Sci. 96:9920-25.
2. ** Acland GM, Aguirre GD, Ray J, Zhang Q, Aleman TS, Cideciyan AV, Pearce-Kelling, SE, Anand V, Zeng Y, Maguire AM, Jacobson SG, Hauswirth WW, and Bennett J. Gene therapy restores vision in a canine model of childhood blindness. 2001. Nature Genetics. 28:92-95.

Class #3 – Steve Scherer – September 21
1. ** Loddenkemper T, Grote K, Evers S, Oelerich M, and Stögbauer F. Neurological manifestations of oculodentodigital dysplasia syndrome. 2002. J. Neurol. 249:584-595.
2. ** Roscoe W, Veitch G, Gong X, Pellegrino E, Bai D, McLachlan E, Shao Q, Kidder G, and Laird D. Oculodentodigital dysplasia-causing connexin43 mutants are non-functional and exhibit dominant effects on wild-type connexin43. 2005. Journal of Biological Chemistry. 280(12): 11458-11466.

Class #4 – Bob Doms – September 28
1. ** Greene W. The brightening future of HIV therapeutics. 2004. Nature Immunology. 5(9):867-871.
2. ** Harris R, Bishop K, Sheehy A, Craig H, Peterson-Mahrt S, Watt I, Neuberger M, and Malim M. DNA deamination mediates innate immunity to retroviral infection. 2003. Cell. 113:803-809.

Class #5 – Warren Pear – October 5
1. ** Pui C, Relling M, Pharm D, and Downing J. Mechanisms of Disease; Acute Lymphoblastic Leukemia. 2004. New England Journal of Medicine. 350:1535-1548.
2. ** Weng A, Ferrando A, Lee W, Morris J, Silverman L, Sanchez-Irizarry C, Blacklow S, Look T, and Aster J. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. 2004. Science. 306:269-271
3. ** Weng Aster Supplementary Data

Class #6 – Jim Hoxie – October 12
1. ** Garber DA, Silvestri G, and Feinberg MB. Prospects for an AIDS vaccine: three big questions, no easy answers. 2004. Review. Lancet Infectious Disease. 4(7):397-413.
2. ** Richman DD, Wrin T, Little SJ, and Petropoulos CJ. Rapid evolution of the neutralizing antibody response to HIV type 1 infection. 2003. Proc Natl Acad Sci USA. 100(7):4144-4149.
Class #7 – Kathy High – October 19
1. ** Dworetzky M, and Cohen S. A historical review of bone marrow transplantation for immunodeficienceies. 2004. Journal of Allergy and Clinical Immunology. 793-800
2. ** Buckley RH. The multiple causes of human SCID. 2004. The Journal of Clinical Investigation. 114:10 1409-1411.
3. ** Urnov F, Miller J, Lee Y, Beausejour C, Rock J, Augustus S, Jamieson A, Porteus M, Gregory P, and Holmes M. Highly efficient endogenous human gene correction using designed zinc-finger nucleases. 2005. Nature Publishing Group. 1-6.

Class #8 – Morrie Birnbaum – October 26
1. ** Farooqi IS, and O’Rahilly S. Monogenic human obesity syndromes. 2004. The Endocrine Society. 409-424.
2. ** Bates SH, Stearns WH, Dundon TA, Schubert M, Tso AWK, Wang Y, Banks AS, Lavery HJ, Haq AK, Maratos-Flier E, Neel BG, Schwartz MW, and Myers MG. STAT3 signaling is required for leptin regulation of energy balance but not reproduction. 2003. Nature Publishing Group, Nature. 421:856-859.

Class #9 – Mitch Lazar – November 2
1. ** Eckel RH, Grundy SM, and Zimmet PZ. The metabolic syndrome. 2005. The Lancet. 365:1415-1428.
2. ** Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H, and Evans RM. Peroxisome-proliferator-activated receptor δ activated fat metabolism to prevent obesity. 2003. Cell. 113:159-170.

Class #10 – Gary Wu – November 9
1. ** Podolsky D. Inflammatory bowel disease. 2002. Review Article, N. England. J. Med. 347:(6) 417-429.
2. ** Kobayashi K, Chamaillard M, Ogura V, Henegariu O, Inohara N, Nuñez G, and Flavell R. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. 2005. Science. 307:731-734.
3. ** Maeda S, Hsu L, Bankstorm L, Limura M, Kagnoff M, Eckmann L, and Karin M. Nod2 mutation in Crohn’s disease potentiates NF-?B activity and IL-1ß processing. 2005. Science. 307: 734-738.

Class #11 – Gerd Blobel – November 30
1. ** Gilliland DG, Jordan TJ, and Felix CA. The molecular basis of leukemia. 2004. Clinical Review. American Society of Hematology. 80-97.
2. ** Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, and Zhang Y. hDOT1L links histone methylation to leukemogenesis. 2005. Cell. 121:167-178.

Class #12 – Brad Johnson – December 7
1. ** Chen L, and Oshima J. Werner Syndrome. 2002. Clinical Review. Journal of Biomedicine and Biotechnology. 2:2 46-54.
2. ** Crabbe L, Verdun RE, Haggblom C, and Karlseder J. Defective telomere lagging strand synthesis in cells lacking wrn helicase activity. 2004. Science. 306:1951-1953.

Class #13 – George Cotsarelis – December 14
1. ** Olsen EA, Messenger AG, Shapiro J, Bergfeld WF, Hordinsky MK, Roberts JL, Stough D, Washenik K, and Whiting DA. Evaluation and treatment of male and female pattern hair loss. 2005. J Am Acad Dermatology. 52(2):301-311.
2. ** Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M, and Fuchs E. Defining the epithelial stem cell niche in skin. 2004. Science. 303:359-363
Class #14 – Becky Wells – January 4
1. Mechanisms of Chronic Renal Failure. The McGraw-Hill Companies. 2004-2005. Part 11. Disorders of the Kidney and Urinary Tract, Chapter 261. Chronic Renal Failure. 1-4.
2. ** Iwano M, Plieth D, Danoff TM, Xue C, Okada H, and Neilson EG. Evidence that fibroblasts derive from epithelium during tissue fibrosis. 2002. The Journal of Clinical Investigation. 110(3):341-350.

Class #15 – Mark Kahn – January 11
1. ** Rowland, LP and Shneider NA. Amyotrophic Lateral Sclerosis. 2001. Clinical Review. New England Journal of Medicine. 344(22):1688-1700.
2. ** Oosthuyse B, Moons L, Storkebaum E, Beck H, Nuyens D, Brusselmans K, Van Dorpe J, Hellings P, Gorselink M, Heymans S, Theilmeier G, Dewerchin M, Laudenbach V, Vermylen P, Raat H, Acker T, Vlemickz F, Hicklin DJ, Ince C, Gressens P, Lupu F, Plate KH, Robberecht W, Herbert JM, Collen D, and Carmeliet P. Deleteion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. 2001. Nature Genetics. 28:131-138.