UPENN Biomedical Graduate Studies|insc 596 sp08

PHRM 510/INSC 596 Neuropharm/Neurochem

Neuropharmacology/Neurochemistry (PHRM 510, INSC 596) Spring 2008

TIME: MWF 1-2 PM

LOCATION: John Morgan Bldg, M100 (Mezzanine level)

TEXT: Basic Neurochemistry, 7th Edition, c. 2005. Ed: G. J. Siegel et al.; Lippincott

Available at Penn Book Store, 36th & Walnut. $99

For another perspective, the library has copies of:

Molecular Neuropharmacology, c. 2001. Ed: E. J. Nestler et al.; McGraw-Hill

WEB: Blackboard – for lecture notes, non-text readings & old exams

REQUIREMENTS: 4 written, short answer, in-class examinations – each 25% of grade

COURSE DIRECTORS:

Steve Thomas 573-4950 thomas@pharm.med.upenn.edu

Randy Pittman 898-9736 pittman@pharm.med.upenn.edu

Ben Giasson 573-6012 giassonb@mail.med.upenn.edu

Teresa Reyes 573-2991 reyestm@mail.med.upenn.edu

TA: Jackie Morris 573-4951 jacquefm@mail.med.upenn.edu

GOALS:

To provide a general overview of the signaling properties of the nervous system.
To provide in-depth information on neurotransmitter and associated signaling systems. Emphasis will be placed on the wealth of new molecular information that is being gathered to examine how cells of the nervous system function and communicate.

SCHEDULE

Day	Date	Subject	Instructor

		A. Intracellular Signaling	Steven Thomas
*Mon*	*1/14*	1. Introduction to Neuropharmacology *12-1 PM*	Steven Thomas
*Mon*	*1/14*	2. Neurotransmitter release (Ch 9 & 10)	Tom Parsons
*Wed*	*1/16*	3. Cytoskeleton and axonal transport (Ch 1, 8, 28) *12-1 PM*	Randy Pittman
*Wed*	*1/16*	4. Neurotransmitter transporters (Ch 5 & Torres et al.)	Mike Robinson
*Fri*	*1/18*	5. G proteins and receptors (Ch 19) *12-1 PM*	Steve Thomas
*Fri*	*1/18*	6. Calcium (Ch 22)	Frank Horrigan
Mon	1/21	*MLK Day, No Class*
Wed	1/23	7. Phospholipids (Ch 20)	Mark Lemmon
Fri	1/25	8. Cyclic nucleotides (Ch 21)	Ted Abel
Mon	1/28	9. Protein kinases (Ch 23 & 24)	Jeff Field
Wed	1/30	10. Transcription (Ch 26)	Jim Eberwine
Fri	2/1	Exam 1: 12 – 2 PM
		B. Neurotransmitter Systems	Ben Giasson
Mon	2/4	11. Purines (Ch 17)	Perry Molinoff
*Wed*	*2/6*	12. Excitatory amino acids I (Ch 10 & 15) *12-1 PM*	Mike Robinson
*Wed*	*2/6*	13. Excitatory amino acids II (Ch 15)	Dave Lynch
Fri	2/8	14. Inhibitory amino acids I (Ch 16)	Tom Ferraro
Mon	2/11	15. Inhibitory amino acids II (Ch 16)	Tom Ferraro
Wed	2/13	*No class (due to double class on Feb 6)*
Fri	2/15	16. Acetylcholine (Ch 11)	Jon Lindstrom
Mon	2/18	17. Serotonin I (Ch 13)	Irwin Lucki
Wed	2/20	18. Serotonin II (Ch 13)	Irwin Lucki
Fri	2/22	19. Dopamine (Ch 12)	Julie Blendy
Mon	2/25	20. Norepinephrine (Ch 12)	Steve Thomas
Wed	2/27	Exam 2: 12 – 2 PM
		C. Peptide Signaling et al.	Randy Pittman
Fri	2/29	21. Histamine & Orexins (Ch 14 & 18; Rev. by Willie)	Steve Thomas
Mon	3/3	22. Neuroendocrine responses to stress (Ch 52)	Seema Bhatnagar
Wed	3/5	23. Peripheral nervous system & Neuropeptide Y (Ch 18)	Steve Thomas
Fri	3/7	24. Corticotropin releasing factor (Rev. by Bale/Vale)	Tracy Bale
Mon	3/10	Spring Break
Wed	3/12	Spring Break
Fri	3/14	Spring Break
Mon	3/17	25. Opiates (Revs. by Evans; Robinson/Kolb)	Wade Berrettini
Wed	3/19	26. Neural development (Ch 25; Revs. by Miyazono; Ho/Scott)	Bryan Crenshaw
Fri	3/21	27. Neuronal cell death (Revs. by Benn/Woolf; Bao/Shi)	Randy Pittman
Mon	3/24	28. Signaling by proteases (Rev.?)	Bob Siman
Wed	3/26	29. Growth factors (Ch 27)	Bob Kalb
Fri	3/28	Exam 3: 12 – 2
		D. Techniques in Neuropharmacology	*Teresa Reyes*
Mon	3/31	30. Neurochemistry	Mike Robinson
Wed	4/2	31. Immunohistochemistry	Teresa Reyes
Fri	4/4	32. Electrophysiology	Sheryl Beck
Mon	4/7	33. Neuroimaging	Tim Roberts
Wed	4/9	34. Genetics I	Julie Blendy
Fri	4/11	35. Genetics II	Ben Giasson
Mon	4/14	36. Molecular Biology	Klaus Kaestner
Wed	4/16	37. Behavior I	Irwin Lucki
Fri	4/18	38. Behavior II	Maja Bucan
Mon	4/21	39. Quantitative Receptor Analysis	Perry Molinoff
Wed	4/23	*MINS/NGG Neuroscience Retreat*
Fri	4/25	40. Drug Discovery	Menelas Pangalos
Mon	4/28	*Exam 4: 12 – 2*

