CAMB 605 1st Year Seminar
CAMB 605 - First Year Seminar (Fall 2007): Course Syllabus
Weeks 1-6: Students lead round-table discussion of assigned papers.
Weeks 7-12: Students lead round-table discussion of papers selected from assigned topics.
Presentation 1: Faculty chosen papers (Weeks 1-6)
September 18: Paper 1 (Doug Epstein), Paper 2 (Doug Epstein)
- Caspary, T., et al. (2007). The graded response to Sonic Hedgehog depends on cilia architecture. Dev Cell 12: 767-78.
- Rohatgi, R., et al. (2007). Patched1 regulates hedgehog signaling at the primary cilium. Science 317: 372-6.
September 25: Paper 3 (John Seykora), Papers 4a and 4b (Ben Black)
- Zenz, R., et al. (2005). Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins. Nature 437: 369-375.
4a. Tomita, J., et al. (2005). No Transcription-Translation Feedback in Circadian
Rhythm of KaiC Phosphorylation. Science 307: 251-254.
4b. Nakajima, M., et al. (2005). Reconstitution of Circadian Oscillation of
Cyanobacterial KaiC Phosphorylation in Vitro. Science 308: 414-415.
October 2: Paper 5 (Doron Greenbaum), Paper 6 (Doron Greenbaum)
- Baruch, D., I., et al. (1995). Cloning the P. falciparum Gene Encoding PfEMP1, a Malarial Variant Antigen and Adherence Receptor on the Surface of Parasitized Human Erythrocytes. Cell 82:77-87.
- Crabb, B.S., et al. (1997). Targeted Gene Disruption Shows that Knobs Enable Malaria-Infected Red Cells to Cytoadhere under Physiological Shear Stress. Cell 89: 287-296.
October 9: Paper 7 (Vivian Cheung), Paper 8 (Vivian Cheung)
9. He, L., et al. (2007). A microRNA component of the p53 tumour suppressor network. Nature 447: 1130-1134.
10. Aitman, T.J., et al. (2006). Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature 439: 851-855.
October 16: Paper 9 (Dwight Stambolian), Paper 10 (Mike Betts)
11. Klein, R.J., et al. (2005). Complement Factor H Polymorphism in Age-Related Macular Degeneration. Science 308: 385-389.
12. Stern-Ginossar, N., et al. (2007). Host Immune System Gene Targeting by a Viral miRNA. Science 317: 376-380.
October 23: Paper 11 (Wei Tong), Paper 12 (Catherine Lee May)
7. Yilmaz, O., et al. (2006). Pten Dependence Distinguishes Haematopoietic Stem Cells from Leukaemia-Initiating Cells. Nature 441: 475-482.
8. Collombat, P., et al. (2007). Embryonic Endocrine Pancreas and Mature b cells Acquire a and PP Cell Phenotypes upon Arx Misexpression. J Clin. Inv. 117: 961-970
Presentation 2: Student chosen papers from list of topics (Weeks 7-12)
October 30: Topic 1 (John Seykora), Topic 2 (Mike Betts)
- Murine models of psoriasis
- Pathogen modulation of immune responses
November 6: Topic 3 (Catherine Lee May), Topic 4 (Catherine Lee May)
- Endodermal organ formation
- Beta cell growth and survival in diabetes mellitus
November 13: Topic 5 (Ben Black), Topic 6 (Ben Black)
November 20: Topic 7 (Vivian Cheung), Topic 8 (Doron Greenbaum)
- Genetic basis of human disease
- The function of proteases in metastasis
November 27: Topic 9 (Wei Tong), Topic 10 (Wei Tong)
- Hematopoietic stem cells and leukemia
- The hematopoietic stem cell niche
December 4: Topic 11 (Doug Epstein), Topic 12 (Dwight Stambolian)
- Cis regulatory changes in animal evolution
- Iron regulatory proteins and cataract