PHRM 590 Molecular Toxicology
PHRM 590: Molecular Toxicology: Chemical and Biological Mechanisms
Mondays and Thursdays: M, Th : 1:00 – 2:00 P.M.
M100 John Morgan Bldg.
Week |
Date |
Topic |
Lecturer |
General Principles |
|||
F, Sept. 7 1:00 – 2:00 |
Introduction /Orientation |
Penning |
|
1 |
M, Sept. 10 |
General Principles: Dose Response & Exposures |
Penning |
Th, Sept. 13 |
General Principles: Toxicology Testing & Data-Bases |
Emmett |
|
2 |
M, Sept. 17 |
Metabolism-Phase I |
Penning |
Th: Sept 20 |
Metabolism-Phase II |
Penning |
|
3 |
M, Sept. 24 |
Chemical Carcinogenesis by DNA Reactive Agents |
Penning |
Th, Sept. 27 |
Reactive Oxygen Species- Chemistry and Metabolism |
Ischiropoulos |
|
4 |
M, Oct. 1 |
Heavy Metal Toxicity |
Byrns |
Th, Oct. 4 |
Chemical Carcinogenesis by Non-Genotoxic Agents |
Penning |
|
5 |
M, Oct. 8 |
DNA Adducts and their Repair |
Penning |
Organ-Based Toxicology |
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Th, Oct. 11 |
Mechanisms of Neurotoxicity-Oxidative |
Ischiropoulos |
|
6 |
M, Oct. 15 |
Toxic Responses of the Nervous System-I |
Giasson |
Th, Oct.18 |
Toxic Responses of the Nervous System-II |
Giasson |
|
7 |
M, Oct. 22 |
Mid-Term Examination |
|
Th, Oct. 25 |
Risk Assessment Assignments Mechanisms of Lung Injury- Respiratory Tract Physiology |
Haczku |
|
8 |
M, Oct. 29 |
Mechanisms of Lung Injury- Inhalation Toxicology |
Haczku |
Th, Nov. 1 |
Pharmacology Graduate Group Retreat |
||
9 |
Mon, Nov. 5 |
Mechanism of Lung Injury-Respiratory Tract Responses |
Christofidou-Solomidou |
Th, Nov. 8 |
Mechanisms of Reproductive Disruption-Male |
Manson |
|
10 |
M, Nov. 12 |
Mechanisms of Reproductive Disruption-Female |
Parry |
Th, Nov. 15 |
Mechanisms of Cardiovascular Injury |
Muzykantov |
|
11 |
M, Nov. 19 |
CEET Symposium: Genes and Environmental Health |
|
Thanksgiving Break |
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12 |
M, Nov. 26 |
Mechanisms of Cardiovascular Injury |
Muzykantov |
Predictive Molecular Toxicology |
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Th, Nov. 29 |
Toxicogenomics-Analysis of DNA Sequence Variants |
Burczynski |
|
13 |
M, Dec. 3 |
Toxicogenomics-Global Gene Expression Analysis |
Burczynski |
Th, Dec. 6 |
Bioinformatics-Integration of Data Sets |
Brunk |
|
14 |
M, Dec. 10 |
Toxicoproteomics-Analysis of sub-proteome |
Blair |
Th, Dec. 13 |
Biomarkers-Development and Validation |
Blair |
|
15 |
M, Dec. 17 |
Final Examination |
|
W, Dec. 19 1:00 – 4:00 |
Risk Assessment Papers Due (Reviewers: Ted Emmett, Linda McCauley, Richard Pepino) |
Evaluation:
Mid-Term: 30%
Final Exam: 40%
Risk Assessment Paper: 30%
Text: Cassarett & Doull’s: Toxiocology: The Basic Science of Poisons
Lecturers: |
Email Address |
Ian Blair |
ian@gcrc.upenn.edu |
Brian Brunk |
brunkb@pcbi.upenn.edu |
Ted Burczynski |
MBurczynski@wyeth.com |
Michael Byrns |
mbyrns@mail.med.upenn.edu |
Ted Emmett |
emmetted@mail.med.upenn.edu |
Benoit Giasson |
giassonb@mail.med.upenn.edu |
Angela Haczku |
haczku@mail.med.upenn.edu |
Harry Ischiropoulos |
ischirop@mail.med.upenn.edu |
Jeanne Manson |
MANSONJ@email.chop.edu |
Vladimir Muzykantov |
muzykant@mail.med.upenn.edu |
Trevor Penning |
penning@pharm.med.upenn.edu |
Melpo Christofidou-Solomidou |
melpo@mail.med.upenn.edu |
Steve Whitehead |
aswhitehead@pharm.med.upenn.edu |