In-class Written Exams - 4

There will be one exam following each major topic section. Exams are NOT cumulative. Students will be given up to 2 hours to complete each exam. Exams will be short answer, with typically one question coming from each lecture within that course section. Grades will be based on the score from only 7 (usually out of 8 or 9) exam questions. The student is to indicate which question(s) they would like to skip by writing “Do Not Grade” next to that question. Questions will be based on the material covered in the lecture, with the text and reading handouts as reference and background.

Directory of Lecturers


Abel	Biology 204G Lynch Labs	898-5614	abele@sas.upenn.edu

Bale	Neuro/Vet School 201 E Vet School Bldg	898-1369	tbale@vet.upenn.edu

Beck	Gastroenterology/Pharmacol. 402A Abramson Res. Center	590-0651	becks@email.chop.edu

Berrettini	Psychiatry 2206 Translational Res. Labs	898-0092	wadeb@mail.med.upenn.edu

Bhatnagar	Anesthesiology 402B Abramson Res. Center	267-426-0951	bhatnagars@email.chop.edu

Blendy	Pharmacology 2211 Translational Res. Labs	898-0730	blendy@mail.med.upenn.edu

Bucan	Genetics 528 Clinical Research Bldg.	898-0020	bucan@pobox.upenn.edu

Crenshaw	Otorhinolaryngology 712 Abramson Res. Center	267-426-5240	crenshaw@email.chop.edu

Eberwine	Pharmacology 37 John Morgan	898-5437	eberwine@pharm.med.upenn.edu

Field	Pharmacology 153 John Morgan	898-1912	field@pharm.med.upenn.edu

Ferraro	Psychiatry/Pharmacology 2209 Translational Res. Labs	898-0092	tnf@mail.med.upenn.edu

Giasson	Pharmacology 89A John Morgan	573-6012	giassonb@mail.med.upenn.edu

Horrigan	Physiology A401 Richards	898-2634	horrigan@mail.med.upenn.edu

Kaestner	Genetics 560A Clinical Research Bldg	898-8759	kaestner@mail.med.upenn.edu

Kalb	Neurology 814 Abramson Res. Center	590-0691	kalb@email.chop.edu

Lemmon	Biochemistry/Biophysics 809 Stellar Chance	898-3072	mlemmon@mail.med.upenn.edu

Lindstrom	Neuroscience/Pharmacology 217 Stemmler	573-2859	jslkk@mail.med.upenn.edu

Lucki	Psychiatry/Pharmacology 2204 Translational Res. Labs	573-3305	lucki@pharm.med.upenn.edu

Lynch	Neurology/Pharmacology 502 Abramson Res. Center	590-2242	lynch@pharm.med.upenn.edu

Molinoff	Pharmacology 204 Anatomy Chemistry Bldg.	898-2832	molinoff@pobox.upenn.edu

Pangalos	Wyeth Research Princeton, NJ	732-274-4125	pangalm@wyeth.com

Parsons	Veterinary Sciences New Bolton Center	610-444-5800x2554	thd@vet.upenn.edu

Pittman	Pharmacology 154 John Morgan	898-9736	pittman@pharm.med.upenn.edu

Reyes	Pharmacology 805 Biomedical Res. Bldg	573-2991	reyestm@mail.med.upenn.edu

Roberts	Radiology 2115 Wood Bldg	267-426-0384	robertstim@email.chop.edu

Robinson	Pediatrics/Pharmacology 502 Abramson	590-2205	robinson@pharm.med.upenn.edu

Siman	Pharmacology 105 Hayden Hall	898-8588	siman@pharm.med.upenn.edu

Thomas	Pharmacology 103 John Morgan	573-4950	thomas@pharm.med.upenn.edu

PHRM 510/INSC 596 Neuropharm/Neurochem

Steven Thomas

Ben Giasson

Exam 2: 12 – 2 PM

23. Peripheral nervous system & Neuropeptide Y (Ch 18)

24. Corticotropin releasing factor (Rev. by Bale/Vale)

Spring Break

Spring Break

Spring Break

28. Signaling by proteases (Rev.?)