GCB 752 Seminar in Genomics
Harold Riethman
Spring 2008
Thursdays 3 PM to 6 PM
BRB 252
Prerequisite: GCB 531 Intro to Genomics or equivalent or permission of instructor
Class Size limited to 16.
The class will meet once a week for a 3 hr period. Recent papers from the primary genomics literature will form the core material for the course. Each 3-hr session will feature a major topic in Genomics, with student presentations (usually two per session) centered on papers selected within the topic area. While the “presenting” student will give a 10- 15 min introduction to the paper and will show powerpoint slides of the data in the paper, all students in the class are expected to have read and to be prepared to discuss the papers presented. For example, following the introduction, non-presenting students will be called upon to explain a particular table or figure, or to discuss a point raised in the paper. Grades will be based upon the student presentations and upon class participation.
Some topics will be decided upon jointly by the students and the course organizers during the Introductory/Organizational meeting on January 17. Topics that will be covered this semester include:
Mandatory Topics selected by course organizers
Gene Expression Profiling and Cancer
High-throughput Sequencing (Solexa and 454) Applications
Genome-wide Location Analysis, ChIP
HapMap and Association Studies
DNA re-sequencing and mutational profiling in Cancer
Comparative Genomics and Genome Annotation
Analysis of Copy Number Polymorphisms (CNPs) and Structural Variation
Genome-wide functional analysis using RNA interference
Protein Interaction Networks
Elective Topics selected by students in class discussion
Epigenomics
Ecological Genomics/ Metagenomics
Comparative Genomics and Human-Primate comparisons
Synthetic Biology
Proteomics and biomarkers
SNPs and the regulation of gene expression.
Variation in Gene Expression
Genome-wide functional screens
Other…
The course organizers may suggest potential papers for each topic. Students can either select papers for presentation from among the course organizers’ selections, or they may choose their own papers subject to approval by the course organizers.